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| 1 | Telomerase activity in colorectal cancer,prognostic factor and implications in the microsatellite instability pathway显示文摘AIM: To determine whether the telomerase activity is related to the Microsatellite instability (MSI) genetic pathway and whether it means a difference in the survival. METHODS: The population consisted of 97 colorectal cancer patients. MSI determination was performed in accordance with the NCI criteria using PCR and Genescan. Telomerase activity was determined by the TRAP-assay, an ELISA procedure based on the amplification of telomeric repeat sequences. RESULTS: 6.2% showed high MSI (MSI-H), 10.3% showed low MSI (MSI-L) and 83.5% did not show this alteration (MSS). Positive telomerase activity was detected in 92.8% of the patients. 83.3% of MSI-H tumors showed positive telomerase against 93.8% of MSS tumors. In the overall survival analysis the absence of telomerase activity conferred a better prognosis. CONCLUSION: Previous works have shown that tumors which develop via the MSI pathway present a better prognosis. No link between telomerase activity and MSI status is observed, although sample sizes are small. Patients with telomerase negative tumors had better overall survival than patients with telomerase positive tumors. | M Vidaurreta ML Maestro S Rafael S Veganzones MT Sanz-Casla J Cerdán M Arroyo | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 2 | Inactivation of p16 by CpG hypermethylation in renal cell carcinoma显示文摘 | Vidaurreta M Maestro ML Sanz-Casla MT | 2008 | Urol Oncol2008，26，： | 1 |
| 3 | Inactivation of p16 by CpG hypermethylation in renal cell carcinoma 显示文摘 | Vidaurreta M Maestro ML Sanz-casla MT | 2008 | Urol Oncol2008，26，3： | 1 |
| 4 | Circulating tumor cells in colorectal cancer:correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 5 | Circulating tumor cells in metastatic breast cancer: timing of blood extraction for analysis显示文摘 | Martin M Garcfa-Saenz JA Maestro De las Casas ML | 2009 | Anticancer Res2009，29，： | 1 |
| 6 | lnac~ivation of p]6 by CpG hypermethylation in renal cell carcinoma显示文摘 | Vfdaurreta M Maestro ML $anz-Casla MT | 2008 | Urol 0nco2008，26，5： | 1 |
| 7 | Prediction of survival and recurrence by serum and cytosolic levels of CEA,CA125and SCC antigens in resectable non-small-cell lung cancer显示文摘 | Diez M Torres A Maestro ML | 1996 | Br J Cancer1996，73，10： | 1 |
| 8 | Loss of heterozygosity and methylation of p]6 in renai cell carcinoma显示文摘 | Sanz-Casla MT Maestro ML Barco V et aI | 2005 | Urol Ees2005，31，3： | 1 |
| 9 | Prediction of survival and recurrence by serum and Cytosolic levels of CEA,CA125 and SCC antigens in resectable non-smallcell lung cancer显示文摘 | Diez M Torres A Maestro ML | 1996 | Br J Cancer1996，73，10： | 1 |
| 10 | Circulating tumor cells in colorectal cancer:correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | | 0，，05： | 1 |
| 11 | Quantitative analysis of cytoso- lic content Of CEA,CA125 and SCC in NonSmall Cell lung Cancer 显示文摘 | Picardo A TorresA Maestro ML | 1999 | Cancer1999，73，： | 1 |
| 12 | Circulating tumor cells in colorectal cancer:correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 13 | Prediction of survival and recurrence by serum and cytosolic levels of CEA, CA125 and SCC antigens in respectable non-cell lung cancer显示文摘 | Dies M Torres A Maestro ML | 1996 | Br J Cancer1996，10，8： | 1 |
| 14 | Circulating tumor cells in colorectal cancer:correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 15 | Circulating tumor cells in coloreetal cancer: Correlation with clinical and pathological varia- bles 显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 16 | Circulating tumor cells incolorectal cancer : correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 17 | Prediction of survival and recurrence by serum and cytosolic levels of CEA,CA125 and SCC antigens in resectable non-small-cell lung cancer显示文摘 | Diez M Torres A Maestro ML | 1996 | Br J Cancer1996，73，10： | 1 |
| 18 | Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，： | 1 |
| 19 | Loss of heterozygosity and methylation of p16 in renal cell carcinoma显示文摘 | Sanz-Casla MT Maestro ML del BV | | 0，，： | 1 |
| 20 | Quantitativeanalysis of carcinoembryonic antigen,squamous cellcarcinoma antigen,CA125 and CA50 cytosolic content innon-small cell lung cancer显示文摘 | Picardo AL Torres AJ Maestro ML | 1994 | Cancer1994，73，9： | 1 |
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