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| 1 | Using old liver grafts for liver transplantation: Where are the limits?显示文摘The scarcity of ideal liver grafts for orthotopic liver transplantation(OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. | Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González | 2014 | World Journal of Gastroenterology2014，20，31： | 11 |
| 2 | Telomerase activity in colorectal cancer,prognostic factor and implications in the microsatellite instability pathway显示文摘AIM: To determine whether the telomerase activity is related to the Microsatellite instability (MSI) genetic pathway and whether it means a difference in the survival. METHODS: The population consisted of 97 colorectal cancer patients. MSI determination was performed in accordance with the NCI criteria using PCR and Genescan. Telomerase activity was determined by the TRAP-assay, an ELISA procedure based on the amplification of telomeric repeat sequences. RESULTS: 6.2% showed high MSI (MSI-H), 10.3% showed low MSI (MSI-L) and 83.5% did not show this alteration (MSS). Positive telomerase activity was detected in 92.8% of the patients. 83.3% of MSI-H tumors showed positive telomerase against 93.8% of MSS tumors. In the overall survival analysis the absence of telomerase activity conferred a better prognosis. CONCLUSION: Previous works have shown that tumors which develop via the MSI pathway present a better prognosis. No link between telomerase activity and MSI status is observed, although sample sizes are small. Patients with telomerase negative tumors had better overall survival than patients with telomerase positive tumors. | M Vidaurreta ML Maestro S Rafael S Veganzones MT Sanz-Casla J Cerdán M Arroyo | 2007 | World Journal of Gastroenterology2007，13，28： | 8 |
| 3 | Interaction of surfactants with thickeners used in waterborne paints: A rheological study显示文摘 | Maestro A Gonzalez C Gutierrez J M | 2005 | J Colloid Interf Sci2005，288，： | 1 |
| 4 | Inactivation of p16 by CpG hypermethylation in renal cell carcinoma显示文摘 | Vidaurreta M Maestro ML Sanz-Casla MT | 2008 | Urol Oncol2008，26，： | 1 |
| 5 | Aldosterone impairs insulin responsiveness in U-937 hunmn promonocytic cells via the downregulation of its own receptor显示文摘 | Campion J Maestro B Molero S | 2002 | Cell Biochem Funct2002，20，3： | 1 |
| 6 | Hnf6 and Tcf (MODYS) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas 显示文摘 | Maestro MA Boj SF Luco RF | 2003 | Hum Mol Genet2003，12，24： | 1 |
| 7 | Spheroid preparation from hanging drops: characterization of a model of brain tumor invasion显示文摘 | Del Duca D Werbowetski T Del Maestro RF | 2004 | J Neurooncol2004，67，： | 1 |
| 8 | Twist is a potential oncogene that inhibits apoptosis 显示文摘 | Maestro R Dei A P Hamamori Y | 1999 | Genes Dev1999，13，17： | 1 |
| 9 | MDM2 overexpression does not account for stabilization of wild-type P53 protein in non-Hodgkin's lymphoma显示文摘 | Maestro R Gloghini A Doglioni C | 1995 | Blood1995，85，11： | 1 |
| 10 | Inactivation of p16 by CpG hypermethylation in renal cell carcinoma 显示文摘 | Vidaurreta M Maestro ML Sanz-casla MT | 2008 | Urol Oncol2008，26，3： | 1 |
| 11 | Ezrin regulatesE-chadherin-dependent adherens junction assembly through Raclactivation显示文摘 | Pujuguet P Del Maestro L Gautreau A | 2003 | Mol Biol Cell2003，14，5： | 1 |
| 12 | Circulating tumor cells in colorectal cancer:correlation with clinical and pathological variables显示文摘 | Sastre J Maestro ML Puente J | 2008 | Ann Oncol2008，19，5： | 1 |
| 13 | Non - structural carbohydrates and nitrogen dynamics in mediterranean sub - shrubs: an analysis of the functional role of overwintering leaves 显示文摘 | Palacio S Millard P Maestro M | 2007 | Plant Biology2007，9，1： | 1 |
| 14 | Circulating tumor cells in metastatic breast cancer: timing of blood extraction for analysis显示文摘 | Martin M Garcfa-Saenz JA Maestro De las Casas ML | 2009 | Anticancer Res2009，29，： | 1 |
| 15 | lnac~ivation of p]6 by CpG hypermethylation in renal cell carcinoma显示文摘 | Vfdaurreta M Maestro ML $anz-Casla MT | 2008 | Urol 0nco2008，26，5： | 1 |
| 16 | Prediction of survival and recurrence by serum and cytosolic levels of CEA,CA125and SCC antigens in resectable non-small-cell lung cancer显示文摘 | Diez M Torres A Maestro ML | 1996 | Br J Cancer1996，73，10： | 1 |
| 17 | Aldosterone impairs insulin responsiveness in U-937 human promonocytic cells via the downregulation of its own receptor显示文摘 | Campion J Maestro B Molero S | 2002 | Cell Biochem Funct2002，20，3： | 1 |
| 18 | Aldosterone impars insulin responsiveness in U-937 human promonocytie cells via the downregulation of its own receptor显示文摘 | Campion J Maestro B Molero S | 2002 | Cell Biochem Funct2002，20，3： | 1 |
| 19 | TWIST1 plays a pleiotropic role in determining the anaplastic thyroid cancer phenotype 显示文摘 | Maestro R Salerno P Garcia-Rostan G | 2011 | J Clin Endocrinol Metab2011，96，5： | 1 |
| 20 | Loss of heterozygosity and methylation of p]6 in renai cell carcinoma显示文摘 | Sanz-Casla MT Maestro ML Barco V et aI | 2005 | Urol Ees2005，31，3： | 1 |
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