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6篇 您的检索式:作者名="Madeha"
    题名 作者 年代 出处 被引量
1The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage显示文摘Ahmed O. Abdel-Zaher Randa H. Abdel-Hady Madeha M. Mahmoud Magda M.Y. Farrag 2007Toxicology2007,,3:2
2Circulating leptin and insulin in obese patients with and without type 2 diabetes mellitus: Relation to ghrelin and oxidative stress 显示文摘ENAS A HAMED MADEHA M ZAKARY NAGWA S AHMED 2011Diabetes ''Res Clinical Practice2011,94,3:1
3Oxidative Stress in the Context of Acute Cerebrovascular Stroke显示文摘Mohsen Muhammad Hussein El Kossi Madeha Mahrous Zakhary 2000Stroke: Journal of the American Heart Association2000,,8:1
4Oxidative Stress in the Context of Acute Cerebrovascular Stroke显示文摘Mohsen Muhammad Hussein El Kossi Madeha Mahrous Zakhary 2000Stroke: Journal of the American Heart Association2000,,8:1
5The potential protec- tive role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage 显示文摘Ahmed O Randa H Madeha M 2008Toxicology2008,,243:1
6Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor regulate the interaction between astrocytes and Schwann cells at the trigeminal root entry zone显示文摘The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central oligodendrocytes.Its special anatomical and physiological structure renders it susceptible to nerve injury.The etiology of most primary trigeminal neuralgia is closely related to microvascular compression of the trigeminal root entry zone.This study aimed to develop an efficient in vitro model mimicking the glial environment of trigeminal root entry zone as a tool to investigate the effects of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor on the structural and functional integrity of trigeminal root entry zone and modulation of cellular interactions.Primary astrocytes and Schwann cells isolated from trigeminal root entry zone of postnatal rats were inoculated into a two-well silicon culture insert to mimic the trigeminal root entry zone microenvironment and treated with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor.In monoculture,glial cell line-derived neurotrophic factor promoted the migration of Schwann cells,but it did not have effects on the migration of astrocytes.In the co-culture system,glial cell line-derived neurotrophic factor promoted the bidirectional migration of astrocytes and Schwann cells.Brain-derived neurotrophic factor markedly promoted the activation and migration of astrocytes.However,in the co-culture system,brain-derived neurotrophic factor inhibited the migration of astrocytes and Schwann cells to a certain degree.These findings suggest that glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor are involved in the regulation of the astrocyte-Schwann cell interaction in the co-culture system derived from the trigeminal root entry zone.This system can be used as a cell model to study the mechanism of glial dysregulation associated with trigeminal nerve injury and possible therapeutic interventions.Madeha Ishag Adam Ling Lin Amir Mahmoud Makin Xiao-Fen Zhang Lu-Xi Zhou Xin-Yue Liao Li Zhao Feng Wang Dao-Shu Luo 2023Neural Regeneration Research2023,18,6:0
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