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| 1 | Post-transplantation lymphoproliferative disorders:Current concepts and future therapeutic approaches显示文摘Transplant recipients are vulnerable to a higher risk of malignancy after solid organ transplantation and allogeneic hematopoietic stem-cell transplant.Posttransplant lymphoproliferative disorders(PTLD)include a wide spectrum of diseases ranging from benign proliferation of lymphoid tissues to frank malignancy with aggressive behavior.Two main risk factors of PTLD are:Firstly,the cumulative immunosuppressive burden,and secondly,the oncogenic impact of the Epstein-Barr virus.The latter is a key pathognomonic driver of PTLD evolution.Over the last two decades,a considerable progress has been made in diagnosis and therapy of PTLD.The treatment of PTLD includes reduction of immunosuppression,rituximab therapy,either isolated or in combination with other chemotherapeutic agents,adoptive therapy,surgical intervention,antiviral therapy and radiotherapy.In this review we shall discuss the prevalence,clinical clues,prophylactic measures as well as the current and future therapeutic strategies of this devastating disorder. | Fedaey Abbas Mohsen El Kossi Ihab Sakr Shaheen Ajay Sharma Ahmed Halawa | 2020 | World Journal of Transplantation2020，10，2： | 6 |
| 2 | Human leukocyte antigen typing and crossmatch:A comprehensive review显示文摘Renal transplantation remains the best option for patients suffering from end stage renal disease(ESRD).Given the worldwide shortage of organs and growing population of patients with ESRD,those waitlisted for a transplant is ever expanding.Contemporary crossmatch methods and human leukocyte antigen(HLA) typing play a pivotal role in improving organ allocation and afford better matches to recipients.Understanding crossmatch as well as HLA typing for renal transplantation and applying it in clinical practice is the key step to achieve a successful outcome.Interpretation of crossmatch results can be quite challenging where clinicians have not had formal training in applied transplant immunology.This review aims to provide a worked example using a clinical vignette.Furthermore,each technique is discussed in detail with its pros and cons.The index case is that of a young male with ESRD secondary to Lupus nephritis.He is offered a deceased donor kidney with a 1-0-0 mismatch.His complement dependent cytotoxicity(CDC) crossmatch reported positive for B lymphocyte,but flow cytometry crossmatch(FCXM) was reported negative for both B and T lymphocytes.Luminex-SAB(single antigen bead) did not identify any donor specific antibodies(DSA).He never had a blood transfusion.The positive CDCcrossmatch result is not concordant with DSA status.These implausible results are due to underlying lupus erythematosus,leading to false-positive B-lymphocyte crossmatch as a result of binding immune complexes to Fc-receptors.False positive report of CDC crossmatch can be caused by the underlying autoimmune diseases such as lupus erythematosus,that may lead to inadvertent refusal of adequate kidney grafts.Detailed study of DSA by molecular technique would prevent wrong exclusion of such donors.Based on these investigations this patient is deemed to have 'standard immunological risk' for renal transplantation. | Mohammed Mahdi Althaf Mohsen El Kossi Jon Kim Jin Ajay Sharma Ahmed Mostafa Halawa | 2017 | World Journal of Transplantation2017，7，6： | 5 |
| 3 | De novo glomerular diseases after renal transplantation:How is it different from recurrent glomerular diseases?显示文摘The glomerular diseases after renal transplantation can occur de novo,i.e.,with no relation to the native kidney disease,or more frequently occur as a recurrence of the original disease in the native kidney.There may not be any difference in clinical features and histological pattern between de novo glomerular disease and recurrence of original glomerular disease.However,structural alterations in transplanted kidney add to dilemma in diagnosis.These changes in architecture of histopathology can happen due to:(1) exposure to the immunosuppression specifically the calcineurin inhibitors(CNI);(2) in vascular and tubulointerstitial alterations as a result of antibody mediated or cellmediated immunological onslaught;(3) post-transplant viral infections;(4) ischemia-reperfusion injury; and(5) hyperfiltration injury.The pathogenesis of the de novo glomerular diseases differs with each type.Stimulation of B-cell clones with subsequent production of the monoclonal Ig G,particularly Ig G3 subtype that has higher affinity to the negatively charged glomerular tissue,is suggested to be included in PGNMID pathogenesis.De novo membranous nephropathy canbe seen after exposure to the cryptogenic podocyte antigens.The role of the toxic effects of CNI including tissue fibrosis and the hemodynamic alterations may be involved in the de novo FSGS pathophysiology.The well-known deleterious effects of HCV infection and its relation to MPGN disease are frequently reported.The new concepts have emerged that demonstrate the role of dysregulation of alternative complement pathway in evolution of MPGN that led to classifying into two subgroups,immune complex mediated MPGN and complement-mediated MPGN.The latter comprises of the dense deposit disease and the C3 GN disease.De novo C3 disease is rather rare.Prognosis of de novo diseases varies with each type and their management continues to be empirical to a large extent. | Fedaey Abbas Mohsen El Kossi Jon Kim Jin Ajay Sharma Ahmed Halawa | 2017 | World Journal of Transplantation2017，7，6： | 4 |
| 4 | Thrombotic microangiopathy after renal transplantation: Current insights in de novo and recurrent disease显示文摘Thrombotic microangiopathy(TMA) is one of the most devastating sequalae of kidney transplantation. A number of published articles have covered either de novo or recurrent TMA in an isolated manner. We have, hereby, in this article endeavored to address both types of TMA in a comparative mode. We appreciate that de novo TMA is more common and its prognosis is poorer than recurrent TMA; the latter has a genetic background, with mutations that impact disease behavior and, consequently, allograft and patient survival. Post-transplant TMA can occur as a recurrence of the disease involving the native kidney or as de novo disease with no evidence of previous involvement before transplant. While atypical hemolytic uremic syndrome is a rare disease that results from complement dysregulation with alternative pathway overactivity, de novo TMA is a heterogenous set of various etiologies and constitutes the vast majority of post-transplant TMA cases. Management of both diseases varies from simple maneuvers, e.g., plasmapheresis, drug withdrawal or dose modification, to lifelong complement blockade, which is rather costly. Careful donor selection and proper recipient preparation, including complete genetic screening, would be a pragmatic approach. Novel therapies, e.g., purified products of the deficient genes, though promising in theory, are not yet of proven value. | Fedaey Abbas Mohsen El Kossi Jon Jin Kim Ajay Sharma Ahmed Halawa | 2018 | World Journal of Transplantation2018，8，5： | 4 |
| 5 | Recurrence of primary glomerulonephritis:Review of the current evidence显示文摘In view of the availability of new immunosuppression strategies,the recurrence of allograft glomerulonephritis(GN) are reported to be increasing with time post transplantation.Recent advances in understanding the pathogenesis of the GN recurrent disease provided a better chance to develop new strategies to deal with the GN recurrence.Recurrent GN diseases manifest with a variable course,stubborn behavior,and poor response to therapy.Some types of GN lead to rapid decline of kidney function resulting in a frustrating return to maintenance dialysis.This subgroup of aggressive diseases actually requires intensive efforts to ascertain their pathogenesis so that strategy could be implemented for better allograft survival.Epidemiology of native glomerulonephritis as the cause of end-stage renal failure and subsequent recurrence of individual glomerulonephritis after renal transplantation was evaluated using data from various registries,and pathogenesis of individual glomerulonephritis is discussed.The following review is aimed to define current protocols of the recurrent primary glomerulonephritis therapy. | Fedaey Abbas Mohsen El Kossi Jon Kim Jin Ajay Sharma Ahmed Halawa | 2017 | World Journal of Transplantation2017，7，6： | 2 |
| 6 | The management of CKD: A look into the future 显示文摘 | Khwaja A E1 Kossi M Floege J E1 Nahas M | 2007 | Kidney Int2007，72，11： | 1 |
| 7 | The impact of stop- ping inhibitors of the renin-angiotensin system in patients with ad- vanced chronic kidney disease 显示文摘 | Ahmed AK Kamath NS EI Kossi M | 2010 | Nephrol Dial Transplant2010，25，12： | 1 |
| 8 | Surgical workload and cost of postoperative adhesion-related intestinal obstruction: importance of previous surgery 显示文摘 | Kossi JA Salminen PT Laato MK | 2004 | World J Surg2004，28，7： | 1 |
| 9 | Current collapse and the role of carbon in A1GaN/GaN high electron mobility transistors grown by metalorganic vapor-phase epitaxy显示文摘 | Klein P B Binari S C Kossi K | 2001 | Appl Phys Lett2001，79，21： | 1 |
| 10 | Oxidative stress in the contexff acute cerebrova scular strole显示文摘 | El Kossi MM Zakhary MM | 2000 | Stroke2000，31，8： | 1 |
| 11 | Initial experience of the feasibility of single-incision laparoscopic appendectomy in different clinical conditions显示文摘 | Kossi J Luostarinen M | | 0，，： | 1 |
| 12 | Stem cell factor in a rat model of serum nephrotoxic nephritis显示文摘 | EI Kossi MM Haylor JL Johnson TS | 2008 | Nephron Exp Neph- rol2008，108，1： | 1 |
| 13 | Surgical workload and cost of postoperative adhesion related intestinal obstruction: importance of previous surgery 显示文摘 | Jyrki AO Kossi MD Paulina TP | 2004 | World J Surg2004，28，7： | 1 |
| 14 | Oxidative stress in the context of acute cerebrovascular stroke显示文摘 | EI Kossi MM Zakhay MM | 2000 | Stroke2000，31，8： | 1 |
| 15 | 技术创新环境建设中的政府、企业、高校作用探讨——以广州为例显示文摘技术创新环境是由大学、科研机构、企业、地方政府等行为主体相互作用所形成的一个相对稳定的社会网络系统。本文以广州为例,探讨了技术创新环境建设中政府、高校(科研机构)、企业等不同主体的作用及其相互关系的问题。结论认为,技术创新环境建设是一个复杂的系统工程,技术创新的目标能否实现并推动地区经济发展,取决于各个创新主体能否有效发挥作用,以及它们之间所能达到的协调发展、相互合作的程度。 | 达尼KPOKPOYA KOSSI DIEU-DONNE 朱一中 | 2009 | 科技资讯2009，7，10： | 1 |
| 16 | Oxidative Stress in the Context of acute Cerebrovascular Styoke显示文摘 | EI Kossi MM Zakhary MM | | 0，，05： | 1 |
| 17 | Oxidative slress in the context of acute ee- rebrovascular stroke显示文摘 | El Kossi MM Zakhary MM | 2000 | Stroke2000，31，8： | 1 |
| 18 | Oxidative stress in the context of acute cerebrovaseular stroke 显示文摘 | Kossi MM Zakhary MM | 2000 | Stroke2000，31，8： | 1 |
| 19 | Surgical workload and cost of postoperative adhesion related intestinal obstruction:importance of previous surgery显示文摘 | Jyrki AO Kossi MD Paulina TP | 2004 | World J Surg2004，28，： | 1 |
| 20 | Oxidative stress in the context of a-cute cerebrovascular stroke 显示文摘 | Kossi MM Zakhary MM | 2000 | Stroke2000，31，8： | 1 |
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