|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 3 | Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer显示文摘AIM:To study the effect of celecoxib(CXB) on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis model.METHODS:Six-week-old male Sprague-Dawley rats were randomly divided into fi ve groups,a non-treated group(NT) ,a diethylnitrosamine-treated group(DEN) ,a DEN+CXB-treated group(DEN+CXB) ,and CXB 8 d-treated and CXB 32 d-treated groups.The effects of celecoxib on the enzymatic activities of CYP1A1,2A,2B1/2,and 2E1 were assessed in hepatic microsomes 24 h after DEN administration.Changes in CYP1A1 and CYP2B1/2 protein expression were also evaluated.The rate of DEN metabolism was measured by the production of the deethylation metabolite acetaldehyde,and the denitrosation metabolite nitrite.RESULTS:DEN+CXB administration produced a significant increase in the enzymatic activities of CYP2B1/2 and 1A1,whereas it did not change the activities of CYP2A and 2E1,compared to that of the DEN group.CXB treatment for eight days did not produce a signif icant effect on enzymatic activity when compared to the NT group;however,when it was administered for prolonged times(CXB 32 d group) ,the enzymatic activities were increased in a similar pattern to those in the DEN+CXB group.The observed increase in the enzymatic activities in the DEN+CXB group was accompanied by an increase in the CYP2B1/2 protein levels;no changes were observed in the levels of CYP1A1.In vitro,CXB increased the denitrosation of DEN,a pathway of metabolic detoxification.The addition of SKF-525A,a preferential inhibitor of CYP2B,abrogated the denitrosation of DEN.CONCLUSION:These results suggest that the mechanism of action of CXB involves enhancement of the detoxif ication of DEN by an increasing denitrosation via CYP2B1/2. | Martha Estela Salcido-Neyoy Adolfo Sierra-Santoyo Olga Beltrán-Ramírez José Roberto Macías-Pérez Saúl Villa-Trevio | 2009 | World Journal of Gastroenterology2009，15，19： | 3 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans显示文摘 | Calbet J A L Mac Lean D A | 2002 | J Nutr2002，132，： | 1 |
| 6 | De- termination of undegradable intake protein digestibility of forages using the mobile nylon bag technique 显示文摘 | HAUGEN H L IVAN S K MAC DONALD J C | 2006 | J Anita Sci2006，84，： | 1 |
| 7 | Anaerobic digestion of organicsolid wastes:Anoverview of research achievements and perspectives显示文摘 | Alvarez J M Macés L P | | 0，，74： | 1 |
| 8 | Molecular analysis of 30 Niemann-Pick type C patients from Spain显示文摘 | Macías-Vidal J Rodríguez-Pascau L Sánchez-Ollé G | 2011 | Clin Genet2011，80，1： | 1 |
| 9 | Global transcriptome profiles of Camellia sinensis during cold acclimation 显示文摘 | WANG X C ZHAO Q Y MAC L | 2013 | BMC Genomics2013，14，： | 1 |
| 10 | Formation and degradation of dichloroacetonitrile in drinking waters显示文摘 | Reckhow D A Mac Neill A L Platt T L | 2001 | Journal of Water Supply:Research and Technology Aqua2001，50，1： | 1 |
| 11 | Planar antennas in LTCC technology with transceiver integration capability for ultra-wideband applications 显示文摘 | Brzezina G Roy L Mac Eachern L | 2006 | IEEE Transaction on microwave theory and techniques2006，54，6： | 1 |
| 12 | Interferon-regulated viral replication in chronically HIV-1 infected promonocytic U937 cells 显示文摘 | Macé K Gazzolo L | 1991 | Res Virol1991，142，23： | 1 |
| 13 | Evaluation of Brnsted sites inside the H-MOR employing NH3: A theoretical study显示文摘 | DíAZ L SIERRAALTA A NASCIMENTO MAC A | 2013 | J Phys Chem C2013，117，10： | 1 |
| 14 | Carbamazepine oxidation catalyzed by manganese porphyrins:Effects of theβ-bromination of the macrocycle and the choice of oxidant显示文摘 | Carvalhoda S D Mac L T Cristina O | 2011 | Applied Catalysis A:General2011，408，12： | 1 |
| 15 | Deletion of dentin matrix protein-1 leads to a partpal failure of maturation of pre- dentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development 显示文摘 | YE L MAC DOUGALL M ZHANG S | 2004 | Biol Chem2004，279，18： | 1 |
| 16 | Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury显示文摘 | Brody D L Mac Donald C Kessens C C | 2007 | Journal of neurotrauma2007，24，4： | 1 |
| 17 | Factors associated with surgical decision making in women with early - stage breast cancer : a literature review 显示文摘 | Mac Bride MB Neat L Dilavefi CA et at | 2013 | J Womens Health (Larchmt)2013，22，3： | 1 |
| 18 | Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury显示文摘 | Mac Donald C L Dikranian K Bayly P | 2007 | J Neurosci2007，27，11： | 1 |
| 19 | Risk of Liver Decompensation Among HIV/Hepatitis C Virus–Coinfected Individuals With Advanced Fibrosis: Implications for the Timing of Therapy显示文摘 | Juan Macías Manuel Márquez Francisco Téllez Dolores Merino Patricia Jiménez-Aguilar Luis F. López-Cortés Enrique Ortega Miguel A. von Wichmann Antonio Rivero María Mancebo Jesús Santos Montserrat Pérez-Pérez Ignacio Suárez-Lozano Alberto Romero-Palacios A | 2013 | Clinical Infectious Diseases2013，，10： | 1 |
| 20 | Endothelial adhesion molecules ICAM-1,VCAM-1 and E-selectin in Patients with Acute Coronary Syndrome 显示文摘 | Macías C Villaescusa R Valle L et al | 2003 | Rev Esp Cardiol2003，56，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员