|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Colorectal cancer:Current imaging methods and future perspectives for the diagnosis, staging and therapeutic response evaluation显示文摘In the last 10 years the mortality rate of colorectal cancer(CRC)has decreased by more than 20%due to the rising developments in diagnostic techniques and optimization of surgical,neoadjuvant and palliative therapies.Diagnostic methods currently used in the evaluation of CRC are heterogeneous and can vary within the countries and the institutions.This article aims to discuss in depth currently applied imaging modalities such as virtual computed tomography colonoscopy,endorectal ultrasound,computed tomography(CT)and magnetic resonance imaging(MRI)in the diagnosis of CRC.Special focus is put on the potential of recent diagnostic developments as diffusion weighted imaging MRI,MRI biomarkers(dynamic enhanced MRI),positron emission tomography with 2-(fluorine-18)-fluoro-2-deoxy-D-glucose(FDG-PET)combined with computed tomography(PET/CT)and new hepatobiliary MRI contrast agents.The precise role,advantage and disadvantages of these modalities are evaluated controversially in local staging,metastatic spread and treatment monitoring of CRC.Finally,the authors will touch upon the future perspectives in functional imaging evaluating the role of integrated FDG-PET/CT with perfusion CT,MRI spectroscopy of primary CRC and hepatic transit time analysis using contrast enhanced ultrasound and MRI in the detection of liver metastases.Validation of these newer imaging techniques may lead to significant improvements in the management of patients with colorectal cancer. | Maka Kekelidze Luigia D'Errico Michele Pansini Anthony Tyndall Joachim Hohmann | 2013 | World Journal of Gastroenterology2013，19，46： | 28 |
| 2 | Transposable elements significantly contributed to the core promoters in the human genome显示文摘Transposable elements(TEs) are major components of the human genome constituting at least half of it. More than half a century ago, Barbara McClintock and later Roy Britten and Eric Davidson have postulated that they might be major players in the host gene regulation. We have scanned a large amount of data produced by ENCODE project for active transcription binding sites(TFBSs) located in TE-originated parts of polymerase II promoters. In total, more than 35,000 promoters in six different tissues were analyzed and over 26,000 of them harbored TEs. Moreover, these TEs usually provide one or more of TFBSs in the host promoters, which resulted in more than 6% of active TFBSs in these regions located in the TE-originated sequences. Rewiring of transcription circuits played a major role in mammalian evolution and consequently increased their functional and morphological diversity. In this large-scale analysis, we have demonstrated that TEs contributed a large fraction of human TFBSs. Interestingly,these TFBSs usually act in a tissue-specific manner. Thus, our study clearly showed that TEs played a significant role in shaping expression pattern in mammals and humans in particular. Furthermore, since several TE families are still active in our genome,they continue to influence not only our genome architecture but also gene functioning in a broader sense. | Marten Kellner Wojciech Maka?owski | 2019 | Science China(Life Sciences)2019，62，4： | 2 |
| 3 | Control of oxidative sulfur metabolism of Chlorobium limicols fonna thiosulfatophilum 显示文摘 | Cork D J Mather A Maka A Smak | 1985 | Applied Environmental Microbiology1985，49，： | 1 |
| 4 | Control of oxidative sulfur metabolism of Chlorobium limicola forma Thiosulfatophilum 显示文摘 | Cork D Mathers J Maka A | 1985 | Applied and Environmental Microbiology1985，49，2： | 1 |
| 5 | Emission properties of dye-polymer-opal photonic crystals显示文摘 | ROMANOV S G MAKA T TORRES C M S | 1999 | J Lightwave Technol1999，17，11： | 1 |
| 6 | Drug-nutrient interactions:a review显示文摘 | MAKA D A MURPHY L K | 2000 | AACN Advanced Critical Care2000，11，4： | 1 |
| 7 | Orbitahumour as initial manifestation of a(ute myeloid leukemia: granuloeyti(, sare na: case report显示文摘 | Maka E Luk6ts O Tbth J | 2008 | Palhol Oneol Res2008，14，： | 1 |
| 8 | Conceptual framework and belief function approach to assessing overall information quality 显示文摘 | Bovee M Srivastava R P MakA B | 2003 | Information journal of intelligent systems2003，，18： | 1 |
| 9 | Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect显示文摘 | Maka M Stolt CC Wegner M | | 0，，01： | 1 |
| 10 | Orbital tumour as initial manifestation of acute myeloid leukemia:granulocytic sarcoma:case report显示文摘 | Maka E Lukats O Toth J | 2008 | Pathol Oncol Res2008，14，2： | 1 |
| 11 | Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect显示文摘 | Maka M Stolt CC Wegner M | 2005 | Dev Biol2005，277，1： | 1 |
| 12 | Control of oxidative sulfur metabolism of Chlorobium limicola forma thiosulfatophilum显示文摘 | Cork D J Mather A Maka A Srnak | 1985 | Applied Environmental Microbioogy1985，49，： | 1 |
| 13 | Quantum efficiency requirements for an anaerobic photobioreator显示文摘 | Maka A D Cork | 1990 | Industrial Microbiology1990，5，： | 1 |
| 14 | The effect of quartz content on the mechanical activation of dolomite 显示文摘 | Eva Maka | 2007 | J Eur Ceram Soc2007，27，23： | 1 |
| 15 | Doxorubiein selectively suppresses mRNA expression and production of endothelin - 1 in endothelial ceils 显示文摘 | Katalin Keltai Laszlo Cervenak Veronika Maka | 2010 | Vas- cul Pharmacol2010，53，56： | 1 |
| 16 | Factors influencing touristfood consumption显示文摘 | MakA H N Lumbers M Eves A | 2012 | International Journal of Hospitality Manage-ment2012，31，3： | 1 |
| 17 | ACE inhibitors attenu- ate expressi on of renal transforming growth factor-betal in humans 显示文摘 | ShinGT KimSJ MaKA | 2000 | Am J Kidney Dis2000，36，5： | 1 |
| 18 | Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect 显示文摘 | Maka M Stolt CC Wegner M | 2005 | Dev Biol2005，277，1： | 1 |
| 19 | Globalisation and food consump-tion in tourism显示文摘 | MakA H N Lumbers M Eves A | 2012 | Annals of Tourism Research2012，39，1： | 1 |
| 20 | Variability on nucleation and growth of short fatigue cracks due to material anisotropy in aluminum 2024-T351 显示文摘 | Makas A Avallone J Mackinnon R | 2013 | Journal of Intelligent Material Systems and Structures2013，24，17： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员