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| 1 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 2 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 3 | Effects of plant extracts on microbial growth,color change,and lipid oxidation in cooked beef显示文摘 | Ahn J Grun I U Mustapha A | 2007 | Food Microbiology2007，24，1： | 1 |
| 4 | Satellite-measured seasonal variations in primary production in the scallop-farming region of the Okhotsk Sea 显示文摘 | MUSTAPHA M A SEI-ICH1 S LIHAN T | 2009 | ICES Journal of Marine Science2009，66，7： | 1 |
| 5 | Simultaneous detection of Escherichia coli O157:H7 and Salmonella and Shigella in apple cider and produce by a multiplex PCR显示文摘 | LI Y MUSTAPHA A | 2006 | Journal of Food Protection2006，67，1： | 1 |
| 6 | Numerical simulation of transient vaporous and gaseous cavitation in pipe- lines显示文摘 | KESSAL M MUSTAPHA A | 2001 | International Journal of Numerical Methods for Heat & Fluid Flow2001，11，2： | 1 |
| 7 | EMA-real-time PCR as a reliable method for detection of viable Salmonella in chicken and eggs显示文摘 | Wang L Mustapha A | 2010 | J Food Sei2010，75，： | 1 |
| 8 | Intrinsic resistance to apoptosis of colon epithelial cells is a potential determi- ning factor in the susceptibility of the a/j mouse strain to dimethyl- hydrazine - induced colon tumorigenesis显示文摘 | BOULARES A H KARINE O B MUSTAPHA O a al | 2007 | Mol Carcinogen2007，46，12： | 1 |
| 9 | A direct requirement of nuclear factor-kappa B for suppression of apotosis in ventricular myocytes显示文摘 | Kirhner A De Moissac D | 2000 | Am J Physiol Heart Circ Physiol2000，279，3： | 1 |
| 10 | A direct requirement of nuclear factor-kappa B for suppression of apoptosis in ventricular myocytes 显示文摘 | Mustapha S Kirshner A De Moissac D | 2000 | Am J Physiol Heart Cir Physiol2000，279，3： | 1 |
| 11 | A direct requirement of nuclear factor kappa B for suppression of apoptosis in vent IR myocytes显示文摘 | Mustapha S Kirshner A De Moissar D | 2000 | Am J Physiol Heart Circ Phsiol2000，279，： | 1 |
| 12 | EMA-real-time PCR as a reliable method for detection of viable Salmonella in chicken and eggs显示文摘 | Wang L Mustapha A | 2010 | J Food Sci2010，75，3： | 1 |
| 13 | Effect of Pregnancy on Some Biochemical Parameters in Sahel Goat in Semi-arid Zones显示文摘 | Sandabe U K Mustapha A R Sambo E Y | 2004 | Vet Res Comm2004，28，： | 1 |
| 14 | Classification-based data mining approach for quality control in wine production 显示文摘 | Appalasamy P Mustapha A Rizal N D | 2012 | Journal of Applied Sciences2012，12，6： | 1 |
| 15 | Antibacterial activities of zinc oxide nanoparticles against Escherichia coli O157∶H7显示文摘 | Liu Y He L Mustapha A Li H Hu ZQ Lin M | 2009 | J Appl Microbiol2009，107，4： | 1 |
| 16 | Clinical pre- sentation and management of drug-induced agranulocyto- sis显示文摘 | Emmanuel A Jacques Z Mustapha M | 2011 | Expert Rev Hematol2011，4，2： | 1 |
| 17 | Application of a multiplex PCR for the simuhaneous detection of Escherichia coli O157:H7,Salmonella and Shigella in raw and ready-to-eat meat products显示文摘 | Li Y Zhuang S Mustapha A | 2005 | Meat Science2005，71，2： | 1 |
| 18 | Improvement of lactose digestion by humans following ingestion of unfermented acidophilus milk:influence of bile sensitivity,lactose transport and acid tolerance of Lb Acidophilus显示文摘 | Mustapha A Jiang T Savaiano A | 1997 | Journal of Dairy Science1997，80，： | 1 |
| 19 | Rapid detection of food-and waterborne bacteria using surface-enhanced Raman spectroscopy coupled with silver nanosubstrates 显示文摘 | Fan C Hu Z Mustapha A | 2011 | Applied microbiology and biotechnology2011，92，5： | 1 |
| 20 | Underground flow simulations using parallel finite element method显示文摘 | MUSTAPHA H GHORAYEB A MUSTAPHA K A | | 0，，02： | 1 |
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