|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Modeling the infiltration kinetics of molten aluminum into porous titanium carbide显示文摘 | Muscat D Drew R A L | 1994 | Metall Trans A1994，25，11： | 1 |
| 3 | Hyperbranched polyesteramides-- new dendritic polymers 显示文摘 | Muscat D van Benthem R A T M | 2001 | Top Curr Chem2001，212，： | 1 |
| 4 | Molding the infiltration kinetics of molten aluminum into porous titanium carbide 显示文摘 | MUSCAT D DREW R A L | 1994 | Metall Trans1994，25，： | 1 |
| 5 | Smoking and pancreatic cancer in men and women显示文摘 | Muscat JE Stellman SD Hoffmann D | 1997 | Cancer Epidemi- ol Biomarkers Prey1997，6，1： | 1 |
| 6 | Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells 显示文摘 | Melissa J Knight Christopher D Riffkin Andrea M Muscat | 2001 | Oncogene2001，20，： | 1 |
| 7 | Repeatability and repro-ducibility of macular thickness measurements w ith the Hum-phrey OCT system显示文摘 | Muscat S Parks S Kemp E Keating D | 2002 | Invest Ophthalmol Vis Sci2002，43，2： | 1 |
| 8 | A New Route to Self-Assembled Tin Dioxide Nanospheres: Fabrication and Chacterization显示文摘 | Deng Z T Peng B Chen D Tang F Q Muscat A J | 2008 | Langmuir2008，24，11： | 1 |
| 9 | Comparative study of film forming behaviour of low and high amylase stahes using glycerol and xylitol as plasticizers 显示文摘 | Muscat D Adhikari B Adhikari R | 2012 | Journal of Food Engineering2012，109，： | 1 |
| 10 | Chemisorption on metals显示文摘 | Muscat J P Newns D M | 1978 | Prog Surf Sci1978，9，： | 1 |
| 11 | A work criterionfor plastic collapse 显示文摘 | Muscat M Mackenzie D Hamilton R | 2003 | International Journal of PressureVessels and Piping2003，80，： | 1 |
| 12 | Arterial injuries in orthopedics:the posteromedial approach for vascular control about the knee显示文摘 | MUSCAT J D ROGERS W CRUZ A B | 1996 | J Orthop Trauma1996，10，7： | 1 |
| 13 | Repeat ability and reproducibility of corneal thickness measurements by optical coherence tomography显示文摘 | Muscat S Mckay N Parks S Kemp E Keating D | 2002 | Invest Ophthalmol Vis Sci2002，43，5： | 1 |
| 14 | Imposex as a biomonitoring tool for marine pollution by tributyltin: some further observations 显示文摘 | Axiak V MicaUef D Muscat J | 2003 | Environment International2003，28，： | 1 |
| 15 | First principles studies of the surface of galena PbS 显示文摘 | MUSCAT J GALE J D | 2003 | Geochim Cosmochim Acta2003，67，： | 1 |
| 16 | Elastic - Shakedown Analysis of Axisymmetric Nozzles 显示文摘 | Muscat M Mackenzie D | 2003 | Journal of Pressure Vessel Technology2003，125，4： | 1 |
| 17 | Evaluating Shakedown under Proportional Loading by Non - linear Static Analysis 显示文摘 | Muscat M Mackenzie D Hamilton R | 2003 | Computers & Structures2003，81，17： | 1 |
| 18 | First principles studies of the surface ofgalena PbS 显示文摘 | MUSCAT J GALE J D | 2003 | Geochimica et Cosmochimica Acta2003，67，5： | 1 |
| 19 | Understanding the distribution of natural wax in starch - wax films using synchrotron - based FI'IR ( S - grIR) 显示文摘 | Muscat D Tobin M J Guo Q P | 2014 | Carbohydrate Polymers2014，102，： | 1 |
| 20 | Modeling the infiltration kinetics of molten aluminum into porous titanium carbide显示文摘 | MUSCAT D DREW R A L | 1994 | Metall Mater Trans1994，25，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员