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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Chronic mild stress-induced anhedonia:a realistic animal model of depression显示文摘 | Willner P Muscat R Papp M | | 0，，： | 1 |
| 3 | Planned preoperative radiation therapy in muscle invasive bladder cancer : results of a meta-analysis 显示文摘 | Huncharek M Muscat J Geschwind J F | 1998 | Anti-cancer Res1998，18，： | 1 |
| 4 | Impact of dairy products and dietary calcium on bone-mineral content in children: Results of a meta-analysis 显示文摘 | HUNCHAREK M MUSCAT J KUPELNICKB B | 2008 | Bone2008，43，2： | 1 |
| 5 | Hyperbranched polyesteramides-- new dendritic polymers 显示文摘 | Muscat D van Benthem R A T M | 2001 | Top Curr Chem2001，212，： | 1 |
| 6 | Multi-drug versus single agent chemotherapy for high grade astrocytoma; results of a metaanalysis显示文摘 | Huneharek M Muscat J Geschwind JF | 1998 | Anticancer Res1998，18，6： | 1 |
| 7 | The ecology of Craspedacusta sowerbyi Lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | Am Midl Nat1976，95，： | 1 |
| 8 | Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline显示文摘 | Muscat T R Papp M Willner P | 1992 | Psyckopharmacology(Berl)1992，109，4： | 1 |
| 9 | Serum prostate specific antigen as predictor of staging abdominal/pelvic computered tomograpgy in newly diagnosed prostate cancer显示文摘 | Muscat J | 1996 | Abdon Imaging1996，21，： | 1 |
| 10 | Shakedown analysis for complex loading using superposition显示文摘 | MUSCAT M HAMILTON R BOYLE J r | 2002 | The Journal of Strain Analysis for Engineering Design2002，37，39： | 1 |
| 11 | The ecology of Craspedacusta sowerbii lankester, a freshwater hydrozoan显示文摘 | Acker T S Muscat A M | 1976 | The American Midian Naturalist1976，95，： | 1 |
| 12 | Measles in Europe: an epidemiological assessment显示文摘 | Mark Muscat Henrik Bang Jan Wohlfahrt Steffen Glismann K?re M?lbak | 2009 | The Lancet2009，，9661： | 1 |
| 13 | Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells 显示文摘 | Melissa J Knight Christopher D Riffkin Andrea M Muscat | 2001 | Oncogene2001，20，： | 1 |
| 14 | Planned preopera- tive radiation therapy in muscle invasive bladder cancer: results of a meta-analysis显示文摘 | Huncharek M Muscat J Geschwind JF | 1998 | Anticancer Res1998，18，3： | 1 |
| 15 | Chronic mild stress- induced anhedonia : a realistic animal model of depression 显示文摘 | Willner P Muscat R Papp M | 1992 | Neurosci Biobehav Rev1992，16，4： | 1 |
| 16 | The journey of the pain resource nurse in improving pain management practices:understanding role implementation 显示文摘 | Ladak SS McPhee C Muscat M | 2013 | Pain Manag Nurs2013，14，2： | 1 |
| 17 | Chronic mild stress-induced anhedonia: a realistic animal model of depression 显示文摘 | Willner P Muscat R Papp M | 1992 | Neurosci Biobehav Rev1992，16，： | 1 |
| 18 | Chronic mild stress-induced anhedonia: a realistic animal model of depression 显示文摘 | WILLNER P MUSCAT R PAPP M | 1992 | Neurosci Biobehav Rev1992，16，4： | 1 |
| 19 | K-ras oncogene mutation as a prognostic marker in non-smail-cell lung cancer:A combined analysis of 881 cases显示文摘 | Huncharek M Muscat J Geschwind JF | 1999 | Carcinogenesis1999，20，： | 1 |
| 20 | K-ras oncogene mutation as a prognostic marker in non-small lung cancer:a combined analysis of 881 cases显示文摘 | Huncharek M Muscat J Geschwind JF | 1999 | Carcinogenesis1999，，20： | 1 |
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