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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Comparison of GSTM polymorphisms and risk for oral cance rbetween African-Americans and Caucasians显示文摘 | Park LY Muscat JE Kaur T | 2000 | Pharmacogenetics2000，10，2： | 1 |
| 3 | Handheld cellular telephones and risk of acoustic neuroma显示文摘 | Muscat JE | 2002 | Neurology2002，，58： | 1 |
| 4 | Handheld cellular telephones and risk of acoustic neuroma显示文摘 | Muscat JE Malkin MG Shore RE | 2002 | Neurology2002，58，8： | 1 |
| 5 | Handheld cellular telephone use and risk of brain cancer显示文摘 | Muscat JE Malkin MG Thompson S | 2000 | JAMA2000，284，23： | 1 |
| 6 | Handheld cellular telephone use and risk of brain cancer显示文摘 | Muscat JE Malkin MG Thompson S | 2000 | JAMA2000，284，23： | 1 |
| 7 | Modifiable family and school environmental factors associated with smoking status among adolescents in Guangzhou, China 显示文摘 | Wen X Chen W Muscat JE | 2007 | Prey Med2007，45，23： | 1 |
| 8 | Dietary patterns and colorectal adenoma and cancer risk:a review of the epidemiologi- cal evidence显示文摘 | Miller PE Lesko SM Muscat JE | 2010 | Nutrition and Cancer2010，62，4： | 1 |
| 9 | Smoking and pancreatic cancer in men and women显示文摘 | Muscat JE Stellman SD Hoffmann D | 1997 | Cancer Epidemi- ol Biomarkers Prey1997，6，1： | 1 |
| 10 | Risk of lung carcinoma among users of nonsteroidal anti-inflammatory drugs 显示文摘 | Muscat JE Chen SQ Richie Jr JP | 2003 | Cancer2003，97，： | 1 |
| 11 | Breast cancer: weighing the evidence for a promoting role of dietary Fat 显示文摘 | Wynder EL Cohen LA Muscat JE | 1997 | J Natl Cancer Inst1997，89，11： | 1 |
| 12 | The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk 显示文摘 | Muscat JE Liu liP Livelsberger C | 2012 | Cancer Causes Control2012，23，3： | 1 |
| 13 | Nicotine dependence phenotype and lung cancer risk显示文摘 | Muscat JE Ahn K Richie JP | 2011 | Cancer2011，117，23： | 1 |
| 14 | Nicotine dependence phenotype,time to first cigarette,and risk of head and neck cancer显示文摘 | Muscat JE Ahn K Richie JP | 2011 | Cancer2011，117，23： | 1 |
| 15 | Mobile telephones and rates of brain cancer显示文摘 | Muscat JE Hinsvark M Malkin M | 2006 | 中国神经肿瘤杂志2006，4，3： | 1 |
| 16 | Time to first cigarette and 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) levels in adult smokers ;National tteahh and Nutrition Examina- tion Survey (NHANES),2007-2010显示文摘 | Branstetter SA Muscat JE | 2013 | Cancer Epidemiol Biomarkers Prev2013，22，4： | 1 |
| 17 | Dietary patterns and 650 colorectal adenoma and cancer risk:a review of the epidemiological evidence显示文摘 | Miller PE Lesko SM Muscat JE | | 0，，04： | 1 |
| 18 | tobacco,alcohol,asbestos,and occupational risk factors for laryngeal cancer显示文摘 | Muscat JE wynder EL | 1992 | Cancer1992，69，9： | 1 |
| 19 | Nonsteroidal anti-inflammatory drugs and colorectal cancer显示文摘 | Muscat JE Stellman SD Wymder EL | 1994 | Cancer1994，74，： | 1 |
| 20 | The nicotine dependencephenotype, time to first cigarette, and larynx cancer risk显示文摘 | Muscat JE Liu HP Livelsberger C | 2012 | Cancer Causes Control2012，23，3： | 1 |
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