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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Four decades of continuing innovation with fluorouracil:current and future approaches to fluorouracil chemoradiation therapy显示文摘 | RICH T A SHEPARD R C MOSLEY S T | 2004 | J Clin Oncol2004，22，11： | 1 |
| 3 | Effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | Eldredge E P Holmes Z A Mosley A R Shock C C Stieber T D | | 0，，： | 1 |
| 4 | Constraints to the potential impact of child survival in developing countries显示文摘 | Gadomski A Black R Mosley H | 1990 | Health Policy Plan1990，5，3： | 1 |
| 5 | Ivory Crisp: a potato variety with high tuber solids and cold chipping ability 显示文摘 | Love S L Mosley A R Novy R | 2003 | American Journal of Potato Research2003，80，： | 1 |
| 6 | Innate and adaptive immunity for the pathobiology of Parkinson's disease显示文摘 | Stone D K Reynolds A D Mosley R L | 2009 | Antioxid Redox Signal2009，11，： | 1 |
| 7 | Maitenance Scheduling and Staffing Policies in A Wafer Fabrication Facility显示文摘 | Mosley S A Teyner T Uzsoy R M | 1998 | IEEE Transactions Semiconductor Manufactory1998，11，： | 1 |
| 8 | The effects of transitory water stress on potato tuber stem-end reducing sugar and fry color显示文摘 | ELDREDGE E P HOLMES Z A MOSLEY A R | 1996 | Am Potato J1996，73，： | 1 |
| 9 | Elective surgical removal of migra- ted intrauterine contraceptive devices from within the peritoneal cavi- ty : a comparison between open and laparoscopic removal 显示文摘 | Mosley F R Shahi N Kurer M A | 2012 | JSLS2012，16，2： | 1 |
| 10 | Innate and adaptive immunity for the pathobiology of Parkinson’s disease显示文摘 | STONE D K REYNOLDS A D MOSLEY R L | 2009 | Antioxid Redox Signal2009，11，9： | 1 |
| 11 | Efficacy of behavioral management and patient education on vascular access cleansing compliance in hemodialysis patients显示文摘 | Brantley P J Mosley T H Eisen A R | 1990 | Health Psychology1990，9，： | 1 |
| 12 | Oxidative stress and the pathogenesis of neurodegenerative disorders显示文摘 | Reynolds A Laurie C Lee Mosley R | 2007 | Intern Rev Neurobiol2007，82，： | 1 |
| 13 | Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson\'s disease 显示文摘 | Reynolds A D Stone D K Hutter J A Benner E J Mosley R L Gendelman H E | 2010 | J Immunol2010，184，： | 1 |
| 14 | What1 s all theFLAP about? : 5-lipoxygenase- activating protein inhibitors forinflammatory diseases显示文摘 | Evans J F Ferguson A D Mosley R T ei al | 2008 | Trends Pharmacol Sci2008，29，2： | 1 |
| 15 | Oxidative stress and the pathogenesis of neurodegenerative disorders 显示文摘 | Reynolds A Laurie C Lee Mosley R | 2007 | Intern Rev Neurobiol2007，82，： | 1 |
| 16 | NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery显示文摘 | Nowacek A S Miller R L McMillan J Kanmogne G Kanmogne M Mosley R L | 2009 | Nanomedicine (Lond)2009，4，： | 1 |
| 17 | Constraints to the potential impact of child survival in developing countries显示文摘 | Gadomski A Black R Mosley H | 1990 | Health Policy Plan1990，5，3： | 1 |
| 18 | Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages显示文摘 | Nowacek A S Balkundi S McMillan J Roy U Martinez-Skinner A Mosley R L | 2011 | J Control Rel2011，150，： | 1 |
| 19 | Nitrated falphaf-synu- clein-induced alterations in mieroglia| immunity are regulated by CD4+ T cell subsets 显示文摘 | Reynolds A D Stone D K Mosley R L | 2009 | J Immunol2009，182，7： | 1 |
| 20 | Murine motor and behavior functional evaluations for a?cute 1-methyl-4-phenyl-1, 2, 3, G-tet rahydropyridine (MPTP) intoxication显示文摘 | Hurter-SaundersJ A Gendelman H E Mosley R L | 2012 | J Neuroimmune Pharmacol2012，7，： | 1 |
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