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| 1 | Bile acids:Chemistry,physiology,and pathophysiology显示文摘The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics.They are synthesized by the liver from cholesterol through several complementary pathways that are controlled by mechanisms involving finetuning by the levels of certain bile acid species.Although their best-known role is their participation in the digestion and absorption of fat,they also play an important role in several other physiological processes.Thus,genetic abnormalities accounting for alterations in their synthesis,biotransformation and/or transport may result in severe alterations,even leading to lethal situations for which the sole therapeutic option may be liver transplantation.Moreover,the increased levels of bile acids reached during cholestatic liver diseases are known to induce oxidative stress and apoptosis,resulting in damage to the liver parenchyma and,eventually,extrahepatic tissues.When this occurs during pregnancy,the outcome of gestation may be challenged.In contrast,the physical-chemical and biological properties of these compounds have been used as the bases for the development of drugs and as pharmaceutical tools for the delivery of active agents. | Maria J Monte Jose JG Marin Alvaro Antelo Jose Vazquez-Tato | 2009 | World Journal of Gastroenterology2009，15，7： | 36 |
| 2 | Phytochrome Signaling in Green Arabidopsis Seedlings: Impact Assessment of a Mutually Negative phyB-PIF Feedback Loop显示文摘reversibly 红的(R)/far-red (FR )-light-responsive phytochrome (phy ) photosensory 系统在第一暴露之上在发芽黑暗的幼苗开始 deetiolation 进程到光,和阴影回避过程在充分,在到 vegetational 的暴露之上的 deetiolated 幼苗遮。到驾驶这些回答的 transcriptional 网络的从激活光的光敏电阻器 conformer (Pfr ) 的细胞内部的发信号小径与 bHLH 抄写因素的一个小亚科包含 Pfr 的直接、物理相互作用,称为的交往 Phy 因素(程序信息文件) ,它导致快速的程序信息文件解朊的降级。另外,有在光成年的幼苗的进一步的复杂性的证据, phyBPIF 相互作用由此相互地导致 phyB 降级,在里面一互相否定,反馈环配置。这里,在光成年的幼苗估计这些对抗活动的相对贡献到网 phenotypic 读出,我们检验了 light-shade-induced 的大小和 pentuple phyBpif1pif3pif4pif5 (phyBpifq ) 的 simulated-shade-induced 回答变异、各种各样的多重 pif 变异的联合。数据( 1 )重申 phyB 是占优势不独占,响应延长连续 R 照耀在 deetiolating 幼苗强加胚轴延伸的抑制的光敏电阻器并且( 2 )出现 PIF 四重唱( PIF1 , PIF3 , PIF4 ,并且 PIF5 )保留并且施加一个双能力在这些条件下面调制胚轴延伸由附随地通过内在的transcriptional规章的活动支持房间延伸,并且通过 feedb 减少phyB禁止的能力在暴露阴影的幼苗, immunoblot 分析证明在 Pfr 层次的强加阴影的减小在许多 PIF3 导致增加,并且变异的分析显示 PIF3 行动,到,与 PIF4 和 PIF5 一起支持胚轴延伸的已知的导致阴影的加速。相反地,尽管四倍的 pifq 异种显示清楚地减少了胚轴延伸与相比响应延长色泽野类型, immunoblot 分析不在变异的幼苗在 phyB 层次检测举起与相比在导致阴影的生长时期的多数期间野类型,并且 phyB 层次要用体力地没越过比较的pif变异的联合与生长显型被相关。这些结果建议 phyB 丰富的程序信息文件反馈调整不在在这些下面的支持程序信息文件的、阴影应答的显型的大小调节的 modulating 起一个主导的作用。在成长在下面的幼苗日报 lightdark 周期,在黑暗经期(End-of-Day-FR (EOD-FR ) 治疗) 的开始的 Pfr 的 FR-pulse-induced 移动相对没有 EOD-FR 治疗导致更长的胚轴并且这效果在 pif 变异的联合被稀释的数据表演测试了。这结果同样显示 PIF 四重唱成员能够内在地在光成年的植物支持胚轴房间延伸,独立于 photoactivated-phyB 丰富的程序信息文件反馈调整的效果。 | Pablo Leivar Elena Monte Megan M. Cohn Peter H. Quail | 2012 | Molecular Plant2012，5，3： | 20 |
| 3 | Coronary thrombus in patients undergoing primary PCI for STEMI:Prognostic significance and management显示文摘Acute ST-elevation myocardial infarction(STEMI) usually results from coronary atherosclerotic plaque disruption with superimposed thrombus formation. Detection of coronary thrombi is a poor prognostic indicator,which is mostly proportional to their size and composition. Particularly,intracoronary thrombi impair both epicardial blood flow and myocardial perfusion,by occluding major coronary arteries and causing distal embolization,respectively. Thus,although primary percutaneous coronary intervention is the preferred treatement strategy in STEMI setting,the associated use of adjunctive antithrombotic drugs and/or percutaneous thrombectomy is crucial to optimize therapy of STEMI patients,by improving either angiographical and clinical outcomes. This review article will focus on the prognostic significance of intracoronary thrombi and on current antithrombotic pharmacological and interventional strategies used inthe setting of STEMI to manage thrombotic lesions. | Sabine Vecchio Elisabetta Varani Tania Chechi Marco Balducelli Giuseppe Vecchi Matteo Aquilina Giulia Ricci Lucchi Alessro Dal Monte Massimo Margheri | 2014 | World Journal of Cardiology2014，6，6： | 18 |
| 4 | Inflammation in irritable bowel syndrome:Myth or newtreatment target?显示文摘Low-grade intestinal inflammation plays a key role in the pathophysiology of irritable bowel syndrome(IBS), and this role is likely to be multifactorial. The aim of this review was to summarize the evidence on the spectrum of mucosal inflammation in IBS, highlighting the relationship of this inflammation to the pathophysiology of IBS and its connection to clinical practice. We carried out a bibliographic search in Medline and the Cochrane Library for the period of January 1966 to December 2014, focusing on publications describing an interaction between inflammation and IBS. Several evidences demonstrate microscopic and molecular abnormalities in IBS patients. Understanding the mechanisms underlying low-grade inflammation in IBS may help to design clinical trials to test the efficacy and safety of drugs that target this pathophysiologic mechanism. | Emanuele Sinagra Giancarlo Pompei Giovanni Tomasello Francesco Cappello Gaetano Cristian Morreale Georgios Amvrosiadis Francesca Rossi Attilio Ignazio Lo Monte Aroldo Gabriele Rizzo Dario Raimondo | 2016 | World Journal of Gastroenterology2016，22，7： | 16 |
| 5 | Device interchangeability on anterior chamber depth and white-to-white measurements: a thorough literature review显示文摘We have reviewed a set of recently published studies that compared the anterior chamber depth(ACD) and/or white-to-white(WTW) distance obtained by means of different measuring devices.Since some of those studies reached contradictory conclusions regarding device interchangeability,this review was carried out in attempting to clarify which clinical devices can or cannot be considered as interchangeable in clinical practice to measure ACD and/or WTW distance,among these devices:A-scan,ultrasound biomicroscopy,Orbscan and Orbscan Ⅱ(Bausch&Lomb Surgical Inc.,San Dimas,California,USA),Pentacam and Pentacam HR(Oculus,Wetzlar,Germany),Galilei(Ziemer,Switzerland),Visante optical coherence tomography(Visante OCT,Carl Zeiss Meditec Inc.,Dublin,California,USA),lOLMaster(Carl Zeiss Meditec,Jena,Germany),and Lenstar LS 900/Biograph(Haag-Streit AG,Koeniz,Switzerland/Alcon Laboratories Inc.,Ft Worth,Texas,USA). | Alberto Domínguez-Vicent Cari Pérez-Vives Teresa Ferrer-Blasco Santiago García-Lázaro Robert Montés-Micó | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 13 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | A rationale for the development of thermally stable nanostructured CeO_2-ZrO_2-containing mixed oxides显示文摘CeO2-ZeO2 solid solutions are extensively used as oxygen storage promoters in the current automotive three-way catalysts. High thermal stability of the textural properties is one of the most important requirements for practical application since temperatures up to 1273 K are easily experienced by these materials under real working conditions. In the present paper, we investigated how hydrothermal treatments applied to cakes of doped and undoped ZrO2-rich CeO2-ZrO2 precursors might improve the thermal stability of the final CeO2-ZrO2 solid so- lution. A rationale was developed that allowed to correlate the morphology of the hydrothermally treated cake with the thermal stability at 1273 K of the final product, which did not depend on the composition of the mixed oxides. | Roberta Di Monte Jan Kapar Heather Bradshaw Colin Norman | 2008 | Journal of Rare Earths2008，26，2： | 10 |
| 8 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 9 | 择期髋膝关节置换患者静脉血栓栓塞性疾病预防的AAOS指南显示文摘本临床实践指南是对2007年已发表的一个类似指南进行撤换。我们根据现有的文献,对患者的筛选,危险因素的评估,静脉血栓疾病(VTED)的预防性治疗,鼓励患者术后活动以及使用椎管内麻醉和下腔静脉过滤器等各方面进行了评估。我们建议对有静脉血栓栓塞性疾病病史但没有其他潜在危险因素的患者需要进行进一步的评估,患者应评估是否患有某些已知的出血性疾病以及是否存在活动性的肝脏疾病。没有VTED或出血高风险的患者也应接受药物及机械压缩装置来预防VTED的发生,但我们并没有推荐具体的药物和/或机械装置。我们建议,行择期髋膝关节置换术的患者术后应进行早期活动。采用椎管内麻醉有助于减少失血,但没有发现椎管内麻醉会影响VTED发生的证据。目前也没有明确的证据表明对有药物预防禁忌和/或已知VTED的患者使用下腔静脉过滤器能防止肺栓塞的发生。 | Mont MA Jacobs JJ 余霄 俞光荣 | 2012 | 中华关节外科杂志(电子版)2012，6，4： | 6 |
| 10 | Pancreatitis after endoscopic retrograde cholangiopancreatography:A narrative review显示文摘Acute post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP)is a feared and potentially fatal complication that can be as high as up to 30%in high-risk patients.Pre-examination measures,during the examination and after the examination are the key to technical and clinical success with a decrease in adverse events.Several studies have debated on the subject,however,numerous topics remain controversial,such as the effectiveness of prophylactic medications and the amylase dosage time.This review was designed to provide an update on the current scientific evidence regarding PEP available in the literature. | Igor Braga Ribeiro Epifanio Silvino do Monte Junior Antonio Afonso Miranda Neto Igor Mendonça Proença Diogo Turiani Hourneaux de Moura Mauricio Kazuyoshi Minata Edson Ide Marcos Eduardo Lera dos Santos Gustavo de Oliveira Luz Sergio Eiji Matuguma Spencer Cheng Renato Baracat Eduardo Guimarães Hourneaux de Moura | 2021 | World Journal of Gastroenterology2021，27，20： | 5 |
| 11 | Active compounds of medicinal plants,mechanism for antioxidant and beneficial effects显示文摘An increased interest in the antioxidant effects of medicinal plants has developed in recent years.Identifying antioxidant compounds present in medicinal plants and elucidating the mechanism by which they prevent oxidation have been the focus of the research community.We performed a systematic and exhaustive review aimed at analyzing the available data regarding the beneficial effects of secondary metabolites in plants.The result of this review is presented as a description of free radicals,as well as cellular and physiological oxidative stress,is provided.The origin and source of antioxidant compounds,and the cellular and molecular mechanism by which they exert antioxidant effects,have been reported.The absorption,distribution and,elimination of antioxidants are mentioned.The beneficial effects of secondary metabolites of medicinal plants in various high incidence disease conditions were also reviewed.Finally,disease states that benefit from antioxidant compounds includes diabetes,cancer,cardiovascular diseases,and liver,brain and,intestinal diseases. | Orozco Montes F A Vázquez-Hernández B Fenton-Navarro | 2019 | Phyton-International Journal of Experimental Botany2019，88，1： | 5 |
| 12 | Intraoperative laparoscopic complications for urological cancer procedures显示文摘AIM: To structure the rate of intraoperative complications that requires an intraoperative or perioperative resolution. METHODS: We perform a literature review of Medline database. The research was focused on intraoperative laparoscopic procedures inside the field of urological oncology. General rate of perioperative complications in laparoscopic urologic surgery is described to be around 12.4%. Most of the manuscripts published do not make differences between pure intraoperative, intraoperative with postoperative consequences and postoperative complications. RESULTS: We expose a narrative statement of complications, possible solutions and possible preventions for most frequent retroperitoneal and pelvic laparoscopic surgery. We expose the results with the following order: retroperitoneal laparoscopic surgery(radical nephrectomy, partial nephrectomy, nephroureterectomy and adrenalectomy) and pelvic laparoscopic surgery(radical prostatectomy and radical cystectomy).CONCLUSION: Intraoperative complications vary from different series. More scheduled reports should be done in order to better understand the real rates of complications. | Sergio Fernández-Pello Montes Ivan Gonzalez Rodríguez Rodrigo Gil Ugarteburu Luis Rodríguez Villamil Begoa Diaz Mendez Patricio Suarez Gil Javier Mosquera Madera | 2015 | World Journal of Clinical Cases2015，3，5： | 4 |
| 13 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 14 | Accelerating phase-field-based microstructure evolution predictions via surrogate models trained by machine learning methods显示文摘The phase-field method is a powerful and versatile computational approach for modeling the evolution of microstructures and associated properties for a wide variety of physical,chemical,and biological systems.However,existing high-fidelity phase-field models are inherently computa fonally expensive,requiring high-performance computing resources and sophisticated numefical integration schemes to achieve a useful degree of accuracy.In this paper,we present a computationally inexpensive,accurate,data-driven surmogate model that directly learns the microstructural evolution of targeted systems by combining phase-field and history-dependent machine-learning techniques.We integrate a statisti cally representative,low-dimensianal description of the micrastructure,obtained direcdy from phase-field simulations,with either a time-series multivariate adaptive regression splines autoregressive al garithm or a lang short-term memory neural network.The neural-network-trained surrogate model shows the bestperformance and accurately predicts the nanlinear microstructure evolutian of a two-phase mixture during spinodal decomposition in seconds,without the need for'on-the-fly'solutions of the phase-field equations of motion.We also show that the predictions from our machine learned surrogate model can be fed directly as an input into a classical high-fideli ty phase-field model in order to accelerate the high-fidelity phase field simulations by leaping in time.Such machine-learned phase-field framework opens a promising path forward to use accelerated phase field simulations for discovering,understanding,and predicting processing-microstructure-performance relationships. | David Montes de Oca Zapiain James A.Stewart Rémi Dingreville | 2021 | npj Computational Materials2021，，1： | 4 |
| 15 | 克服连铸结晶器液面周期性扰动的新型控制方法显示文摘韩国浦项光阳厂的板坯连铸机应用液面控制系统UCN3000。该系统基于模块设计,包含了一系列针对特殊液面控制优化的模块。基于模糊技术的管理器能在线识别结晶器液面的干扰并切换到合适的模块单元。采用这种控制方法使液面波动幅度约比原来减少50%。 | Michel Dussud Franck Montégu Goohwa Kim 洪杰(摘译) 焦四海(校) | 2006 | 世界钢铁2006，6，6： | 4 |
| 16 | Antimicrobial susceptibility testing before first-line treatment for Helicobacter pylori infection in patients with dual or triple antibiotic resistance显示文摘AIM To evaluate the efficacy of antimicrobial susceptibilityguided therapy before first-line treatment for infection in patients with dual or triple antibiotic resistance.METHODS A total of 1034 patients infected by Helicobacter pylori(H. pylori) during 2013-2014 were tested for antimicrobial susceptibility. 157 of 1034(15%) patients showed resistance to two(127/1034; 12%) and to three(30/1034; 3%) antibiotics. Sixty-eight patients with dual H. pylori-resistance(clarithromycin, metronidazole or levofloxacin) were treated for 10 d with triple therapies: OAL(omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and levofloxacin 500 mg b.i.d.) 43cases, OAM(omeprazole 20 mg b.i.d., amoxicillin 1 g b.i.d., and metronidazole 500 mg b.i.d.) 12 cases and OAC(omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and clarithromycin 500 mg b.i.d.) 13 cases based on the antimicrobial susceptibility testing. Twelve patients showed triple H. pylori-resistance(clarithromycin, metronidazole and levofloxacin) and received for 10 d triple therapy with OAR(omeprazole 20 mg b.id., amoxicillin 1 g b.i.d., and rifabutin 150 mg b.i.d.). Eradication was confirmed by 13C-urea breath test. Adverse effects and compliance were assessed by a questionnaire. RESULTS Intention-to-treat eradication rates were: OAL(97.6%), OAM(91.6%), OAC(92.3%) and OAR(58.3%). Cure rate was significantly higher in na?ve patients treated with OAR-10 compared to patients who had two or three previous treatment failures(83% vs 33%). Adverse events rates for OAL, OAM, OAC and OAR were 22%, 25%, 23% and 17%, respectively, all of them mild-moderate. CONCLUSION Antimicrobial susceptibility-guided triple therapies during 10 d for first-line treatment leads to an eradication rate superior to 90% in patients with dual antibiotic H. pylori resistance. | Angel Cosme Milagrosa Montes Begona Ibarra Esther Tamayo Horacio Alonso Usua Mendarte Jacobo Lizasoan Marta Herreros-Villanueva Luis Bujanda | 2017 | World Journal of Gastroenterology2017，23，18： | 4 |
| 17 | Focus on intracytoplasmic morphologically selected sperm injection (IMSI). a mini-review显示文摘Intracytoplasmic 精子注射(ICSI ) 是在坏分子不孕的许多情况中的推荐治疗。几研究表明了在最佳的精子形态学和积极 ICSI 结果之间的积极关联。事实上,有头的严重畸形的精子很好被记录与低使肥沃,培植和怀孕率被联系。然而,作为 ‘ 被分类的一个精子;由在低放大的显微镜的观察的 normal' 能包含损害使肥沃过程和胚胎的开发的 ultrastructural 缺点。intracytoplasmic 词法上选择了注射(IMSI ) 过程改变了的精子对注射合适的一个精子应该显得怎么样的感觉。精子选择在 × 被执行; 6000 放大,允许改进了对精子原子核的评价。当前,标准化了临床的指示因为 IMSI 正在缺乏,候选人在他们的病历或精子暂停的小心的分析的根据上被选择。进一步未来的使随机化的研究被需要在病人的特定的组证实 IMSI 的优点。除了提供 IMSI 过程的简短概述,这研究试图考察文学,它解释理论基础和这种技术的临床的结果。IMSI 与改进培植和临床的怀孕被联系的几报告表演象更低的流产率一样评价什么时候与 ICSI 相比。尽管在精子的反常原子核形状,增加的 DNA 破碎和否定实验室和临床的结果之间的可能的关联长被调查了,结果正在冲突。 | Giuseppe Lo Monte Fabien Murisier Isabella Piva Marc Germond Roberto Marci | 2013 | Asian Journal of Andrology2013，15，5： | 3 |
| 18 | 低剂量左旋布比卡因3mg复合芬太尼10μg脊髓麻醉在妇科门诊腹腔镜手术中的应用显示文摘背景对于妇科门诊腹腔镜这种短时手术来说,选择利多卡因进行脊髓麻醉是十分有效的。本研究中,我们对比了利多卡因.芬太尼与左旋布比卡因-芬太尼脊髓麻醉在短时妇科腹腔镜手术中的麻醉效果、麻醉恢复时间和患者满意度。方法在这项双盲研究中,52例拟行输卵管绝育术的健康妇女被随机分为组Ⅰ(椎管内注射2%利多卡因10mg加芬太尼10μg)和组Ⅱ(椎管内注射0.5%左旋布比卡因3mg加芬太尼10μg),每组药物用灭菌水稀释至3ml。术中需要监测以下指标:麻醉起效时间、是否需要补充麻醉一镇痛药物、镇静深度、手术条件以及血流动力学方面的事件。术后,通过测试运动阻滞情况、本体感觉、振动觉、轻触觉和进行Romberg试验来评估患者是否可以不去麻醉恢复室并独立行走。麻醉给药后5、10、15分钟测试感觉阻滞平面,之后每15分钟测试一次直至感觉完全恢复。感觉阻滞恢复时间的差异达25分钟被认为在临床上是有意义的。结果两组的麻醉起效时间和术中条件相同。没有患者需要全身麻醉来完成手术。所有两组患者都不需要去麻醉恢复室。组Ⅰ患者在27分钟(18-45分钟)后可行走,组Ⅱ30分钟(18。56分钟)后可行走(P=0.24)。脊髓麻醉完全恢复组Ⅰ需要93分钟(65-120分钟),组Ⅱ需要105分钟(78-150分钟)(P=0.019);然而,出院时间两组没有区别,组Ⅰ为185分钟(150-300分钟),组Ⅱ为188分钟(125-300分钟)(P=0.62)。两组患者的总体满意度也相似。结论左旋布比卡因3mg复合芬太尼10μg可以替代利多卡因10mg复合芬太尼10μg用于短时手术的脊髓麻醉。前者在临床中可以达到与后者相当的感觉阻滞恢复时间、术中条件和患者满意度。 | Jesus de Santiago, DESA, MD Javier Santos,Yglesias, MD Jorge Giron, MD Frandsco Montes de Oca, MD Alejandro Jimenez, PhDl Pilar Diaz, PhD | 2012 | 麻醉与镇痛2012，8，1： | 3 |
| 19 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 20 | Current and future circulating biomarkers for cardiac amyloidosis显示文摘心脏的淀粉样变性病(CA ) 包括影响心肌层的医药条件的一个异构的组。它与严厉,流行和进化的可变的度与 proteinaceous 介绍渗入。尽管有这异质,错误的蛋白质合拢是普通 pathophysiologic 过程,产出日益增多地发展并且最终形成淀粉的纤维的单个错误褶层蛋白质(单体) 的形成。由从起源的机关外面播种,另外,称为 oligomers 的中介转移并且重启这个过程。如此的自我回应的行为象主要的一样使第二等的影响机关重要。不幸地, CA 能在它的自然历史的一个迟了的阶段临床上挑战性、仅仅暗示,让一扇狭窄的治疗学的时间窗户可得到。考虑到淀粉样变性病的进化性质,这里,我们越过 CA 子类型与不同特性和适用性基于时间舞台建议当前使用的 biomarkers 的一个新分类。早标记(免费的轻链,浆液淀粉的 A, 2-microglobulin, osteopontin 和 osteoprotegerin ) 能为疾病察觉被采用。中间的标记[tumorigenicity 的可溶的抑制 2 (sST-2 ) , midregional proadrenomedullin (MR-proADM ) , von Willebrand 因素(vWF ) , hepatocyte 生长因素(HGF ) ,矩阵 metalloproteinases (MMP ) 和织物禁止者 metalloproteinases (TIMP )] 能在心肌的损坏的生物机制上提供信息。作为在心失败,迟了阶段的 biomarkers (troponins 和 natriuretic 肽) 能在 CA 帮助临床医生做好预后和治疗学的反应评估。如此的调查结果在 CA 上为我们的当前的知识产生了一个显著基础。不过,我们想象目标为能够检测合拢缺点的在上游的事件的 biomarkers 的一个未来班,它将最终扩展治疗学的窗户。 | Marco LUCIANI Luca TRONCONE Federica DEL MONTE | 2018 | Acta Pharmacologica Sinica2018，39，7： | 3 |
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