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| 1 | Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression. | Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 2 | Hematological recovery in Sparus aurata after bleeding显示文摘 | Montero D Tort L Lzquierdo M S | 1995 | Rev Esp Fis1995，51，： | 1 |
| 3 | High stocking density producers crowding stress altering some physiological and biochemical parameters in gilthead seabream,Sparus aurata juveniles显示文摘 | Montero D Izquier M S Tort L | 1999 | Fish Physiology and Biochemistry1999，20，： | 1 |
| 4 | High stocking density produces crowding stress altering some physiological and biochemical parameters in gilthead seabream, Sparus aurata juveniles 显示文摘 | Montero D Izquierdo M S Tort L Robaina L | 1999 | Fish Physiology and Biochemistry1999，20，： | 1 |
| 5 | Depletion of serum alternative complement pathway activity in gilthead seabream caused by α-to copherol and n-3 HUFA deficiencies显示文摘 | Montero D Tort L Izquierdo M S | 1998 | Comp Biochem Physiol1998，18，： | 1 |
| 6 | Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms 显示文摘 | Walsh D T Montero R M Bresciani L G | 2002 | Neurobiol Dis2002，10，1： | 1 |
| 7 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 8 | PCR tools for the differential diagnosis of Taenia saginata and Taenia solium taeniasis/cysticercosis from different geographical locations显示文摘 | Gonzalez L M Montero E Puente S | 2002 | Diagn Microbiol Infect Dis2002，42，： | 1 |
| 9 | High stocking density produces crowding stress altering some physiological and biochemical parameters in gilthead seabream, Sparus aurata,juveniles显示文摘 | Montero D Izquierdo M S Tort L | 1999 | Fish Physiol Biochem1999，20，1： | 1 |
| 10 | High stocking density produces crowding stress altering some physiological and biochemical parameters in gilthead seabream, Sparus aurata, juveniles 显示文摘 | MONTERO D IZQUIERDO M S TORT L | 1999 | Fish Physiol Biochem1999，20，1： | 1 |
| 11 | Micro structural behavior and gelling characteristics of myosystem protein gels interacting with hydrocolloids显示文摘 | MONTERO P HURTADO J L PEREZ-MATEOS M | 2000 | Food Hydrocolloids2000，14，： | 1 |
| 12 | High stocking density producers crowding stress altering some physiological and biochemical parameters in gilthead seabream,Sparus aurata juveniles显示文摘 | Montero D Izquier M S Tort L Robaina L | 1999 | Fish Physiology and Biochemistry1999，20，： | 1 |
| 13 | Retinal detach- ment in myopic eyes after phakic intraocular lens implanta- tion显示文摘 | RUIZ J M MONTERO J A ALIO J L | 2006 | J Refract Surg2006，22，3： | 1 |
| 14 | High stocking density produces crowding stress altering some physiological and biochemical parameters in gilthead seabream, Sparus aurata, juveniles显示文摘 | Montero D Izquierdo M S Tort L | 1999 | Fish Physiol Biochem1999，20，1： | 1 |
| 15 | Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors显示文摘 | Jiang Y Ming L Montero AJ Kimchi E Nikfarjam M Staveley-O'Carroll KF | 2008 | Gastrointest Cancer Res2008，2，5： | 1 |
| 16 | High stocking density produces crowding stress altering some physiological and biochemical parameters in gilthead sea bream, Sparus aurata, juveniles显示文摘 | MONTERO D IZQUIERDO M S TORT L | 1999 | Fish Physiol Biochem1999，20，： | 1 |
| 17 | Effectiveness and safety ofcolistin for the treatment of multidrug-resistant Pseudomonas aerug-inosa infections显示文摘 | Montero M Horcajada JP SorlíL | 2009 | Infection2009，37，5： | 1 |
| 18 | Microstructural behaviour and gelling characteristics of myosystem protein gels interacting with hydrocolloids显示文摘 | Montero P Hurtado J L Perez-mateos M | | 0，，： | 1 |
| 19 | BGN163,a novel acidic bets-1-6-glucanase from mycoparasitic fungus Trichoderma harzianum CECT 2413显示文摘 | Montero M Sanz L Rey M | 2005 | FEBS J2005，272，： | 1 |
| 20 | Autolysis and protease inhibition effects on dynamic viscoelastic properties during thermal gelation of squid muscle显示文摘 | Gomez-Guillen M C Hurtado J L Montero P | 2002 | Journal of Food Science2002，67，7： | 1 |
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