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| 1 | Proteomic analysis for developing new biomarkers of hepatocellular carcinoma显示文摘AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcoholic liver disease, were included in the study. The samples were analysed by 2D-electrophoresis in order to determine the differential protein expression. The proteins were separated according to the charge in immobilized pH 3-10 gradient strips and then by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Proteins of interest were excised, digested with trypsin and the resulting peptides were separated and identified. RESULTS: Three differentially expressed apolipoproteins (Apo) were identified based on the protein profile using proteomic techniques: Apo-A1, Apo-A4 and Apo-E. Apo-A4 levels were significantly lower in HCC than in non-HCC patients regardless of etiology (P < 0.01). Multivariate logistic regression showed that Apo-A4 and Apo-A1 were the only independent factors related to HCC diagnosis (P < 0.05). The receiver operating characteristic (ROC) curve including both Apo-A4 and Apo-A1 showed an area under the ROC of 0.944 (P < 0.001), a sensitivity of 0.89 and a specificity of 0.81 for diagnosis of HCC. CONCLUSION: Apo-A4 and Apo-A1 may be used clinically as biomarkers of HCC with a high sensibility and specificity. These findings may provide additional insights into the mechanism of HCC development and progression. | Maria Pleguezuelo Laura M Lopez-Sanchez Antonio Rodriguez-Ariza Jose L Montero Javier Briceno Ruben Ciria Jordi Muntane Manuel de la Mata | 2010 | World Journal of Hepatology2010，2，3： | 3 |
| 2 | 1%依柏康唑乳膏治疗皮肤浅部真菌病安全有效:与2%咪康唑乳膏比较的多中心、随机、双盲临床试验显示文摘Background: Eberconazole is a topical, broad-spectrum imidazole derivative, effective in dermatophytoses, candidiasis, and pityriasis treatment. In previous trials, it showed a higher efficacy than clotrimazole in the treatment of dermatophytoses. The purpose of this trial was to evaluate the efficacy of eberconazole 1% cream compared with miconazole 2% cream in the treatment of dermatophytoses. Methods: A multicenter, double-blind, randomized trial was performed in 653 patients with dermatophytoses, randomized to eberconazole 1% cream every 12 h or miconazole 2% cream every 12 h for 4 weeks. Treatment efficacy was assessed on the basis of the percentage of effective response after 4 weeks through mycologic and clinical assessment. Results: Of the 653 patients included in the trial, 360 produced positive baseline mycologic cultures and were included in the efficacy assessment. Clinical efficacy was shown in 76.1% of patients receiving eberconazole and in 75.0% of patients receiving miconazole. The incidence of adverse events related to treatment was 0.91% for eberconazole and 0.92% for miconazole, none being serious, and all being local and transient. Conclusions: Eberconazole 1% cream is an effective treatment for fungal infections produced by dermatophytes, with a good safety and tolerability profile, and can be considered a good alternative for the treatment of dermatophytoses. | Montero T.R. López S. Rodrguez C. 李政霄 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，2，8： | 2 |
| 3 | Detection Limits of Antimicrobials in Ewe Milk by Delvotest Photometric Measurements显示文摘 | Althaus R L TorresA Montero A | 2003 | J Dairy Sci2003，86，2： | 1 |
| 4 | Characterization of Pd-CeO2 interaction on alumina support and hydrogenation of 1,3-butadiene显示文摘 | Montero R D S Noronha F B DIeguez L C | 1995 | Appl Catal A1995，131，1： | 1 |
| 5 | E-Learning XML:Towards a model-based approach for the development of e-Learning systems considering quality显示文摘 | Habib Fardoun Francisco Montero Víctor López Jaquero | | 0，，12： | 1 |
| 6 | Detection Limits of Antimicrobial Agents in Ewe Milk by Delvotestm显示文摘 | Althaus R L Peris C Montero A | 2002 | Milchwissenschaft2002，57，1112： | 1 |
| 7 | Serum haermolytic and agglutinating activity as indicators of fish immunocompetence:their suitabiIity in stress and dietary studies 显示文摘 | TORT L GOMEZ E MONTERO D S | 1996 | Aquacuhure International1996，，4： | 1 |
| 8 | Hematological recovery in Sparus aurata after bleeding显示文摘 | Montero D Tort L Lzquierdo M S | 1995 | Rev Esp Fis1995，51，： | 1 |
| 9 | Sunflower protein films incorporated with clove essential oil have potential application for the preservation of fish patties显示文摘 | Pablo R. Salgado M. Elvira López-Caballero M. Carmen Gómez-Guillén Adriana N. Mauri M. Pilar Montero | 2013 | Food Hydrocolloids2013，，1： | 1 |
| 10 | Optimizing imatinib mesylate treatment in gastrointestinal stromal tumors 显示文摘 | Jiang Y Ming L Montero AJ | 2008 | Gastrointest Cancer Res2008，2，5： | 1 |
| 11 | Transpiration from geranium growth under high temperatures and low humidities in greenhouses显示文摘 | Montero J L | 2001 | Agricultural and Forest Meteorology2001，107，： | 1 |
| 12 | High stocking density producers crowding stress altering some physiological and biochemical parameters in gilthead seabream,Sparus aurata juveniles显示文摘 | Montero D Izquier M S Tort L | 1999 | Fish Physiology and Biochemistry1999，20，： | 1 |
| 13 | High stocking density produces crowding stress altering some physiological and biochemical parameters in gilthead seabream, Sparus aurata juveniles 显示文摘 | Montero D Izquierdo M S Tort L Robaina L | 1999 | Fish Physiology and Biochemistry1999，20，： | 1 |
| 14 | Characterization of Pd-CeO2 interaction on alumina support and hydrogenation of 1,3- butadiene显示文摘 | MONTERO R D S NORONHA F B DIEGUEZ L C | 1995 | Appl Catal A1995，131，1： | 1 |
| 15 | Low vitamin E in diet reduces stress resistance of gilthead seabream (Sparus aurata) juveniles显示文摘 | Montero D Tort L Robaina L | 2001 | Fish Shellfish Immunol2001，11，47： | 1 |
| 16 | Detection Limits of Antimicrobials in Ewe Milk by Delvotest Photometric Measurements显示文摘 | Althaus R L Torres A Montero A | 2003 | J Dairy Sci2003，86，2： | 1 |
| 17 | Depletion of serum alternative complement pathway activity in gilthead seabream caused by α-to copherol and n-3 HUFA deficiencies显示文摘 | Montero D Tort L Izquierdo M S | 1998 | Comp Biochem Physiol1998，18，： | 1 |
| 18 | Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms 显示文摘 | Walsh D T Montero R M Bresciani L G | 2002 | Neurobiol Dis2002，10，1： | 1 |
| 19 | Polydimethylsi- loxane rod extraction, a novel technique for the determination of organic micropollutants in water samples by thermal desorp- tion-capillary gas chromatography-mass spectrometry显示文摘 | MONTERO L POPP P PASCHKE A | 2004 | Jour- nal of Chromatography A2004，1025，1： | 1 |
| 20 | Promot- er specific transcription inhibition in Staphylococcus aureus by a phage protein显示文摘 | Osmundson J Montero Diez C Westblade L F | 2012 | Cell2012，151，5： | 1 |
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