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| 1 | Molecular classifications of gastric cancers: Novel insights and possible future applications显示文摘Despite some notable advances in the systemic management of gastric cancer(GC), the prognosis of patients with advanced disease remains overall poor and their chance of cure is anecdotic. In a molecularly selected population, a median overall survival of 13.8 mo has been reached with the use of human epidermal growth factor 2(HER2) inhibitors in combination with chemotherapy, which has soon after become the standard of care for patients with HER2-overexpressing GC. Moreover, oncologists have recognized the clinical utility of conceiving cancers as a collection of different molecularlydriven entities rather than a single disease. Several molecular drivers have been identified as having crucial roles in other tumors and new molecular classifications have been recently proposed for gastric cancer as well. Not only these classifications allow the identification of different tumor subtypes with unique features, but also they serve as springboard for the development of different therapeutic strategies. Hopefully, the application of standard systemic chemotherapy, specifictargeted agents, immunotherapy or even surgery in specific cancer subgroups will help maximizing treatment outcomes and will avoid treating patients with minimal chance to respond, therefore diluting the average benefit. In this review, we aim at elucidating the aspects of GC molecular subtypes, and the possible future applications of such molecular analyses. | Silvio Ken Garattini Debora Basile Monica Cattaneo Valentina Fanotto Elena Ongaro Marta Bonotto Francesca V Negri Rosa Berenato Paola Ermacora Giovanni Gerardo Cardellino Mariella Giovannoni Nicoletta Pella Mario Scartozzi Lorenzo Antonuzzo Nicola Silvestris Gianpiero Fasola Giuseppe Aprile | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 5 |
| 2 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 3 | Involvement of DNA methylation in tree development and micropropagation显示文摘 | Luis V Rodrigo H Monica M | 2007 | Plant Cell Tiss Organ Cult2007，91，2： | 1 |
| 4 | Mutagenicity of commercial Moanscus fermentation products and the role of citrinin contamination显示文摘 | Monica S V | 1999 | Mutation Research1999，444，： | 1 |
| 5 | Different strategies to develop an electrochemical thrombin aptasensor显示文摘 | Monica M Mark V Katakis I | 2006 | Electrochem Commun2006，8，： | 1 |
| 6 | Requirement for IGF-I in Epidermal Growth Factor-Mediated Cell Cycle Progression of Mammary Epithelial Cells显示文摘 | MALINDA A S MONICA M R AIMEE V L | 2002 | Endocrinology2002，143，5： | 1 |
| 7 | Quantitative determi-nation of the macrolide antibiotic tulathromycin in plasma and bronchoalve-olar cells of foals using tandem mass spectrometry显示文摘 | EBERHARD S A JANINA S A MONICA V B | 2007 | Journal of Chroma-tography B2007，850，12： | 1 |
| 8 | Interleukin 17A is dis- pensable for myocarditis but essential for the progression to dilat- ed cardiomyopathy显示文摘 | Christian B Jobert G Monica V | 2010 | Circ Res2010，106，10： | 1 |
| 9 | p63 and p73 iso form expression in non small cell lung cancer and correspond- ing morphological normal lung tissue显示文摘 | Iacono ML Monica V Saviozzi S | 2011 | J Thorac Oncol2011，6，： | 1 |
| 10 | Evolution of hydrophobic polypeptides during the ageing of exudative and non-exudative pork meat显示文摘 | Javier Moya V Monica F | 2001 | Meat Science2001，57，： | 1 |
| 11 | Characterization ofbacterial populations in Danish raw milk cheeses madewith different starter cultures by denaturating gradient gelelectrophoresis and pyrosequencing显示文摘 | Wafa M Monica T Finn K V | 2011 | InternationalDairy Journal2011，21，： | 1 |
| 12 | A cycloartane trit- erpenoid and co-phenyl alkanoic and alkenoic acids from Trichilia claussenii 显示文摘 | MONICA T P PAULO C V JOEO B F | 1996 | Phytochemistry1996，42，3： | 1 |
| 13 | Effec- tiveness of buffer strips in removing pollutants in runoff from a cultivated field in North-East Italy显示文摘 | MAURIZIO B MONICA V FRANCESCO M | 2005 | Agriculture Ecosystem and Environment2005，102，12： | 1 |
| 14 | Performance comparison of Gaussian-based filters using information measures显示文摘 | MAHESH V MONICA F B Petar M D | 2007 | IEEE Signal Processing Letters2007，14，12： | 1 |
| 15 | Efficiency and capacity of antioxidant rich foods in trapping peroxyl radicals:A full evaluation of radical scavenging activity显示文摘 | Paola V Monica R Veronica de M | 2011 | Food research International2011，44，1： | 1 |
| 16 | Effectiveness of buffer strips in removing pollutants in runoff from a cultivated field in North-East Italy显示文摘 | Maurizio B Monica V Francesco M | 2005 | Agriculture Ecosystems and Environment2005，105，： | 1 |
| 17 | ATF2 contri- butes to cisplatin resistance in non-small cell lung cancerand celastrol induces cisplatin resensitization through in- hibition of JNK/ATF2 pathway显示文摘 | Lo Iacono M Monica V Scagliotti GV | 2015 | Int J Cancer2015，136，11： | 1 |
| 18 | Multiresidue determination of tetracyclines,sulphonamides and chloramphenicol in bovine milk using HPLC-DAD显示文摘 | Monica C V M Felix GRR Sunsanne R | 2009 | Food Chemistry2009，117，3： | 1 |
| 19 | Impact of gold mining on the environment and human health:a case study in the Migori gold belt,Kenya显示文摘 | Jason S O Winnie V M Monica A O | 2002 | Environmental Geochemistry and Health2002，24，： | 1 |
| 20 | 3, 4-Dicholoroaniline acute toxicity in male Fischer 344 rats显示文摘 | Monica A V Tagouri Y John G B | 1997 | Toxicology1997，124，： | 1 |
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