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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | Evaluation of analytical models for thermal analysis and design of electronic packages 显示文摘 | Moghaddam S Rada M Shooshtari A | 2003 | Microelectron J2003，34，： | 1 |
| 3 | Chemical constituents of dichloromethane extract of cultivated Satureja khuzistanica 显示文摘 | Moghaddam F M Farimani M M Salahvarzi S | 2007 | eCAM2007，4，1： | 1 |
| 4 | Creati - Nine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis显示文摘 | Shamsidini S Darvish - Moghaddam S Abdollahi H | 2006 | East Mediterr Heahh J2006，12，12： | 1 |
| 5 | Visual tracking and recognition using appearance-adaptive models in particle filters显示文摘 | Zhou S K Chellappa R Moghaddam B | 2004 | IEEE Transaction on Image Processing2004，13，11： | 1 |
| 6 | Development of bile duct be- zoars following cholecystectomy caused by choledochoduodenal fistula formation : A case report显示文摘 | Moghaddam JA Amini M Adibnejad S | 2006 | BMC gastroentero12006，6，1： | 1 |
| 7 | Visual Tracking and Recognition Using Appearance Adaptive Models in Particle Filters显示文摘 | ZHOU S K CHELLAPPA R MOGHADDAM B | 2004 | IEEE Trans on Image Processing2004，13，11： | 1 |
| 8 | Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of acluaporin-4 in rat brain显示文摘 | Nielsen S Nagelhus EA Amiry- Moghaddam M | 1997 | J Neurosci1997，17，1： | 1 |
| 9 | Measuring glycaemic responses:duplicate fasting samples or duplicate measures of one fasting sample?显示文摘 | WOLEVER T M S IP B MOGHADDAM E | 2006 | Br J Nutr2006，96，： | 1 |
| 10 | Assessment of biofilm cell removal and killing and biocide efficacy using the microtiterplatetest显示文摘 | Shakeri S Kermanshahi R K Moghaddam E G | 2007 | Biofouling2007，23，2： | 1 |
| 11 | Percutoneous nephrolithotomy of patients with staghom stone and incidental purulent fluid suggestive of infection显示文摘 | Hosseini M M Basiri A Moghaddam S M | 2007 | J Endourol2007，21，2： | 1 |
| 12 | Complete supine percutaneous nephrolithotripsy comparison with the prone standard technique显示文摘 | Falahatkar S Moghaddam AA Salehi M | 2008 | J Endourol2008，22，11： | 1 |
| 13 | Refinement of lung nodule candidates based on local geometric shape analysis andLaplacian of Gaussian kernels显示文摘 | Saien S Pilevar A H Moghaddam H A | 2014 | Computers in Biology and Medicine2014，54，1： | 1 |
| 14 | Visual tracking and recognition using appearance-adaptive models in par- ticle filters 显示文摘 | Zhou S K Chellappa R Moghaddam B | 2004 | Image Processing IEEE Transactions on2004，13，11： | 1 |
| 15 | Chemical constituents of dichloromethane extract of cultivated Satureja khuzistanica 显示文摘 | Moghaddam FM Farimani MM Salabvarzi S | 2007 | Evid-Based CompIAlt2007，4，： | 1 |
| 16 | Visual tracking andrecognition using appearance-adaptive models in particlefilters显示文摘 | Zhou S K Chellappa R Moghaddam B | 2004 | IEEE Transactions on Image Processing2004，13，11： | 1 |
| 17 | Electrochemical properties of LiMn2O4 cathode material doped with an actinide 显示文摘 | EFTEKHARI A MOGHADDAM A B MEHRAN S H | 2006 | J Alloys and Compounds2006，424，1： | 1 |
| 18 | Are the serum biomarkers pepsinogen I and II good predictors for the detection of subjects with atrophic gastritis in areas that have different gastric cancer incidence?显示文摘 | Mohamadkhani A Darvish Moghaddam S Salmanroghani H | 2013 | Arch Iran Med2013，16，4： | 1 |
| 19 | Time course of 25(OH)D3 vitamin D3 as well as PTH(parathyroid hormone)dur-ing fracture healing of patients with normal and low bone mineraldensity(BMD)显示文摘 | Wofl C Englert S Moghaddam AA | 2013 | BMC Musculoskelet Disord2013，14，： | 1 |
| 20 | Forest Vari- able Estimation from Fusion of SAR and Multispec- tral Optical Data显示文摘 | Moghaddam M Dungan J L Acker S | | 0，，10： | 1 |
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