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| 1 | Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity显示文摘Hepatitis B virus(HBV)chronically infects more than350 million people worldwide.HBV causes acute and chronic hepatitis,and is one of the major causes of cirrhosis and hepatocellular carcinoma.There exist complex interactions between HBV and the immune system including adaptive and innate immunity.Tolllike receptors(TLRs)and TLR-signaling pathways are important parts of the innate immune response in HBV infections.It is well known that TLR-ligands could suppress HBV replication and that TLRs play important roles in anti-viral defense.Previous immunological studies demonstrated that HBV e antigen(HBeAg)is more efficient at eliciting T-cell tolerance,including production of specific cytokines IL-2 and interferon gamma,than HBV core antigen.HBeAg downregulates cytokine production in hepatocytes by the inhibition of MAPK or NF-κB activation through the interaction with receptor-interacting serine/threonine protein kinase.MicroRNAs(miRNAs)are also able to regulate various biological processes such as the innate immune response.When the expressions of approximately 1000 miRNAs were compared between human hepatoma cells HepG2 and HepG2.2.15,which could produce HBV virion that infects chimpanzees,using real-time RT-PCR,we observed several different expression levels in miRNAs related to TLRs.Although we and others have shown that HBV modulates the host immune response,several of the miRNAs seem to be involved in the TLR signaling pathways.The possibility that alteration of these miRNAs during HBV infection might play a critical role in innate immunity against HBV infection should be considered.This article is intended to comprehensively review the association between HBV and innate immunity,and to discuss the role of miRNAs in the innate immune response to HBV infection. | Xia Jiang Tatsuo Kanda Shuang Wu Masato Nakamura Tatsuo Miyamura Shingo Nakamoto Arup Banerjee Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，23： | 6 |
| 2 | Study on Targeting and in vitro Anti-oxidation of Baicalin Solid Lipid Nanoparticles显示文摘Objective To prepare liver-targeted baicalin solid lipid nanoparticles(BSLNs) and to study their in vitro anti-oxidative activity.Methods BSLNs were prepared by emulsification ultrasonic dispersion method and characterized by transmission electron microscopy and laser particle size distribution;The tissue in vivo distribution was detected by pharmacokinetics;In vitro anti-superoxide dismutase(SOD) activity and reduction capacity of BSLNs were determined;The ability of removing hydroxyl radical was determined by phenanthroline-Fe2+ oxidation.Results The best prescription was baicalin-soybean lecithin-glyceryl monostearate-poloxamer 188(1:5:15:30);The encapsulation efficiency and drug loading were 84.7% and 5.65%,respectively,mean size of particles was(68.6 ± 8) nm,Zeta potential was 22.13 mV;The in vitro anti-oxidant results showed that BSLNs had a significant inhibitory effect on SOD and a strong reducing capacity as well as a removing hydroxide radical ability.The targeting rate of BSLNs was 6.931 for liver.Conclusion The results demonstrate that BSLNs could enhance the liver targeting ability and in vitro anti-oxidative activity significantly. | MIYAMURA Mitsuhiko YOKOTA Junko YOSHIOKA Saburo | 2012 | Chinese Herbal Medicines2012，4，4： | 4 |
| 3 | 在有固执地正常的丙氨酸 aminotransferase 的丙肝病毒病人的 IL-28B 多型性和治疗反应显示文摘 AIM:To examine the association between the interleukin 28B(IL-28B)genotype and treatment response in hepatitis C virus(HCV)-infected patients with persistently normal alanine aminotransferase(PNALT).METHODS:We compared the treatment response of HCV-infected patients with PNALT to that of patients with non-PNALT.Between February 2010 and April2013,278 patients infected with HCV were enrolled in this study.All of the patients were treated with peginterferon-alpha 2a or 2b plus ribavirin.In addition,180μg of peginterferon alpha-2a or 1.5μg/kg peginterferon alpha-2b per week plus weight-based ribavirin(600-1000 mg/d)were typically administered for 24 wk to HCV genotype 2-infected patients or for 48-72 wk to HCV genotype 1-infected patients.In all of the patients,the IL-28B rs8099917 genotype was determined using a TaqMan single-nucleotide polymorphism assay.HCV RNA was measured using the COBAS TaqMan HCV test.RESULTS:Female patients were dominant in the PNALT group(P<0.0001).Among 72 HCV genotype 1-infected patients with PNALT,the early virologic response(EVR)rates(P<0.01)and the sustained virologic response(SVR)rates(P<0.01)were higher in patients with the IL-28B TT genotype than in those with the IL-28B TG/GG genotype.In HCV genotype 1-infected patients with PNALT,multivariate logistic-regression analysis showed that SVR was independently predicted by the IL-28B rs8099917 TT type(P<0.05)and having an EVR(P<0.01).The IL-28B rs8099917 TT genotype strongly correlated with treatment response in HCV genotype 1-infected Asian patients with PNALT.CONCLUSION:The IL-28B genotype may be useful for selecting HCV genotype 1-infected patients with PNALT who should receive interferon-based treatment. | Tatsuo Miyamura Tatsuo Kanda Masato Nakamura Xia Jiang Shuang Wu Shingo Nakamoto Shigeru Mikami Nobuo Takada Fumio Imazeki Osamu Yokosuka | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 4 | Inherited adrenocorticotropin-independent maeronodular adrenal hyperplasia with abnormal cortisol secretion by vasopressin and catecholamines:detection of the aberrant hormone receptors on adrenal gland显示文摘 | Miyamura N Taguchi T Murata Y | 2002 | Endocrine2002，19，： | 1 |
| 5 | A case of ACTH-independent macronodular adrenal hyperplasia:simultaneous expres-sion of several aberrant hormone receptors in the adrenal gland显示文摘 | Miyamura N Tsutsumi A Senokuchi H | 2003 | Endocr J2003，50，3： | 1 |
| 6 | A novel mutation of the tyrosinase gene causing oculocutaneous albinism type 1 (OCA1) 显示文摘 | NAKAMURA E MIYAMURA Y MATSUNAGA J | 2002 | J Dermatol Sci2002，28，2： | 1 |
| 7 | Molecular bases of congenital hypopigmentary disorders in humans and oculocutaneous albinism 1 in Japan显示文摘 | TOMITA Y MIYAMURA Y KONO M | 2000 | Pigment Cell Res2000，13，： | 1 |
| 8 | Inactivation of chloramphenicol by chloramphenicolresistant bacteria显示文摘 | Miyamura S | 1964 | J Pharm Sci1964，53，： | 1 |
| 9 | A clinical study of five cases demonstrating relapsing polychondritis 显示文摘 | Minami R Miyamura T Nakamura M | 2009 | Nihon Rinsho Meneki Gakkai Kaishi2009，32，4： | 1 |
| 10 | The firstepidemic of acute hemorrhagic conjunctivitis due to acoxsackievirus A24variant in Okinawa,Japan,in 1985-1986显示文摘 | Miyamura K Yamashita K Takeda N | 1988 | Jpn Med Sci Biol1988，41，4： | 1 |
| 11 | Inherited adrenocortico-tropin-independent macronodular adrenal hyperplasia with abnormalcortisol secretion by vasopressin and catecholamines:detection of theaberrant hormone receptors on adrenal gland显示文摘 | Miyamura N Taguchi T Murata Y | 2002 | Endocrine2002，19，3： | 1 |
| 12 | The nucleo-tide sequence of 3Cproteinase region of the coxsackievir-us A24variant:comparison of the isolates in Taiwan in1985-1988显示文摘 | Lin K H Takeda N Miyamura K | 1991 | Virus Genes1991，5，2： | 1 |
| 13 | Blockade of interleukin-6 receptor suppresses inflammatory reaction and facilitates functional re- covery following olfactory system injury 显示文摘 | Kobayashi M Tamari K Miyamura T | 2013 | Neurosci Res2013，76，3： | 1 |
| 14 | Properties of glycyrrhizin in Kampo extracts including licorice root and changes in the blood concentration of glycyrrhetic acid after oral administration of Kampo extracts 显示文摘 | Miyamura M Ono M Kyotani S | 1996 | Yakugaku Zasshi1996，116，3： | 1 |
| 15 | Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71 显示文摘 | Nagata N Shimizu H Ami Y Tano Y Harashima A Suzaki Y Sato Y Miyamura T Sata T Iwasaki T | 2002 | J Med Virol2002，67，2： | 1 |
| 16 | Total circular annuloplasty with absorbable suture for the repair of left atrioventricular valve regurgitation in atrioventricular septaldetect显示文摘 | Miyamura H Eguehi S Watanabe H | 1994 | J Thorac Cardiovasc Surg1994，107，6： | 1 |
| 17 | Vitamin D receptor gene polymorphism and bone mineral density in healthy Japanese women显示文摘 | Miyamura T Lijima S | 1994 | Lancet1994，344，： | 1 |
| 18 | Element-free analysis of shell and spatial structures 显示文摘 | Noguchi H Kawashima T Miyamura T | 2000 | International Journal for Numerical Methods in Engineering2000，47，： | 1 |
| 19 | Some Factors Affecting the Cycle Lives of LaNi5-based Alloy Electrodes of Hydrogen Batteries显示文摘 | Sakai T Qguro K Miyamura H | 1990 | J Less-Common Met1990，161，： | 1 |
| 20 | A case of Takayasurs arteritis associated with human leukocyte an- tigen A24 and B52 following resolution of ulcerative coli- tis and subacute thyroiditis显示文摘 | Horai Y Miyamura T Shimada K | 2011 | Intern Med2011，50，15： | 1 |
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