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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | STM and STS investigations of Ce-doped TiO_2 nanoparticles显示文摘Ce-doped titanium oxide nanoparticles were investigated in the paper. The surface structures of undoped and Ce-doped TiO2 nanoparticles were observed by scanning tunneling microscopy (STM). The experimental results of scan-ning tunneling spectroscopy (STS) show that the surface electronic structures of TiO2 nanoparticles are modified by intro-ducing new electronic states in the surface band gap through cerium ion doping. The results are discussed in terms of the in-fluence of doping concentration on the surface band gap of TiO2. | HOU Tinghong MAO Jian ZHU Xiaodong TU Mingjing | 2006 | Rare Metals2006，25，4： | 4 |
| 3 | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system显示文摘Using a pyrosequencing-based custom-made sequencer BIGIS-4, we sequenced a Gram-negative bacterium Glaciecola mesophila sp. nov. (Gmn) isolated from marine invertebrate specimens. We generated 152043 sequencing reads with a mean high-quality length of 406 bp, and assembled them using the BIGIS-4 post-processing module. No systematic low-quality data was detected beyond expected homopolymer-derived errors. The assembled Gmn genome is 5144318 bp in length and harbors 4303 annotated genes. A large number of metabolic genes correspond to various nutrients from surface marine invertebrates. Its abundant cold-tolerant and cellular signaling and related genes reveal a fundamental adaptation to low-temperature marine environment. | YUAN LiNa REN LuFeng LI YunTao HAN WeiJing YU Yong CHU YaNan LIU GuiMing YU Dan TENG MingJing WANG Liang WANG XuMin ZHOU XiaoGuang YU YuDe YU Jun | 2011 | Science China(Life Sciences)2011，54，9： | 4 |
| 4 | Numerical determination for optimal location of sub-track asphalt layer in high-speed rails显示文摘Well-graded asphalt mix with the merits of high sound absorption, low water permeability, excellent strength, and easy construction is an important option for high-speed railway substructures. On the basis of finite element method, a model with conventional ballasted trackbed (T0) and four ballasted trackbeds models with different positions of asphalt layer were analyzed, in which 15 cm thick asphalt layer was used to replace the different sub-track layers, the bottom and the top of upper subgrade and of ballasted trackbed, named as T1 , T2 , T3 , and T4 , respectively. The results showed that the range of peak vertical accelerations on the top of subgrade surface of T2 and T4 were smaller than T1 and T3 ; T1 and T2 perform better in decreasing the maximum vertical deformation of subgrade than T3 and T4 ; the maximum transversal tensile strain of T4 is almost twice than the other three. The trackbed bears more stress when the asphalt layer is located at the lower part of railway trackbed. | Mingjing Fang Sergio Fernández Cerdas Yanjun Qiu | 2013 | Journal of Modern Transportation2013，21，2： | 4 |
| 5 | Strain localization analyses of idealized sands in biaxial tests by distinct element method显示文摘This paper presents a numerical investigation on the strain localization of an idealized sand in biaxial compression tests using the distinct element method(DEM).In addition to the dilatancy and material frictional angle,the principal stress field,and distributions of void ratio,particle velocity,and the averaged pure rotation rate(APR)in the DEM specimen are examined to illustrate the link between microscopic and macroscopic variables in the case of strain localization.The study shows that strain localization of the granular material in the tests proceeds with localizations of void ratio,strain and APR,and distortions of stress field and force chains.In addition,both thickness and inclination of the shear band change with the increasing of axial swain,with the former valued around 10-14 times of mean grain diameter and the later overall described by the Mohr-Coulomb theory. | Mingjing JIANG Hehua ZHU Xiumei LI | 2010 | Frontiers of Structural and Civil Engineering2010，4，2： | 4 |
| 6 | Comparative analysis on dynamic behavior of two HMA railway substructures显示文摘A numerical analysis using a finite element program was performed on three structures:hot mix asphalt(HMA) reinforced trackbed(RACS-1),HMA directly supported trackbed(RACS-2),and traditional Portland Cement Concrete(PCC) slab track(SlabTrack).Although the comprehensive dynamic responses of RACS-1 were similar with SlabTrack,HMA layer can positively affect the stress distributions.In particular,the horizontal stresses indicate that the resilience of RACS-1 was improved relative to SlabTrack.In addition,HMA reinforced substructure has the capacity to recover the residual vertical deformation.The effective depth for weakening dynamic loadings is mainly from 0 to 2 m,this being especially true at 0.5 m.The results from the analysis show that HMA is a suitable material for the railway substructure to enhance resilient performance,improve the stress distribution,weaken dynamic loading,and lower the vibration,especially at the effective depth of 2 m.The HMA constructed at the top of the stone subbase layer allows the vertical modulus a smooth transition.In terms of the comprehensive dynamic behaviors,RACS-1 is better than SlabTrack,while the results for RACS-2 are inconclusive and require further research. | Mingjing FANG Yanjun QIU Jerry G. ROSE Randy C. WEST Changfa AI | 2011 | Journal of Modern Transportation2011，19，1： | 3 |
| 7 | Precast system and assembly connection of cement concrete slabs for road pavement: A review显示文摘Prefabricated pavement is increasingly applied worldwide due to the rapid construction on-site.This paper presents a state-of-the-art review of the precast systems and assembly connection of concrete slabs,as well as the precast pavement features.The previous research indicates that:(1)both super-slab and Michigan systems are recommended with the satisfied road performance close to the cast-in-place;(2)flexible base material is suggested for the fabricated pavement for the satisfied leveling and stress distribution;(3)to prevent the voiding phenomenon of the fabricated pavement,the sand cushion course,dry mixed mortar or self-leveling mortar,and other flowable materials could be used for the secondary leveling of the base after the pavement splicing;(4)two-direction dowel bars are recommended for slab connections of the fabricated pavement,which helps to improve the load transfer capacity of the joints and enhance the durability of the fabricated pavement structure;(5)the sealing treatment of precast slab joints needs strengthening to reduce the impact of surface runoff on the base course;(6)the further research focuses are designing with functional,composite,mechanized,intelligent,lightweight,and flexible pavement slabs.Besides,pavement mechanical properties induced by temperature overlapping traffic loads need to be revealed. | Mingjing Fang Ran Zhou Wenhui Ke Bo Tian Yubin Zhang Jianjun Liu | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，2： | 3 |
| 8 | Theoretical analysis on ground vibration attenuation using sub-track asphalt layer in high-speed rails显示文摘Using a finite element method(FEM) program,a Portland cement concrete slab trackbed(So),and a subtrack asphalt roadbed(RAC-S) were modeled under highspeed train loads to analyze their responses to ground vibration attenuation,by considering 10,15,20,25,and 30 thick sub-track asphalt layer replaced on the top of the upper subgrade.FEM results show that the vibration amplitude of RAC-S is at least three times lower than the vibration for S_0.The maximum vibration amplitude of RAC-S is linearly increased with train speed.The vertical acceleration is found to be reduced by more than 10%when the asphalt layer thickness is increased from 10 to20 cm.However,the reduction in vertical acceleration is only about 1%when the thickness of the asphalt layer changes from 20 to 30 cm.The vibration level is slightly lower if the asphalt layer has higher resilient modulus in the seasons of autumn or winter.This theoretical analysis indicates that a railway substructure that consists of a10-20 cm thick high modulus asphalt layer located at the top of trackbed shows a good performance in ground vibration control for high-speed rails. | Mingjing Fang Sergio Fernández Cerdas | 2015 | Journal of Modern Transportation2015，23，3： | 2 |
| 9 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 10 | The giant magnetocaloric effect in Gd_(5)Si_(2)Ge_(2)with low purity gadolinium显示文摘The giant magnetocaloric effect Gd5Si2Ge2 alloy was prepared with 99wt% low purity commercial Gd. Pow-der XRD and magnetic measurements showed that the Gd5Si2Ge2 alloy annealed at 1200℃ for 1 h had a significant magnetic- crystallographic first order phase transition at about 270 K. The maximal magnetic entropy change is 17.55 J·kg?1·K?1 under a magnetic field change of 0―5 T. The distinct increase of magnetic entropy change belongs to the first-order phase transition from the orthorhombic Gd5Si4-type to the monoclinic Gd5Si2Ge2-type after high temperature heat-treatment. | ZHANG Tiebang CHEN Yungui FU Hao TENG Baohua TANG Yongbai TU Mingjing | 2005 | Chinese Science Bulletin2005，50，16： | 2 |
| 11 | DEM investigation of rock/bolt mechanical behaviour in pull-out tests显示文摘Rock bolt anchorage performance is crucial for tunnel support safety.We investigate the mechanical behaviour of reinforced rock and the bolts that reinforce it from the micro-scale to the macro-scale.Bolt pull-out tests were performed on soft rock using the distinct element method,in which a new contact model that considers bond size,is employed to constrain the main rock mechanical behaviour.The minimum sample width and height values for which the boundary effect can be neglected are first proposed through numerous tests on the influence of sample size on peak load and bond breakage.The influence of sample width is substantially greater than that of sample height.We then select an appropriate sample size to study the influence of bolt embedment length and confining pressure on the mechanical behaviours of the rock and bolt.The results show that increased rock bolt embedment length and confining pressure can increase the peak load;however,the bolt length effect is limited when exceeding the critical anchorage length.In cases without confining pressure,bond breakage occurs in the rock around the grout-rock interface and the breakage zone is rectangular,whereas in cases under confining pressure,the breakage zone presents an inverted cone shape.We use our results to discuss the influence of bond strength at the bolt-grout interface on the peak load and failure mode.The failure mode changes gradually from complex failure to single failure along the bolt-grout interface with decreasing interfacial bond strength. | Na Che Huaning Wang Mingjing Jiang | 2020 | Particuology2020，18，5： | 2 |
| 12 | Effects of imazethapyr spraying on plant growth and leaf surface microbial communities in Arabidopsis thaliana显示文摘Imazethapyr (IM) is an acetolactate synthase (ALS)-inhibiting herbicide that has been widely used in recent years.However,IM spraying can lead to the accumulation of herbicide residues in leaves.Here,we determined the effects of IM spraying on the plant growth and leaf surface microbial communities of Arabidopsis thaliana after 7 and 14 days of exposure.The results suggested that IM spraying inhibited plant growth.Fresh weight decreased to 48% and 26% of the control value after 7 and 14 days,respectively,of 0.035 kg/ha IM exposure.In addition,anthocyanin content increased 9.2-fold and 37.2-fold relative to the control content after 7 and 14 days of treatment,respectively.Furthermore,IM spraying destroyed the cell structures of the leaves,as evidenced by increases in the number of starch granules and the stomatal closure rate.Reductions in photosynthetic efficiency and antioxidant enzyme activity were observed after IM spraying,especially after 14 days of exposure.The diversity and evenness of the leaf microbiota were not affected by IM treatment,but the composition of community structure at the genus level was altered by IM spraying.Imazethapyr application increased the abundance of Pseudomonas,a genus that includes species pathogenic to plants and humans,indicating that IM potentially increased the abundance of pathogenic bacteria on leaves.Our findings increase our understanding of the relationships between herbicide application and the microbial community structures on plant leaves,and they provide a new perspective for studying the ecological safety of herbicide usage. | Wanyue Liu Mingjing Ke Zhenyan Zhang Tao Lu Youchao Zhu Yan Li Xiangliang Pan Haifeng Qian | 2019 | Journal of Environmental Sciences2019，31，11： | 2 |
| 13 | 3D Mineral Prospectivity Mapping Based on Deep Metallogenic Prediction Theory:A Case Study of the Lala Copper Mine,Sichuan,China显示文摘With the decrease in surface and shallow ore deposits,mineral exploration has focused on deeply buried ore bodies,and large-scale metallogenic prediction presents new opportunities and challenges.This paper adopts the predictive thinking method in this era of big data combined with specific research on the special exploration and exploitation of deep-earth resources.Four basic theoretical models of large-scale deep mineralization prediction and evaluation are explored:mineral prediction geological model theory,multidisciplinary information correlation theory,mineral regional trend analysis theory,and mineral prediction geological differentiation theory.The main workflow of large-scale deep resource prediction in the digital and information age is summarized,including construction of ore prospecting models of metallogenic systems,multiscale 3 D geological modeling,and 3 D quantitative prediction of deep resources.Taking the Lala copper mine in Sichuan Province as an example,this paper carries out deep 3 D quantitative prediction of mineral resources and makes a positive contribution to the future prediction and evaluation of mineral resources. | Keyan Xiao Jie Xiang Mingjing Fan Yang Xu | 2021 | Journal of Earth Science2021，32，2： | 2 |
| 14 | Preparation of Spherical Microfine Silicon Powder显示文摘Under certain conditions of proper temperature and pH value, sodium silicate was hydrolyzed in liquid ammonia chloride, and spherical microfine SiO2 powder in micrometer-size was prepared. In this experiment, the relationship between needed time and proper pH value, temperature, density of the solution, and its current capacity were found .The optimum conditions are pH 8.5, 70 ℃, and the concentration of sodium silicate is 0.6 mol/L for the density of the solution. The structure of spherical microfi ne silicon was charactetized by SEM and XRD. | SHENG Yong ZOU Jun LI Bing TU Mingjing | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 2 |
| 15 | A novel specimen preparation method for TJ-1 lunar soil simulant in hollow cylinder apparatus显示文摘Conventional methods for hollow cylinder apparatus (HCA) specimen preparation are not applicable for TJ-1 lunar soil simulant due to its wide particle size distribution. A novel method to prepare uniform TJ-1 specimen for HCA tests is put forward. The method is a combination of the multi-layering dry-rodding method and a new under-compaction criterion in the multi-layer with under-compaction method (UCM). In the novel method, the specimen is prepared with 5 layers by dry-rodding and the UCM is used to determine the height after each layer is compacted. The density uniformity of specimen is evaluated by the freezing method to find out the best under-compaction criterion. Two HCA specimens with the same target density are prepared by the novel method and examined in the tests of pure rotation of the principal stresses. Their conformable mechanical behaviors ascertain the effectiveness of the method to produce uniform and reproducible HCA specimens. Four groups of HCA tests are carried out to investigate the anisotropic and non-coaxial behaviors of TJ-1 lunar soil simulant. The results indicate that the principal stress direction, the deviator stress ratio, the stress level and the coefficient of the intermediate principal stress significantly influence the strength and deformation properties of TJ-1 lunar soil simulant. | Mingjing Jiang Zhifu Shen Liqing Li Jiaxing Su | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，4： | 2 |
| 16 | Preparation of isotropic Sm_2Fe_(17)N_x magnetic powders and their bonded magnets显示文摘The isotropic Sm2Fe17Nx magnetic powders were prepared by Hydrogenation-Disproportion-Desorption-Recombination (HDDR) process. The phase and microstructure evolutionary process of Sm-Fe alloy during the solidification, homogenization, HDDR and nitration processes were investigated by means of XRD, SEM, EDX and AFM. The results show that the homogeneous Sm2Fe17 alloy was successfully obtained and the impurity phases and residual stress were well removed by heated at 1050 ℃ for 24 h. When heated at 800 ℃ for 1h in H2 of 0.1 MPa, the alloy turns into SmHx and α-Fe with plenty of nanocrystals. After vacuumized at 800 ℃ for 2 h the alloy recombines into Sm2Fe17 with a crystal grain size of about 85 nm. The lattice constant of the alloy increases and the expanding of the crystal cell reaches 6.28% after nitrified at 500 ℃ for 5 h. The magnetic property of isotropic bonded Sm2Fe17Nx magnets is Br=0.6704 T, Hcj=1015 kA·m-1, (BH)max=73.7 kJ·m-3 with a density of 6.04 g·cm-3. | YE Jinwen LIU Ying LI Meng SONG Dayu GAO Shengji TU Mingjing | 2006 | Rare Metals2006，25，z1： | 2 |
| 17 | Wood waste biochar promoted anaerobic digestion of food waste:focusing on the characteristics of biochar and microbial community analysis显示文摘Anaerobic digestion(AD)has been considered as a promising technique for food waste(FW)recycling.However,the accumulation of volatile fatty acids(VFAs)restricts the stability of anaerobic reactors.The present study investigated the use of biochar produced at different conditions(750℃-30 min,750℃-60 min,750℃-120 min,550℃-60 min,650℃-60 min,850℃-60 min,950℃-60 min)for enhancing the AD of FW.Batch experiments showed that all the biochar increased the methane production rates and biochar obtained at 750℃-60 min resulted in the highest enhance-ment by 21.5%.It was further showed surface oxygen-containing functional groups and graphitization degree of biochar were the critical factors for improving methane production.Microbial analysis showed that biochar addi-tion formed different microbial communities,and Methanosaeta,Romboutsia,and norank_f_Anaerolineaceae were enriched,which might be correlated with direct interspecies electron transfer(DIET).This research showed biochar could enhance the AD of FW and also revealed the main characteristics of biochar relating with the enhancement of AD. | Chao Zhang Rui Yang Meichen Sun Shicheng Zhang Mingjing He Daniel C.W.Tsang Gang Luo | 2022 | Biochar2022，4，1： | 2 |
| 18 | Gas sensors based on TiO_(2) nanostructured materials for the detection of hazardous gases: A review显示文摘Hazardous gases have been strongly associated with being a detriment to human life within the environment The development of a reliable gas sensor with high response and selectivity is of great signifcance for detecting different hazardous gases.TiO_(2) nanomaterials are promising candidates with great potential and excellent per-formance in gas sensor applications,such as hydrogen,acetone,ammonia,and ethanol detection.This review begins with a detailed discussion of the di ferent dimensional morphologies of TiO_(2),whitch affect the gas sensing performance of TiO_(2) sensors.The diverse morphologies of TiO_(2) can easily be tuned by regulating the manufacturing conditions.Meanwhile,they exhibit unique characteristics for detecting gases,including large specific suface area,superior elecron tr ansport rates,extraordinary pemmeability,and active reaction sites,which offer new opportunities to improve the gas sensing properties.In addition,a variety of efforts have been made to functional TiO_(2) nanomaterials to further enhance sensing properties,including TiO_(2)-based composites and light-assisted gas sensors.The enhanced gas sensing mechanisms of multi-component composite nano-materials based on TiO_(2) include loaded noble metals,doped elements,constructed heterojunctions,and com-pounded with other functional materials.Finally,several studies have been summarized to demonstate the compar ative sensing properties of TiO_(2)-based gas sensors. | Xu Tian Xiuxiu Cui Tingrun Lai Jie Ren Zhichao Yang Mingjing Xiao Bingsen Wang Xuechun Xiao Yude Wang | 2021 | Nano Materials Science2021，3，4： | 1 |
| 19 | CO2-assisted template synthesis of porous hollow bi-phase γ-/α-Fe2O3 nanoparticles with high sensor property 显示文摘 | MINGJ WU Y Q WANG LY | 2011 | Journal of materials chemistry2011，21，17： | 1 |
| 20 | Distinct element method analyses of idealized bonded-granulate cut slope显示文摘 | Mingjing Jiang Akira Murakami | 2012 | Granular Matter2012，，3： | 1 |
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