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| 1 | Protic vs aprotic ionic liquid for CO2 fixation:A simulation study显示文摘The cycloaddition of CO2 with epoxides catalyzed by ionic liquids(ILs)has been a widely ongoing studied hot topic over the years.Recent experimental research has shown that the protic ionic liquids(PILs)behave stronger hydrogen proton donating ability than aprotic ionic liquids(APILs),and can effectively catalyze the cycloaddition of CO2.Unfortunately,the mechanistic explanation remains primarily unraveled.Herein,a detailed simulation study on the cycloaddition reaction catalyzed by PIL([HDBU][Mim])in comparison with APIL([MeDBU][Mim])re-action catalysts was conducted,including the three-step route(ring-opening of PO(propylene oxide),insertion of CO2 and ring-closure of propylene carbonate(PC))and two-step route(simultaneously ring-opening of PO and addition of CO2,and then ring-closure of PC).Based on the activation energy barrier of the rate-determining step,PIL preferentially activates PO as the optimal route for the reaction with the energy barrier of 23.2 kcal mol-1,while that of APIL is 31.2 kcal mol-1.The role of[HDBU]+in the reaction was also explored and found that the direct formation of intermolecular hydrogen bond(H-bond)between[HDBU]+and the reactants(PO+CO2)was unfavorable for the reaction,while the cooperation with the anion[Mim]-to assist indirectly was more conducive.To fully consider the reaction microenvironment of ILs,ONIOM calculation was used to study the solvent effect.At last,the above conclusions were further verified by the analysis of intermediates with charge,non-covalent interaction(NCI),and atoms in molecules(AIM)methods.The computational findings show that ILs studied in this work have dual functions of catalyst and solvent,enabling a microscopic understanding of the ILs catalyst for CO2 utilization as well as providing guidance for the rational design of more efficient ILs-based catalysts. | Wenzhong Sun Meichen Wang Yaqin Zhang Weilu Ding Feng Huo Li Wei Hongyan He | 2020 | Green Energy & Environment2020，5，2： | 4 |
| 2 | Wood waste biochar promoted anaerobic digestion of food waste:focusing on the characteristics of biochar and microbial community analysis显示文摘Anaerobic digestion(AD)has been considered as a promising technique for food waste(FW)recycling.However,the accumulation of volatile fatty acids(VFAs)restricts the stability of anaerobic reactors.The present study investigated the use of biochar produced at different conditions(750℃-30 min,750℃-60 min,750℃-120 min,550℃-60 min,650℃-60 min,850℃-60 min,950℃-60 min)for enhancing the AD of FW.Batch experiments showed that all the biochar increased the methane production rates and biochar obtained at 750℃-60 min resulted in the highest enhance-ment by 21.5%.It was further showed surface oxygen-containing functional groups and graphitization degree of biochar were the critical factors for improving methane production.Microbial analysis showed that biochar addi-tion formed different microbial communities,and Methanosaeta,Romboutsia,and norank_f_Anaerolineaceae were enriched,which might be correlated with direct interspecies electron transfer(DIET).This research showed biochar could enhance the AD of FW and also revealed the main characteristics of biochar relating with the enhancement of AD. | Chao Zhang Rui Yang Meichen Sun Shicheng Zhang Mingjing He Daniel C.W.Tsang Gang Luo | 2022 | Biochar2022，4，1： | 2 |
| 3 | Sealing reliability modeling of aviation seal based on interval uncertainty method and multidimensional response surface显示文摘Many variables affect the sealing performance, and their distribution characteristics are difficult to obtain with probabilistic methods owing to the high cost involved. Numerous problems in engineering are similar due to the appearance of small-sample parameters. In this study, the sealing reliability of an aviation seal was defined as the research object, and an interval uncertainty method and multidimensional response surface were proposed to calculate the sealing reliability.Based on this, we first analyzed the failure mechanism of the aviation seal and established a leakage rate model. Then, based on the non-probabilistic interval model, an interval uncertainty method was proposed to construct the analytical model. With reference to the limit state equation from the structural reliability theory, the multidimensional response surface was used for fast calculation.Then, we chose the single-cylinder gas steering gear used in aircraft as the case study, its sealing reliability in working and non-working statuses were calculated, and the results were verified with the actual maintenance records. By analyzing the sensitivity of some variables, we can improve the sealing reliability of the aviation seal by improving the surface roughness only if the cost allows.Finally, we consider that the method proposed in this study realizes the application of smallsample uncertainty analysis in reliability analysis, and could provide a feasible way to solve the similar problems in engineering with multidimensional and small-sample parameters. | Baopeng LIAO Bo SUN Yu LI Meichen YAN Yi REN Qiang FENG Dezhen YANG Kun ZHOU | 2019 | Chinese Journal of Aeronautics2019，32，9： | 1 |
| 4 | Boron-doped Graphene as Promising Support for Platinum Catalyst with Superior Activity Towards the Methanol Electro Oxidation Reaction显示文摘 | SUN Yongrong DU Chunyu AN Meichen | 2015 | J Power Sources2015，300，： | 1 |
| 5 | Coculture engineering for efficient production of vanillyl alcohol in Escherichia coli显示文摘Vanillyl alcohol is a precursor of vanillin,which is one of the most widely used flavor compounds.Currently,vanillyl alcohol biosynthesis still encounters the problem of low efficiency.In this study,coculture engineering was adopted to improve production efficiency of vanillyl alcohol in E.coli.First,two pathways were compared for biosynthesis of the immediate precursor 3,4-dihydroxybenzyl alcohol in monocultures,and the 3-dehydroshikimate-derived pathway showed higher efficiency than the 4-hydroxybenzoate-derived pathway.To enhance the efficiency of the last methylation step,two strategies were used,and strengthening S-adenosylmethionine(SAM)regeneration showed positive effect while strengthening SAM biosynthesis showed negative effect.Then,the optimized pathway was assembled in a single cell.However,the biosynthetic efficiency was still low,and was not significantly improved by modular optimization of pathway genes.Thus,coculturing engineering strategy was adopted.At the optimal inoculation ratio,the titer reached 328.9 mg/L.Further,gene aroE was knocked out to reduce cell growth and improve 3,4-DHBA biosynthesis of the upstream strain.As a result,the titer was improved to 559.4 mg/L in shake flasks and to 3.89 g/L in fed-batch fermentation.These are the highest reported titers of vanillyl alcohol so far.This work provides an effective strategy for sustainable production of vanillyl alcohol. | Meichen Yang Hao Meng Xianglai Li Jia Wang Xiaolin Shen Xinxiao Sun Qipeng Yuan | 2022 | aBIOTECH2022，3，4： | 1 |
| 6 | Multifunctional assessment and zoning of crop production system based on set pair analysis-A comparative study of 31 provincial regions in mainland China显示文摘 | Jin Tao Meichen Fu Jingjing Sun | 2013 | Communications in Nonlinear Science and Numerical Simulation2013，19，： | 1 |
| 7 | Incorporation of Escherichia coli heat-labile enterotoxin B subunit into rabies virus particles enhances its immunogenicity in mice and dogs显示文摘Although inactivated vaccines against rabies have the advantage of high safety,effective protection against rabies virus(RABV)infection often requires multiple,high-dose immunization.Incorporating a molecular adjuvant into the viral particles has been found to be a useful strategy to promote the immune effectiveness of inactivated vaccines.In this study,we constructed a recombinant virus,rCVS11-LTB,which chimerically expresses a molecular adjuvant heat-labile enterotoxin B subunit(LTB)protein on the surface of the RABV particles.Immunogenicity in vivo was found to be promoted by rCVS11-LTB through the activation of dendritic cells(DCs).Our results demonstrated that inactivated rCVS11-LTB was able to induce higher levels of virusneutralizing antibodies(VNAs)in both mice and dogs than the parent virus rCVS11,to enhance the cellular immune response and T cell immune memory in mice,and was also able to provide 100%protection in mice from lethal doses of rabies virus,indicating its potential as a safe and effective inactivated rabies vaccine candidate. | Zhiyuan Gong Hailun Li Meichen Qian Yujie Bai Hongli Jin Jingxuan Sun Mengyao Zhang Cuicui Jiao Pei Huang Yuanyuan Li Haili Zhang Hualei Wang | 2023 | Biosafety and Health2023，5，5： | 0 |
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