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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | The treatment of traumatic optic neuropathy显示文摘 | Leonard A Levin Roy W Beck Michael P Joseph Stuart Seiff Raymond Kraker | 1999 | Ophthalmology1999，，7： | 2 |
| 3 | Degradation Mechanisms of Vertical Cavity Surface Emitting Lasers, Quantum Electronics显示文摘 | Michael C Y Robert W H Pierre M P | 1996 | IEEE Journal1996，32，： | 2 |
| 4 | 颈部疼痛的诊断和管理进展显示文摘颈部疼痛带来了相当大的个人和社会经济负担——它是患病率和伤残所致生命年损失前五位的慢性疼痛疾病之一——但是仅获得了背部疼痛研究的一小部分经费。尽管大多数颈部疼痛急性发作后自行消退,但有超过三分之一的患者群在一年多以后仍有轻度症状或疼痛复发,遗传和社会心理因素是症状持续存在的危险因素。将近一半的慢性颈部疼痛患者具有神经性一损伤反应性混合症状或主要为神经性症状。很少有临床研究专门针对颈部疼痛,、肌肉松弛剂和非甾体类抗炙药对急性颈部疼痛有效,临床实践主要依据其他慢性疼痛的研究结果。补充和替代疗法中,证据级别最强的就是运动,稍弱证据支持不同状况下进行按摩、针灸、瑜伽和脊椎推拿。对于神经根型颈椎病和小关节病,弱证据分别支持硬膜外类固醇注射和射频去神经支配治疗。对于大部分患者,手术在短期内比保守治疗更有效,但长期效果相似,手术前进行临床观察是一种合理策略. | Steven P Cohen W Michael Hooten 公磊 | 2018 | 英国医学杂志中文版2018，21，3： | 2 |
| 5 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 6 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 7 | Value and Risks of Expiring Carbon Credits from Afforestation and Reforestation Projects under the CDM显示文摘 | Michael D Bernahard S Jenny L P W | 2005 | Climate Policy2005，5，1： | 1 |
| 8 | Cobalt( Ⅱ ) tetrasulfophthalocyanine on titanium dioxide: a new efficient electron relay for the photocatalytic formation and depletion of hydrogen peroxide in aqueous suspensions显示文摘 | Andrew P Hong Detlef W Bahnemann Michael R Hoffmann | 1987 | J Phys Chem1987，91，8： | 1 |
| 9 | Selenium assimilation and volatilization from selenocyanate-treated Indian Mustard and Muskgrass显示文摘 | Mark P S Pickering I J Michael W | 2002 | Plant Physiol2002，128，： | 1 |
| 10 | Increase glutathione hiosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaecumulas显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
| 11 | Headway on urban streets: observational data and an intervention to decrease tailgating显示文摘 | MICHAEL P G LEEMING F C DWYER W O | 2000 | Transporta- tion Research Part F2000，3，2： | 1 |
| 12 | Does cultural socialization predict multiple bases and foci of commitment?显示文摘 | Michael Clugston Jon P Howell Peter W Dorfman | 2000 | Journal of Management2000，，1： | 1 |
| 13 | Effective product family design using physical programming显示文摘 | Achille Messas Michael P Martinez Timothy W Simpson | 2002 | Engineering Optimization2002，，34： | 1 |
| 14 | Stability of networked control systems显示文摘 | Zhang W Michael S B Stephen M P | 2001 | IEEE Control Systems Magazine2001，21，1： | 1 |
| 15 | Nonin- vasive positive pressure ventilation in subjects with stable COPD 显示文摘 | Bhatt Surya P Peterson Michael W Wilson Jeffrey S | 2013 | Int J Chron Obstruct Pulmon Dis2013，8，： | 1 |
| 16 | Ischemic preconditioning increases iNOS transcript levels in conscious rabbits via a nitric oxide-dependent mechanism 显示文摘 | Keith W Michael P Xian L | 1999 | J Mol Cell Cardiol1999，31，5： | 1 |
| 17 | Experimental studies in the LENS supersonic and hypersonic tunnels for hypervelocity vehicle performance and code validation 显示文摘 | Michael S H Timothy P W Matthew M | 2008 | AIAA2008，2505，： | 1 |
| 18 | Challenging the public stigma of mental illness : a meta - analysis of outcome stud- ies显示文摘 | Corrigan P W Morris S B Michaels P J | 2012 | Psychiatr Serv2012，63，10： | 1 |
| 19 | Meas uring fractional cover and leaf area index in arid ecosystem: Digital camera, radiation transmittance, and laser altimetry methods显示文摘 | Michael A W Gregory P A Ramakrishna R N | 2000 | Remote Sensing of Environment2000，74，： | 1 |
| 20 | Vertical Stiffness of Elastomeric and Lead-Rubber Seismic Isolation Bearings显示文摘 | GORDON P W ANDREW S W MICHAEL C C | 2007 | Journal of Structural Engineering ASCE2007，133，9： | 1 |
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