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| 1 | Peri-nuclear antibodies correlate with survival in Greek primary biliary cirrhosis patients显示文摘AIM:To investigate possible associations of anti-nuclear envelope antibody(ANEA)with disease severity and survival in Greek primary biliary cirrhosis(PBC)patients.METHODS:Serum samples were collected at diagnosis from 147 PBC patients(85%female),who were followed-up for a median 89.5 mo(range 1-240).ANEA were detected with indirect immunofluorescence on 1% formaldehyde fixed Hep2 cells,and anti-gp210 antibodies were detected using an enzyme linked immunosorbent assay.Findings were correlated with clinical data,histology,and survival.RESULTS:ANEA were detected in 69/147(46.9%) patients and 31/147(21%)were also anti-gp210 positive.The ANEA positive patients were at a more advanced histological stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ56.5%/43.5% vs 74.4%/25.6%,P=0.005)compared to the ANEA negative ones.They had a higher antimitochondrial antibodies(AMA)titer(≤1:160/>1:160 50.7%/49.3%vs 71.8%/28.2%,P=0.001)and a lower survival time(91.7 ±50.7 mo vs 101.8±55 mo,P=0.043).Moreover,they had more advanced fibrosis,portal inflammation,interface hepatitis,and proliferation of bile ductules(P =0.008,P=0.008,P=0.019,and P=0.027,respectively).They also died more frequently of hepatic failure and/or hepatocellular carcinoma(P=0.016).ANEA positive,anti-gp210 positive patients had a difference in stage(Ⅰ-Ⅱ/Ⅲ-Ⅳ54.8%/45.2%vs 74.4%/25.6%,P= 0.006),AMA titer(≤1:160/>1:160 51.6%/48.4%vs 71.8%/28.2%,P=0.009),survival(91.1±52.9 mo vs 101.8±55 mo,P=0.009),and Mayo risk score(5.5 ±1.9 vs 5.04±1.3,P=0.04)compared to the ANEA negative patients.ANEA positive,anti-gp210 negative patients had a difference in AMA titer(≤1:160/>1:160 50%/50%vs 71.8%/28.2%,P=0.002),stage(Ⅰ-Ⅱ/Ⅲ -Ⅳ57.9%/42.1%vs 74.4%/25.6%,P=0.033),fibrosis(P=0.009),portal inflammation(P=0.018),interface hepatitis(P=0.032),and proliferation of bile ductules(P=0.031).Anti-gp210 positive patients had a worse Mayo risk score(5.5±1.9 vs 4.9±1.7,P=0.038)than the anti-gp210 negative ones.CONCLUSION:The presence of ANEA and anti-gp210 identifies a subgroup of PBC patients with advanced disease severity and poor prognosis. | Ourania Sfakianaki Meri Koulentaki Maria Tzardi Elena Tsangaridou Panayotis A Theodoropoulos Elias Castanas Elias A Kouroumalis | 2010 | World Journal of Gastroenterology2010，16，39： | 11 |
| 2 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 3 | Android fat ditribution as predictor of severity in acute pancreatitis 显示文摘 | Mery CM Rubio V Duarte - Rojo A | 2002 | Pancreatology2002，2，6： | 1 |
| 4 | Molecular genetic characterization of t he Fennoscandian cervid strain, a new genotypic group (GIO) of Echinococcus grantdosus 显示文摘 | Lavikainen A Lehtinen MJ Meri T | 2003 | Parasitology2003，127，3： | 1 |
| 5 | Accuracy of intraoper- ative pathological examination of SLN in cervical cancer显示文摘 | Martinez A Mery E Filleron T | 2013 | Gynecol Oncol2013，130，3： | 1 |
| 6 | Potent andspecific geneticinterference by doubl estranded RNA in Caenorhabitis elegans显示文摘 | Fire A Xu S Montgo mery MK et a 1 | 1998 | Nature1998，301，6669： | 1 |
| 7 | Co-deposition of clusterin with the complement membrane attack complex in myocardial infarction显示文摘 | Vakeva A Laurila P Meri S | 1993 | Immunology1993，80，： | 1 |
| 8 | Immune evasion of tumor cells using membrane- bound complement regulatory proteins显示文摘 | Gorter A Meri S | 1999 | lmmunol Today1999，20，12： | 1 |
| 9 | Relationship between a his- tory of antecedent cancer and the probability of malignancy for a sol- itary pulmonary nodule显示文摘 | Mery C M Pappas A N Bueno R | 2004 | Chest2004，125，6： | 1 |
| 10 | Natural polymorphism affecting learning and memory in Drosophila显示文摘 | MERY F BELAY A T SO A K | 2007 | Proc Natl Acad Sci USA2007，104，13： | 1 |
| 11 | Human protectin (CD59), an 18,000 - 20,000MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers 显示文摘 | Meri S Morgan BP Davies A | 1990 | Immunology1990，71，1： | 1 |
| 12 | Iron deficiency anemia in the eLderLy:prevaLence and endoscopic evaLuation of the gastrointestinaL tract in out patients显示文摘 | Coban E TimuragaogLu A Merie M | 2003 | Acta HaematoL2003，10，1： | 1 |
| 13 | Follicular growth in vitro: detection of growth differentiation factor 9 (GDFg) and bone morphogenetic protein 15 (BMP15) during in vitro culture of ovine cortical slices显示文摘 | Mery L Lefevre A Benchaib M | 2007 | Mol Reprod Dev2007，74，6： | 1 |
| 14 | Simultaneous fluorometric determination of nalidixic acid and 7- hydroxymethylnalidixic acid by partial least squares cali- bration 显示文摘 | Durin Meris I Muoz de la Pefia A | 1998 | Talanta1998，45，5： | 1 |
| 15 | Molecular genetic characterization of the fen- noscandian cervid strain, a new genotypic group (G10) of Echinococcus granulosus 显示文摘 | LAVIKAINEN A LEHTINEN M J MERI T | 2003 | Parasitolo- gy2003，127，3： | 1 |
| 16 | Methylene blue as a novel electrochemical hybridization indicator 显示文摘 | Erdem A Kerman K Merie B | 2001 | E- lectroanalysis2001，13，3： | 1 |
| 17 | Fine-tuning in Ca^2+ homeostasis underlies progression of cardiomyopathy in myocytes derived from genetically modifled embryonic stem cells显示文摘 | Grey C Mery A Puceat M | 2005 | Hum Mol Genet2005，14，10： | 1 |
| 18 | Importance of hyperthermie intraper itoneal chemotherapy ( HIPEC ) in ovarian cancer 显示文摘 | Ferron G Martinez A Mery E | 2009 | Bull Cancer2009，96，12： | 1 |
| 19 | Immune evasion of tumor cell using membrane-bound complement regulatory proteins显示文摘 | Gorter A Meri S | | 0，，12： | 1 |
| 20 | The importance of combined coronary anglography and renal angiography in patients with hypertension and isehemie heart disease显示文摘 | Helvaci A Aalet K Merie M | 1996 | Ist Tip Faku Metro1996，59，： | 1 |
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