|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Polycystic ovary syndrome and chronic autoimmune thyroiditis显示文摘 | Jussara de Souza Mayrink Novais Cristina Laguna Benetti-Pinto Heraldo Mendes Garmes Rodrigo Menezes Jales Cá ssia Raquel Teatin Juliato | 2014 | Gynecological Endocrinology2014，，1： | 2 |
| 3 | Subclinical hypothyroidism in young women with polycystic ovary syndrome: an analysis of clinical, hormonal, and metabolic parameters显示文摘 | Cristina Laguna Benetti-Pinto Vanessa Ribeiro Santana Berini Piccolo Heraldo Mendes Garmes Cássia Raquel Teatin Juliato | 2012 | Fertility and Sterility2012，，： | 2 |
| 4 | The role of constraints within generalized nonextensive statistics显示文摘 | Tsallis C Mendes R S Plastino A R | 1998 | Physica A:Statistical Mechanics and its Applications1998，261，3： | 1 |
| 5 | The Effect of a Psychosocial Intervention and Quality of Life after Acute Myocardial Infarction: The Enhancing Recovery in Coronary Heart Disease (ENRICHD) Clinical Trial显示文摘 | Mendes de Leon C F Czajkowski S M | 2006 | J Cardiopulm Rehabil2006，26，1： | 1 |
| 6 | Effect of transglutaminaseand carrageenan on restructured fish products containing dietaryfibres 显示文摘 | Cardoso C Mendes R Nunes M L | 2007 | International Journal of Food Science and Technology2007，42，： | 1 |
| 7 | Acclima- tion of Myrtus communis to contrasting Mediterranean light environments effects on structure and chemical composition of foliage and plant water relations 显示文摘 | Mendes M M Gazarini L C Rodrigues M L | 2001 | En- vironmental and Experimental Botany2001，45，2： | 1 |
| 8 | Theinfluence of doublepulse on porosity formation in aluminum GMAW 显示文摘 | Mendes da Silva C L Scotti A | 2006 | Journal of Materials Processing Technology2006，171，： | 1 |
| 9 | Parameter estimation in biochemical pathway: a comparison of global optimization methods显示文摘 | Moles C G Mendes P Banga J R | 2003 | Genome Research2003，13，： | 1 |
| 10 | Pharmacodynamic comparisons of antimicrobials against nosocomial isolates of escherichia coli,klebsiella pneumoniae,acinetobacter baumannii and pseudomonas aeruginosa from the MYSTIC surveillance program:the OPTAMA Program,South America 2002显示文摘 | KIFFER C R MENDES C KUTI J L | 2004 | Diagn Microbiol Infect Dis2004，49，2： | 1 |
| 11 | Development of a healthylow-fat fishsausage containing dietary fibre 显示文摘 | Cardoso C Mendes R Nunes M L | 2008 | InternationalJournal of Food Science andTechnology2008，43，： | 1 |
| 12 | Numerical simulation of reactive transfers in spouted beds at high temperature:application to coal gasification显示文摘 | Mendes A Dollet A Ablitzer C | 2008 | Journal of Analytical and Applied Pyrolysis2008，82，1： | 1 |
| 13 | Rolling - circle amplification of Torque teno virus ( TTV ) complete genomes from human and swine sera and identification of a novel swine TTV genogroup 显示文摘 | NIEL C DINIZ - MENDES L DEVALLE S | 2005 | J Virol2005，86，： | 1 |
| 14 | A genetic algorithm for the resource constrained multi-project scheduling problem显示文摘 | Goncalves J F Mendes J J M Resende M G C | 2008 | European Journal of Operational Research2008，189，3： | 1 |
| 15 | Determination of ancestral proportions in synthetic bovine breeds using commonly employed microsatellite markers显示文摘 | Bicalho H M S C G Pimenta I K P Mendes | 2006 | Genet Mol Res2006，5，3： | 1 |
| 16 | Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development显示文摘 | Robin C Bollerot K Mendes S | 2009 | Cell Stem Cell2009，5，4： | 1 |
| 17 | Effects of the glyphosate-resistance gene and herbicides on soybean: Field trials monitoring biological nitrogen fixation and yield显示文摘 | Hungria M Mendes I C Nakatani A S | 2014 | Field Crops Research2014，158，： | 1 |
| 18 | A hy- brid genetic algorithm for the job shop scheduling problem显示文摘 | Goncalves J F de Magalhaes Mendes J J Resende M G C | 2005 | European Journal of Operational Research2005，167，1： | 1 |
| 19 | Hand-foot syndrome associated with short infusions of combination chemotherapy with gecitabine and vinorelbine显示文摘 | Laack E Mende T Knuffmann C | 2001 | Ann Oncol2001，12，12： | 1 |
| 20 | Harmonic analysis method for traction drives EMI studies 显示文摘 | Iordache M Mendes E Marchand C | 2003 | IEE Proceedings-Electric Power Applications2003，150，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员