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| 1 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 2 | Nature:骨髓微环境发生突变可导致造血干细胞异常显示文摘白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病,来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身。让细胞自身生长更快。相比之下,努南综合征小鼠模型上可以观察到间接的邻近细胞效应,努南综合征是一种能够增加白血病患病风险的遗传紊乱。 | Lei Dong, Wen-Mei Yu, Hong Zheng, Melinda Pauly, Muxiang Zhou Cheng-Kui Qu Mignon L. Loh Silvia T. Bunting Gang Huang Hal E. Broxmeyer David T. Scadden | 2016 | 现代生物医学进展2016，16，35： | 18 |
| 3 | 对中国流域生态补偿的法律思考显示文摘中国流域经济在快速发展的同时给流域的生态环境也带来了巨大的压力,而流域生态补偿正是为了保障流域生态和经济的可持续性发展所采取的有力措施之一。文章解释了生态补偿和流域生态补偿的概念,阐述了对中国流域生态补偿进行法律保护的必要性,剖析了流域生态补偿法律制度的现状,从流域生态补偿的立法原则、法律体系和补偿机制三方面给出了对中国流域生态补偿的立法建议。 | 张艳芳 Melinda E.Taylor | 2013 | 生态经济2013，29，1： | 11 |
| 4 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 5 | A comparative study on the antioxidant activity of methanolic leaf extracts of Ficus religiosa L,Chromolaena odorata(L.) King & Rabinson,Cynodon dactylon(L.) Pers.and Tridax procumbens L.显示文摘Objective:To compare the antioxidative effects of the methanolic leaf extracts of Ficus religiosa (F.religiosa),Chromolaena odorata(C.odorata),Cynodon dactylon(C.dactylon) and Trida,x procumbens(T.procumbens) as well as the contents of antioxidants in the extracts.Methods: Total phenol and total flavanoid contents were measured according to the standard procedures. The total antioxidant capacity was determined using the phosphomolybdenum method.Reducing power was determined by the potassium ferrieyanide reducing method.The free radical scavenging activity was measured by 2,2’-Diphenyl-l-picrylhydrazyl(DPPH) assay.Results: Quantitative phytochemical analysis of total phenol content showed that C.odorata had the highest content of phenolic compounds significantly followed by F.religiosa,T.procumbens and C.dactylon.As for the total flavanoids content,F.religiosa had the highest content,followed by C.odorata,T.procumbens and C.daxtylon.Study on the total antioxidant capacity revealed that F.religiosa,C.dactylon and C.odorata showed higher total antioxidant capacity.T.procumbens showed the lowest capacity.Meanwhile,T.procumbens and C.odorata have the highest reducing power activity followed by F.religiosa and C.dactylon.The results of DPPH radical scavenging activity indicated that T.procumbens induced the largest elevation as the concentration of its extract increased,followed by C.odorata and F.religiosa and C.dactylon.Conclusions:The present study demonstrates the antioxidative capacity of all the four plant species.Of all the plants,C.odorata,a perennial weed plant showed potentially a high antioxidant activity,with higher phenolic and flavonoids contents.The data suggest that C.odorata can be best utilized in developing bioantioxidants. | Melinda Krishanti P Xavier Rathinam Marimuthu Kasi Diwakar Ayyalu Ramanathan Surash Kathiresan Sadasivam Sreeramanan Subramaniam | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 6 |
| 6 | Data-driven reliability analysis of Boeing 787 Dreamliner显示文摘The Boeing 787 Dreamliner,launched in 2011,was presented as a game changer in air travel.With the aim of producing an efficient,mid-size,wide-body plane,Boeing initiated innovations in product and process design,supply chain operation,and risk management.Nevertheless,there were reliability issues from the start,and the plane was grounded by the U.S.Federal Aviation Administration(FAA)in 2013,due to safety problems associated with Li-ion battery fires.This paper chronicles events associated with the aircraft’s initial reliability challenges.The manufacturing,supply chain,and organizational factors that contributed to these problems are assessed based on FAA data.Recommendations and lessons learned are provided for the benefit of engineers and managers who will be engaged in future complex systems development. | Guru PANDIAN Michael PECHT Enrico ZIO Melinda HODKIEWICZ | 2020 | Chinese Journal of Aeronautics2020，33，7： | 6 |
| 7 | Preparation of thalidomide nano-flakes by supercritical antisolvent with enhanced mass transfer显示文摘Thalidomide treats multiple myeloma and protracts life-span of patient, but its bioavailability is limited as it is poorly water soluble. Thalidomide nano-flakes are produced to improve the drug dissolution rate. Two nanoflake production methods are utilized for a comparative study:a supercritical antisolvent (SAS) method and a supercritical antisolvent with enhanced mass transfer (SAS-EM). SAS-EM utilizes ultrasonication to improve dispersion upon injection within the supercritical carbon dioxide. Comparative study of SAS and SAS-EM thalidomide confirmed that the application of ultrasonication improved the micro/nano particles produced by SAS. The effects of ultrasound power on the formation of thalidomide particles are examined. The particle size and morphology were characterized by SEM. The thalidomide nano-flakes produced by SAS-EM were smaller than the particles produced by SAS. Dissolution rates of the produced particles, evaluated by HPLC, demonstrated an increase in the thalidomide dissolution rate for the SAS-EM produced particles. The polymorphs and crystallinity of thalidomide particles (flakes) were observed by FTIR and XRD. In this research, the supercritical processing significantly modified the crystal formation of thalidomide from an original state of a β-polymorph to the amorphous state β-polymorph after supercritical processing. | HeyangJin Melinda Hemingway Ram B. Gupta Fei Xia Yaping Zhao | 2012 | Particuology2012，10，1： | 5 |
| 8 | Malignancies of the Appendix: Beyond Case Series Reports显示文摘 | Marcia L. McGory M.D. Melinda A. Maggard M.D. M.S.H.S. Hakjung Kang M.D. Ph.D. Jessica B. O'Connell M.D. Clifford Y. Ko M.D. M.S. M.S.H.S | 2005 | Diseases of the Colon & Rectum2005，，12： | 5 |
| 9 | A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure显示文摘5q-syndrome is a distinct form of myelodysplastic syndrome(MDS) where a deletion on chromosome 5 is the underlying cause.MDS is characterized by bone marrow failures,including macrocytic anemia.Genetic mapping and studies using various models support the notion that ribosomal protein S14(RPS14) is the candidate gene for the erythroid failure.Targeted disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal proteins.However,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment option.To better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 gene.This model mirrors the anemic phenotype seen in 5q-syndrome.Moreover,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes p53-dependent.Finally,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype. | Jason Ear Jessica Hsueh Melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo Lin | 2016 | Journal of Genetics and Genomics2016，43，5： | 5 |
| 10 | Immunological changes in different patient populations with chronic hepatitis C virus infection显示文摘AIM: To investigate killer inhibitory and activating receptor expression by natural killer(NK), natural killer T-like(NKT-like) and CD8+ T lymphocytes in patients with chronic hepatitis C virus(HCV) infection with elevated and with persistently normal alanine aminotransferase(PNALT).METHODS: The percentage of peripheral blood Treg cells, KIR2DL3, ILT-2, KIR3DL1, CD160, NKG2 D, NKG2 C expressing NK, T and NKT-like cells, cytokine production and NK cytotoxicity were determined by flow cytometry. Twenty-one patients with chronic HCV infection with elevated alanine aminotransferase, 11 HCV carriers with persistently normal alanine aminotransferase and 15 healthy volunteers were enrolled. RESULTS: No significant differences were observed in the percentage of total T, NK or NKT-like cells between study groups. Comparing the activating and inhibitoryreceptor expression by NK cells obtained from HCV carriers with PNALT and chronic HCV hepatitis patients with elevated alanine aminotransferase, NKG2 D activating receptor expression was the only receptor showing a significant difference. NKG2 D expression of NK cells was significantly lower in patients with elevated alanine aminotransferase. The expression of CD160, NKG2 D and NKG2 C activating receptor by CD8+ T cells were significantly lower in patients with chronic HCV hepatitis than in healthy controls and in HCV carriers with PNALT. Plasma TGF-β1 levels inversely correlated with NKG2 D expression by NK cells. In vitro TGF-β1 treatment inhibited NK cells cytotoxic activity and downregulated NKG2 D expression. CD8+ T cells from HCV carriers with PNALT showed significantly elevated expression of CD160, NKG2 D and NKG2 C activating receptors compared to chronic HCV patients with elevated alanine aminotransferase. Enhanced expression of inhibitory KIR2DL3 receptor, and decreased ILT-2 expression on NK cells were also found in chronic hepatitis C patients compared to healthy controls.CONCLUSION: Our study demonstrated a complex dysregulation of activating and inhibitory receptor expression, such as decreased NKG2 D and CD160 activating receptor expression and increased KIR2DL3 inhibitory receptor expression by NK and cytotoxic T cells and may provide further mechanism contributing to defective cellular immune functions in chronic hepatitis C. Increased NKG2 D receptor expression in HCV patients with persistently normal ALT suggests an important pathway for sustaining NK and CD8 T cell function and a protective role against disease progression. | Laszlo Szereday Matyas Meggyes Melinda Halasz Julia Szekeres-Bartho Alajos Par Gabriella Par | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 11 | A Versatile Phenotyping System and Analytics Platform Reveals Diverse Temporal Responses to Water Availability in Setaria显示文摘Phenotyping 在使用大规模 genomic 数据理解并且改善农业庄稼成为了限制率的步。这里,为控制环境植物生长的系铃羊 Phenotyping 站台和 automatedmultimodal phenotyping 被描述。系统为 1140 植物有能力,它每天通过车站过去记录荧光,在红外线附近、可见的图象。植物计算机视觉(PlantCV ) 作为公开源码被开发,硬件为量的图象分析的与平台无关的软件。在一个 4 星期的实验,野 Setaria viridisand 驯养了 Setaria italica 有根本上不同的时间的回答浇可获得性。当两根线在有限的水条件下面生产了生物资源的类似的层次时, Setaria viridis 在水下面维持了一样的水使用效率饱满条件,当 Setaria italica 变了到不太有效的生长时。总的来说,系铃羊 Phenotyping 平台和 PlantCV 软件在高度,生物资源,水使用效率,颜色,植物建筑学,和织物水上检测了 genotypeand 环境的重要效果地位特点。在实验的功课期间获得的所有 ∼79000 图象是公开可得到的。 | Noah Fahlgren Maximilian Feldman Malia A. Gehan Melinda S. Wilson Christine Shyu Douglas W. Bryant Steven T. Hill Colton J. McEntee ankalpi N. Warnasooriya Indrajit Kumar Tracy Ficor Stephanie Turnipseed Kerrigan B. Gilbert Thomas P. Brutnell James C. Carrington Todd C. Mockler Ivan Baxter | 2015 | Molecular Plant2015，8，10： | 4 |
| 12 | 加拿大萨斯喀彻温省Bakken组致密油生产特征及甜点分布预测显示文摘为对加拿大萨斯喀彻温省东南部Williston盆地中Bakken段致密油产区'甜点'进行预测,在大量生产数据分析基础上,根据致密油生产井产量与成藏要素间的定量关系,提出了一套识别潜在'甜点'的多元统计方法。在筛选和分析控制油气'甜点'地质要素的过程中,发现一些制约常规油气成藏的地质因素同样适用于中Bakken段致密油区,这些因素包括:(1)北东走向的Torqunay-Rocanville构造带可能是连接Williston盆地南部成熟烃源岩灶和研究区内Bakken组致密储集层之间的主要油气运移通道;(2)美国和加拿大边界Bakken段致密储集层中的油可能由当地局部成熟的Bakken组烃源岩提供;(3)正向构造有利于油气聚集;(4)顶部盖层和侧向封堵有利于油气的聚集与保存,从而增加单井产量;(5)单井最终可采储量方向变差函数的空间连续性方向与最大水平应力方向一致,水平井的走向对致密油的产量有实质影响。 | 谌卓恒 杨潮 姜春庆 KOHLRUSS Dan 胡克珍 刘晓军 YURKOWSKI Melinda | 2018 | 石油勘探与开发2018，45，4： | 4 |
| 13 | Photocatalytic reduction of CO2 with H2O over modified TiO2 nanofibers: Understanding the reduction pathway显示文摘Nanosized 金属(磅或 Pd ) 装饰了 TiO 2 nanofibers (NF ) 被一个湿受精方法综合。CdSe 量点(QD ) 然后被抛锚到装饰金属的 TiO 2 NF 上。这些催化剂的 photocatalytic 表演在 UV-B 光下面为公司 2 的激活和减小被测试。煤气的色析法的分析作为主要产品显示了甲醇,蚁的酸,和甲基甲酸盐的形成。当 CdSe QD 不在时,装饰 Pd 的 TiO 2 NF 被发现为甲醇生产与装饰磅的 TiO 2 NF 相比展出提高的性能。面对 CdSe,然而,装饰磅的 TiO 2 NF 为甲醇展出了更高的选择,典型地生产 90 ppmg 1 祴愠潠 { 琠敨朠潲瑷 ? 楤敲瑣潩 ? 景琠敨渠湡牯摯 ? 桷捩 ? 獩爠畯桧祬 ??? S 吗?? | Anjana Sarkar Eduardo Gracia-Espino Thomas Wagberg Andrey Shchukarev Melinda Mohl Anne-Riikka Rautio Olli Pitkanen Tiva Sharifi Krisztian Kordas Jyri-Pekka Mikkola | 2016 | Nano Research2016，9，7： | 4 |
| 14 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 15 | Genome-wide association studies in apple reveal loci of large effect controlling apple polyphenols显示文摘Apples are a nutritious food source with significant amounts of polyphenols that contribute to human health and wellbeing,primarily as dietary antioxidants.Although numerous pre-and post-harvest factors can affect the composition of polyphenols in apples,genetics is presumed to play a major role because polyphenol concentration varies dramatically among apple cultivars.Here we investigated the genetic architecture of apple polyphenols by combining high performance liquid chromatography(HPLC)data with~100,000 single nucleotide polymorphisms(SNPs)from two diverse apple populations.We found that polyphenols can vary in concentration by up to two orders of magnitude across cultivars,and that this dramatic variation was often predictable using genetic markers and frequently controlled by a small number of large effect genetic loci.Using GWAS,we identified candidate genes for the production of quercitrin,epicatechin,catechin,chlorogenic acid,4-O-caffeoylquinic acid and procyanidins B1,B2,and C1.Our observation that a relatively simple genetic architecture underlies the dramatic variation of key polyphenols in apples suggests that breeders may be able to improve the nutritional value of apples through markerassisted breeding or gene editing. | Kendra AMcClure YuiHui Gong Jun Song Melinda Vinqvist-Tymchuk Leslie Campbell Palmer Lihua Fan Karen Burgher-MacLellan ZhaoQi Zhang Jean-Marc Celton Charles FForney ZoëMigicovsky Sean Myles | 2019 | Horticulture Research2019，6，1： | 3 |
| 16 | 英中印三国的干细胞战略显示文摘干细胞科学全球化正日益受到亚太地区新兴经济体的影响。中国、印度、韩国和新加坡等国在遭受了科技商业化的挫折和沮丧之后,正在构建多种创新、政策和投资新模式,向欧美正统模式发起挑战。这份报告调研了英国、中国和印度在干细胞科学全球化进程中所处的位置,对中印两国如何适应这个领域不断发展的知识市场做了深入分析,特别是详尽评价了中印两国对具有无限前景的生物经济作出的特别贡献。 | Brian Saltce Melinda Cooper Amanda Dickins Valentina Cardo 陈丽媛(编译) | 2007 | 生物技术世界2007，，2： | 3 |
| 17 | Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn’s disease and psoriasis显示文摘 | Eniko Safrany Melinda Szabo Marta Szell Lajos Kemeny Katalin Sumegi Bela I. Melegh Lili Magyari Petra Matyas Maria Figler Agnes Weber Zsolt Tulassay Bela Melegh | 2013 | Inflammation Research2013，，2： | 3 |
| 18 | LJItrasensitive H2S gas sensors based on p-type WS2 hybrid materials显示文摘 | Georgies Alene Asrest Jose J. Baldovi Aron Dombovari Topias Jarvinen Gabriela Simone Lorite Melinda Mohl Andrey Shchukarev Alejandro Perez Paz Lede Xian Jyri-Pekka Mikkola Anita Lloyd Spetz Heli Jantunen Angel Rubio Krisztian Kordas | 2018 | Nano Research2018，11，8： | 3 |
| 19 | Survival After Resection of Ampullary Carcinoma: A National Population-Based Study显示文摘 | Jessica B. O'Connell MD Melinda A. Maggard MD Jesse Manunga MD James S. Tomlinson MD Howard A. Reber MD Clifford Y. Ko MD O. Joe Hines MD | 2008 | Annals of Surgical Oncology2008，，7： | 2 |
| 20 | Colorectal cancer in the young显示文摘 | Jessica B O’Connell Melinda A Maggard Edward H Livingston Cifford K Yo | 2004 | The American Journal of Surgery2004，，： | 2 |
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