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| 1 | Effect of thrombectomy on oedema progression and clinical outcome in patients with a poor collateral profile显示文摘Background and purpose The impact of the cerebral collateral circulation on lesion progression and clinical outcome in ischaemic stroke is well established.Moreover,collateral status modifies the effect of endovascular treatment and was therefore used to select patients for therapy in prior trials.The purpose of this study was to quantify the effect of vessel recanalisation on lesion pathophysiology and clinical outcome in patients with a poor collateral profile.Materials and methods 129 patients who had an ischaemic stroke with large vessel occlusion in the anterior circulation and a collateral score(CS)of 0-2 were included.Collateral profile was defined using an established 5-point scoring system in CT angiography.Lesion progression was determined using quantitative lesion water uptake measurements on admission and follow-up CT(FCT),and clinical outcome was assessed using modified Rankin Scale(mRS)scores after 90 days.Results Oedema formation in FCT was significantly lower in patients with vessel recanalisation compared with patients with persistent vessel occlusion(mean 19.5%,95%CI:17%to 22%vs mean 27%,95%CI:25%to 29%;p<0.0001).In a multivariable linear regression analysis,vessel recanalisation was significantly associated with oedema formation in FCT(ß=−7.31,SD=0.015,p<0.0001),adjusted for CS,age and Alberta Stroke Program Early CT Score(ASPECTS).Functional outcome was significantly better in patients following successful recanalisation(mRS at day 90:4.5,IQR:2-6 vs 5,IQR:5-6,p<0.001).Conclusion Although poor collaterals are known to be associated with poor outcome,endovascular recanalisation was still associated with significant oedema reduction and comparably better outcome in this patient group.Patients with poor collaterals should not generally be excluded from thrombectomy. | Gabriel Broocks Andre Kemmling Tobias Faizy Rosalie McDonough Noel Van Horn Matthias Bechstein Lukas Meyer Gerhard Schon Jawed Nawabi Jens Fiehler Helge Kniep Uta Hanning | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 2 | Outstanding performance of activated graphene based supercapacitors in ionic liquid electrolyte from ?50 to 80<ce:hsp sp='0.25'/>°C显示文摘 | Wan-Yu Tsai Rongying Lin Shanthi Murali Li Li Zhang John K. McDonough Rodney S. Ruoff Pierre-Louis Taberna Yury Gogotsi Patrice Simon | 2013 | Nano Energy2013，，3： | 2 |
| 3 | The Management of Acute Thoracolumbar Burst Fractures with Anterior Corpectomy and Z-Plate Fixation显示文摘 | Paul W. McDonough Rick Davis Clifford Tribus Thomas A. Zdeblick | 2004 | Spine2004，，17： | 2 |
| 4 | The management of acute thoracolumbar burst fractures with anterior corpectomy and Z - plate fixation 显示文摘 | Paul W McDonough MD Rick D | 2004 | Spine2004，29，： | 1 |
| 5 | Structral Characteristics of Steam-Flaked Sorghum显示文摘 | C M McDonough B J Anderson L W Rooney | 1997 | Cereal Chem1997，74，5： | 1 |
| 6 | Increase fusion rates with cervical plating for two-level cervical discectomy and fusion显示文摘 | Wang JC McDonough PW Endow KK | 2000 | Spine2000，25，： | 1 |
| 7 | Neurochemical mechanisms in soman-induced seizures显示文摘 | Shih TM McDonough JH Jr | 1997 | J Appl Toxicol1997，17，4： | 1 |
| 8 | The composition of the Earth显示文摘 | McDonough W F Sun S S | 1995 | Chemical Geology1995，120，34： | 1 |
| 9 | Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter trylori infection 显示文摘 | Straubinger RK Greiter A McDonough SP | 2003 | Infect Immune2003，71，5： | 1 |
| 10 | Whey protein concentrate as a milk extender显示文摘 | McDonough F E Alford J A Womack M | 1976 | J Dairy Sci1976，59，： | 1 |
| 11 | The composition of the Earth 显示文摘 | McDonough W F Sun S S | 1995 | Chemical Geology1995，120，： | 1 |
| 12 | Tracking the budget of Nb and Ta in the continental crust显示文摘 | Barth M G McDonough W F Rudnick R L | 2000 | Chemical Ge- ology2000，165，34： | 1 |
| 13 | Sepsis-inducedapoptosis leads to active suppression of delayed-type hypersen-sitivity by CD8+regulatory T cells through a TRAIL-dependentmechanism显示文摘 | Unsinger J Kazama H McDonough JS | 2010 | J Immunol2010，184，12： | 1 |
| 14 | Increased fu- sion rates with cervical plating for two-level anterior cervical discectomy and fuslon显示文摘 | Wang JC Mcdonough PW Endow KK | 2000 | Spine2000，25，1： | 1 |
| 15 | Treatment with tertiary oximes prevents seizures and improves survival following satin intoxication显示文摘 | Shih TM Skovira JW McDonough JH | 2010 | J Mol Neurel2010，40，12： | 1 |
| 16 | Selective inhibition of ~ctor inhibiting hypoxia-inducible factor 显示文摘 | McDonough M A McNeill L A Tilliet M | 2005 | JAm Chem Soc2005，127，21： | 1 |
| 17 | Skeletal muscle regulates extracellular potassium显示文摘 | MCDONOUGH A A THOMPSON C B YOUN J H | 2002 | American Journal of Physiology:Renal Physiology2002，282，6： | 1 |
| 18 | Investigating the role of leadership and organizational culture in fostering in- novation ambidexterity显示文摘 | LIN HSING - ER MCDONOUGH III EDWARD F | 2011 | IEEE Transactions on Engineering Management2011，58，3： | 1 |
| 19 | Neurochemical mechanisms in soman-induced seizures显示文摘 | Shih TM McDonough JH | 1997 | J Appl Toxicol1997，17，4： | 1 |
| 20 | Memory′s aging echo: age-related decline in neural reactivation of perceptual details during recollection显示文摘 | McDonough IM Cervantes SN Gray SJ | 2014 | Neuroimage2014，98，： | 1 |
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