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| 1 | Immunological changes in different patient populations with chronic hepatitis C virus infection显示文摘AIM: To investigate killer inhibitory and activating receptor expression by natural killer(NK), natural killer T-like(NKT-like) and CD8+ T lymphocytes in patients with chronic hepatitis C virus(HCV) infection with elevated and with persistently normal alanine aminotransferase(PNALT).METHODS: The percentage of peripheral blood Treg cells, KIR2DL3, ILT-2, KIR3DL1, CD160, NKG2 D, NKG2 C expressing NK, T and NKT-like cells, cytokine production and NK cytotoxicity were determined by flow cytometry. Twenty-one patients with chronic HCV infection with elevated alanine aminotransferase, 11 HCV carriers with persistently normal alanine aminotransferase and 15 healthy volunteers were enrolled. RESULTS: No significant differences were observed in the percentage of total T, NK or NKT-like cells between study groups. Comparing the activating and inhibitoryreceptor expression by NK cells obtained from HCV carriers with PNALT and chronic HCV hepatitis patients with elevated alanine aminotransferase, NKG2 D activating receptor expression was the only receptor showing a significant difference. NKG2 D expression of NK cells was significantly lower in patients with elevated alanine aminotransferase. The expression of CD160, NKG2 D and NKG2 C activating receptor by CD8+ T cells were significantly lower in patients with chronic HCV hepatitis than in healthy controls and in HCV carriers with PNALT. Plasma TGF-β1 levels inversely correlated with NKG2 D expression by NK cells. In vitro TGF-β1 treatment inhibited NK cells cytotoxic activity and downregulated NKG2 D expression. CD8+ T cells from HCV carriers with PNALT showed significantly elevated expression of CD160, NKG2 D and NKG2 C activating receptors compared to chronic HCV patients with elevated alanine aminotransferase. Enhanced expression of inhibitory KIR2DL3 receptor, and decreased ILT-2 expression on NK cells were also found in chronic hepatitis C patients compared to healthy controls.CONCLUSION: Our study demonstrated a complex dysregulation of activating and inhibitory receptor expression, such as decreased NKG2 D and CD160 activating receptor expression and increased KIR2DL3 inhibitory receptor expression by NK and cytotoxic T cells and may provide further mechanism contributing to defective cellular immune functions in chronic hepatitis C. Increased NKG2 D receptor expression in HCV patients with persistently normal ALT suggests an important pathway for sustaining NK and CD8 T cell function and a protective role against disease progression. | Laszlo Szereday Matyas Meggyes Melinda Halasz Julia Szekeres-Bartho Alajos Par Gabriella Par | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 2 | Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn’s disease and psoriasis显示文摘 | Eniko Safrany Melinda Szabo Marta Szell Lajos Kemeny Katalin Sumegi Bela I. Melegh Lili Magyari Petra Matyas Maria Figler Agnes Weber Zsolt Tulassay Bela Melegh | 2013 | Inflammation Research2013，，2： | 3 |
| 3 | Metabolic changes in the lower esophageal sphincter influencing the result of anti-reflux surgical interventions in chronic gastroesophageal reflux disease显示文摘AIM: With the availability of a minimally invasive approach, anti-reflux surgery has recently experienced a renaissance as a cost-effective alternative to life-long medical treatment in patients with gastroesophageal reflux disease (GERD). We are not aware of the fact whether reflux episodes causing complaints for a long time i.e., at least for one year are associated with metabolic changes in the lower esophageal sphincter, and if so,whether these may influence functional results achieved after anti-reflux surgery.METHODS: Between 1 January 2001 and 31 December 2002 we performed anti-reflux surgery on 79 patients.Muscle samples were taken from the lower esophageal sphincter (LES) in 33 patients during anti-reflux surgery.Inclusion criteria were: LES resting pressure below 10 mmHg and a marked, pH proven acid exposure to the esophagus of at least one year's duration, causing subjective complaints and requiring continuous proton pump inhibitor treatment. Control samples were obtained from muscle tissue in the gastroesophageal junction that had been removed from 17 patients undergoing gastric or esophageal resection. Metabolic and lysosomal enzyme activities and special protein concentrations 16 parameters in total were evaluated in tissue taken from control specimens and tissue taken from patients with GERD. The biochemical parameters of these intra-operative biopsies were used to correlate the results of anti-reflux operations (Visick I and II-III).RESULTS: In the reflux-type muscle, we found a significant increase of the energy-enzyme activities e.g., creatine kinase, lactate dehydrogenase, β-hydroxybutyrate dehydrogenase, and aspartate aminotransaminase-. The concentration of the structural protein S-100 and the myofibrillar protein troponin I were also significantly increased. Among lysosomal enzymes, we found that the activities of cathepsin B, tripeptidyl-peptidase I, dipeptidylpeptidase II, β-hexosaminidase B, β-mannosidase and β-galactosidase were significantly decreased as compared to the control LES muscles. By analyzing the activity values of the 9 patients in Visick groups Ⅱ and Ⅲ at two months post-surgery, we found a significant increase in the activity of the so-called energy-enzyme values and in the concentration of structural and myofibrillar proteins as compared to the rest of the reflux patients.CONCLUSION: Our results call attention to the metabolic changes that occurred in the LES muscles of reflux patients. The developing hypertrophy-like changes of LES muscles may be a reason for complaints after anti-reflux surgery, which consisted mainly of reports of persisting dysphagia. | Aron Altorjay Arpad Juhasz Viola Kellner Gellert Sohar Matyas Fekete Istvan Sonar | 2005 | World Journal of Gastroenterology2005，11，11： | 2 |
| 4 | The roles of microRNA in redox metabolism and exercise-mediated adaptation显示文摘MicroRNAs(miRs)are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex.miRs are involved in the regulation of cellular processes producing,eliminating or repairing the damage caused by reactive oxygen species,and they are active players in redox homeostasis.Increased mitochondrial biogenesis,function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise.In the present review,we highlight some of the redox-sensitive regulatory roles of miRs. | Ferenc Torma Zoltan Gombos Matyas Jokai Istvan Berkes Masaki Takeda Tatsuya Mimura Zsolt Radak Ferenc Gyori | 2020 | Journal of Sport and Health Science2020，9，5： | 2 |
| 5 | Ballistic Testing and Thermal Behavior of Cast Double-base Propellant Containing BuNENA显示文摘Preparation of cast double-propellant grains depends on the ability of nitrocellulose powder to swell and coalesce into a coherent mass when treated with a suitable solvent.The cast double-base process has been developed into a highly versatile technique for manufacturing solid rocket charges.Propellants manufactured by this process provide a wide range of energies and burning rates.Successful preparation of cast double-base propellant grains has been performed using compatible casting liquid with the casting powder.BuNENA was used as an energetic plasticizer for manufacturing of casting powder.Burning rate measurements have been performed using closed bomb SV-2to investigate the burning behavior along a wide range of operating pressure.Plateau burning had been detected in pressure range(50-70)×105 Pa for the composition included BuNENA.DTA and TGA thermal analysis were conducted to evaluate the thermal behavior of the prepared cast double-base propellants.Results from DTA were used to calculate the apparent activation energy. | Ahmed Maraden Petr Stojan Robert Matyas Jan Zigmund | 2017 | 火炸药学报2017，40，6： | 2 |
| 6 | Effect of hydrocele on appendix testis in children显示文摘这研究的目的是在孩子在结构的完整和附录睾丸的类固醇受体表达式模式上调查阴囊积水的一个提高的静水力学的压力的效果。26 个阴囊的附器从男孩被获得(在 13 和 79 个月之间年老,平均数 40 月) 因为阴囊积水或先天的腹股沟的脱肠,经历了外科的探索。阴囊的附器的织物节与 hematoxylin 曙红被染色。Immunohistochemistry 和 immunofluorescence 激光显微镜学用 monoclonal 老鼠被执行对雄激素的反人的受体和雌激素受体。病人们被划分成三个组:组 A (n = 8 ) 有没有阴囊积水的腹股沟脱肠的代表的病人,用作控制组织;组 B (n = 7 ) 有传达阴囊积水的代表的病人;并且组织 C (n = 11 ) 有 noncommunicating 阴囊积水的代表的病人。附录睾丸的织物节在组 A 在所有病人表示了雄激素和雌激素受体, B,和上皮的破坏不是现在。雄激素受体的存在(11 中的二个, P < 0.001 ) 并且雌激素受体(11 中的四个, P = 0.006 ) 更低,有上皮的破坏的附录睾丸的数字更高(11 中的八个, P = 0.001 ) 在组 C。我们证明那腹股沟脱肠和交流阴囊积水没影响受体表示模式和阴囊的附器的解剖结构,而 noncommunicating 阴囊积水引起了由类固醇受体和上皮的表面的破坏的缺席显示了的损坏。阴囊的附器的生理的角色的更好的理解可以与 noncommunicating 阴囊积水在病人改变外科的治疗的指示。 | Tamas Jozsa Andrea Telek Balazs Kutasy Matyas Benyo Gabor Csanadi Ilona Kovacs Gyorgy Balla Tibor Flasko Laszlo Csernoch Csongor Kiss | 2009 | Asian Journal of Andrology2009，11，6： | 2 |
| 7 | The three-dimensional architecture of the notochordal nucleus pulposus:novel observations on cell structures in the canine intervertebral disc显示文摘 | Hunter CJ Matyas JR Duncan NA | 2003 | J Anat2003，202，3： | 1 |
| 8 | Can simultaneous bilateral movement involve the undamaged hemisphere in reconstruction of neural networks damaged by stroke?显示文摘 | Mudie MH Matyas TA | 2000 | Disabil Rehabil2000，22，12： | 1 |
| 9 | Brucellosis as a world problem显示文摘 | Matyas Z Fujikura T | 1984 | Dev Biol Stand1984，56，： | 1 |
| 10 | Upper extremity retraining following stroke:effects of bilateral practice 显示文摘 | Mudie MH Matyas TA | 1996 | Journal of Neurological Rehabilitation1996，10，： | 1 |
| 11 | Effects ofdisinfectants on dimentional accuracy of impression materials显示文摘 | Matyas J Dao N Caputo FM | | 0，，01： | 1 |
| 12 | Cryptographic authentication of time-invariant quantities显示文摘 | Lennon R Matyas S M Meyer C H | 1981 | IEEE Trans Commun1981，29，6： | 1 |
| 13 | Pregnancy achieved by transfer of a single blastocyst selected by time-lapse monitoring 显示文摘 | Pribenszky C Matyas S Kovacs P | 2010 | Reprod Biomed Online2010，21，4： | 1 |
| 14 | Persistent DNA contamination in competitive RT-PCR using cRNA internal standards:Identity,quantity,and control显示文摘 | Matthews J L Chung M Matyas R J | 2002 | Biotechniques2002，32，6： | 1 |
| 15 | Prediction of vertical earth loads on rigid pipes显示文摘 | Davis J B | 1983 | Journal of Geotechnical Engineering ASCE1983，109，2： | 1 |
| 16 | Volume change characteristics of partially saturated soils显示文摘 | MATYAS E L RADHAKRISHNA H S | 1968 | Geotechnique1968，18，4： | 1 |
| 17 | Message authentication 显示文摘 | JUENEMAN R MATYAS S MEYER C | 1988 | IEEE Communications Magazine1988，，9： | 1 |
| 18 | Indirect effect of different fish communities on nutrient chlorophyll relationship in shallow hypertrophic water quality reservoirs显示文摘 | Matyas K Oldal I Korponai J | 2003 | Hydrobiologia2003，504，13： | 1 |
| 19 | HV impulse measuring system analysis and qualification by estimation of measurement errors via FFT,convolution,and IFFT显示文摘 | Matyas Z Aro M | | 0，，05： | 1 |
| 20 | Brucellosis as a world problem显示文摘 | Matyas Z Fujikura T | 1984 | Dev Biol Stand1984，56，7： | 1 |
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