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| 1 | Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis显示文摘AIM: To detect pancreatic neuroendocrine tumors (PNETs) has been varied. This study is undertaken to evaluate the accuracy of endoscopic ultrasound (EUS) in detecting PNETs.METHODS: Only EUS studies confirmed by surgery or appropriate follow-up were selected. Articles were searched in Medline, Ovid journals, Medline nonindexed citations, and Cochrane Central Register of Controlled Trials and Database of Systematic Reviews. Pooling was conducted by both fixed and random effects model). RESULTS: Initial search identified 2610 reference articles, of these 140 relevant articles were selected and reviewed. Data was extracted from 13 studies (n = 456) which met the inclusion criteria. Pooled sensitivity of EUS in detecting a PNETs was 87.2% (95%CI: 82.2-91.2). EUS had a pooled specificity of 98.0% (95%CI: 94.3-99.6). The positive likelihood ratio of EUS was 11.1 (95%CI: 5.34-22.8) and negative likelihood ratio was 0.17 (95%CI: 0.13-0.24). The diagnostic odds ratio, the odds of having anatomic PNETs in positive as compared to negative EUS studies was 94.7 (95%CI: 37.9-236.1). Begg-Mazumdar bias indicator for publication bias gave a Kendall's tau value of 0.31 (P = 0.16), indication no publication bias. The P for χ2 heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity to detect PNETs. EUS should be strongly considered for evaluation of PNETs. | Srinivas R Puli Nikhil Kalva Matthew L Bechtold Smitha R Pamulaparthy Micheal D Cashman Norman C Estes Richard H Pearl Fritz-Henry Volmar Sonu Dillon Michael F Shekleton David Forcione | 2013 | World Journal of Gastroenterology2013，19，23： | 14 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Optimization of Thermoelectric Green Tape Characteristics Made by the Tape Casting Method显示文摘 | Salam L A Matthews R D Robertson H | 2000 | Mater Chem Phys2000，62，： | 1 |
| 5 | Shape-memory behavior of estimulated polyurethane for medical applications显示文摘 | Baer G Wilson T S Matthews D L | 2007 | Journal of Applied Polymer Science2007，103，6： | 1 |
| 6 | Microbial community structure and denitrification in a wetland mitigation bank 显示文摘 | electrophoresis analysis of electrophoresis ( TGGE ) in Per'alta A L Matthews J W Kent A D | 2010 | Appl Environ Microbiol2010，76，13： | 1 |
| 7 | Institutional repositories: evaluating the reasons for non-use of Comell University's Installation of DSpaee 显示文摘 | Philip M D Matthew J L | 2007 | D-Lib Magazine2007，13，34： | 1 |
| 8 | Review of the pest sta- tus and control options for Thrips palmi显示文摘 | Cannon R J C Matthews L Collins A D W | 2007 | Crop Protection2007，26，8： | 1 |
| 9 | Sudden cardiac death and inherited channelopathy:the basic electrophysiology of the myocyte and myocardium in ion channel disease显示文摘 | MARTIN C A MATTHEWS G D HUANG C L | 2012 | Heart2012，98，7： | 1 |
| 10 | Effects of hetaine , pen space, and slaughter handling method on growthper formance, carcass traits, and pork quality of finishing barrows显示文摘 | Matthews J O Southern L L Bidner T D | 2001 | J Anim Sci2001，79，： | 1 |
| 11 | Caspase-9, caspase-3 and easpase-7 have distinct roles during in- trinsic apoptosis显示文摘 | MATTHEW B LUIS R M REBEKA L D G | 2013 | BMC Cell Biology2013，，14： | 1 |
| 12 | Alcohol inhibits NR2B-containing NMDA receptors in the ventral bed nucleus of the striaterminalis显示文摘 | Kash T L Matthews R T Winder D G | 2008 | Neuropsychopharmacology2008，33，： | 1 |
| 13 | Data mining for simple sequence repeats in expressed sequence tags from barley,maize,rice,sorghum and wheat显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Mol Biol2002，48，： | 1 |
| 14 | Effect of chromium propionate and metabolizable energy on growth, carcass traits, and pork quality of growing-finishing pig显示文摘 | Matthews J O Higbie A D Southern L L | 2003 | J Anim Sci2003，81，： | 1 |
| 15 | The effect of neoprene shorts on leg proprioception in Australian football players显示文摘 | MATTHEW L CAMERON ROGER D ADAMS CHRIS G MAHER B | 2008 | Journal of Science and Medicine in Sport2008，11，： | 1 |
| 16 | Influence of microstructure on the corrosion of diecast AZ91D显示文摘 | Song G L Andrej A Matthew D | 1999 | Corrosion Science1999，41，2： | 1 |
| 17 | Transformation and segregation of GFP fluorescence and glyphosate resistance in horseweed (Conyza canadensis) hybrids显示文摘 | Matthew D Halfhill Raura L | 2007 | Plant Cell Reports2007，26，3： | 1 |
| 18 | 查看详情显示文摘 | Matthews D L Campbell E M Ceglio N M Hermes G Kauffman R Koppel L Lee R Manes K Rupert V Slivinsky W Turner R Ze F | | 0，，： | 1 |
| 19 | Data mining for simple sequence repeats in expressed sequence tags from barley, maize, rice, sorghum and wheat显示文摘 | Kantety R V Rota M L Matthews D E | 2002 | Plant Mol Biol2002，48，： | 1 |
| 20 | Extracorporeal therapies in the treatment of sepsis: experience and promise显示文摘 | James D Matthew L | 2006 | Pediatr Infect Dis2006，17，2： | 1 |
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