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| 1 | The omentum显示文摘INTRODUCTIONThe word omentum derives from the ancientEgyptians who,when embalming human bodies,used to assess their'omens'by looking at thevariations in what we recognise today as theomentum.Galen(128-199 AD)thought that therole of the omentum was to warm the intestines.This was on the basis of a gladiator who had anomental resection after a stab injury and sufferedgreatly from cold for the rest of his life.A | Cameron Platell Deborah Cooper John M.Papadimitriou John C.Hall | 2000 | World Journal of Gastroenterology2000，6，2： | 57 |
| 2 | Effectiveness of exercise in hepatic fat mobilization in nonalcoholic fatty liver disease: Systematic review显示文摘AIM: To investigate the efficacy of exercise interventions on hepatic fat mobilization in non-alcoholic fatty liver disease(NAFLD) patients.METHODS: Ovid-Medline, Pub Med, EMBASE and Cochrane database were searched for randomized trials and prospective cohort studies in adults aged ≥ 18 which investigated the effects of at least 8 wk of exercise only or combination with diet on NAFLD from 2010 to 2016. The search terms used to identify articles, in which exercise was clearly described by type, duration, intensity and frequency were: 'NASH', 'NAFLD', 'nonalcoholic steatohepatitis', 'non-alcoholic fatty liver disease', 'fat', 'steatosis', 'diet', 'exercise', 'MR spectroscopy' and 'liver biopsy'. NAFLD diagnosis, as well as the outcome measures, was confirmed by either hydrogen-magnetic resonance spectroscopy(H-MRS) or biopsy. Trials that included dietary interventions along with exercise were accepted if they met all criteria. RESULTS: Eight studies met selection criteria(6 with exercise only, 2 with diet and exercise with a total of 433 adult participants). Training interventions ranged between 8 and 48 wk in duration with a prescribed exercise frequency of 3 to 7 d per week, at intensities between 45% and 75% of VO2 peak. The most commonly used imaging modality was H-MRS and one study utilized biopsy. The effect of intervention on fat mobilization was 30.2% in the exercise only group and 49.8% in diet and exercise group. There was no difference between aerobic and resistance exercise intervention, although only one study compared thetwo interventions. The beneficial effects of exercise on intrahepatic triglyceride(IHTG) were seen even in the absence of significant weight loss. Although combining an exercise program with dietary interventions augmented the reduction in IHTG, as well as improved measures of glucose control and/or insulin sensitivity, exercise only significantly decreased hepatic lipid contents.CONCLUSION: Prescribed exercise in subjects with NAFLD reduces IHTG independent of dietary intervention. Diet and exercise was more effective than exercise alone in reducing IHTG. | Pegah Golabi Cameron T Locklear Patrick Austin Sophie Afdhal Melinda Byrns Lynn Gerber Zobair M Younossi | 2016 | World Journal of Gastroenterology2016，22，27： | 30 |
| 3 | MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma显示文摘Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey | 2010 | World Journal of Gastroenterology2010，16，5： | 23 |
| 4 | Ischemic cholangiopathy after livertransplantation显示文摘Orthotopic liver transplantation ( OLT) has evolved over the last forty years from an experimental endeavor to standard of care therapy for many patients with end stage hepatic disease. Many technical advances have contributed to the current success of OLT, but surgical complications, especially involving the biliary reconstruction, remain a morbid problem. Biliary complications after OLT include leaks and strictures. Strictures may be anastoinotic or intrahepatic and diffuse, as seen in cases of hepatic artery thrombosis. Current efforts to expand the limited donor pool include the use of non-heart beating donors. The organ procurement process in these donors entails an increased period of warm ischemia and results with non-heart beating donor grafts have been mixed. It is now appreciated that there is an increased incidence of subsequent diffuse biliary stricturing or ' ischemic cholangiopathy' in recipients of these organs. Animal models of this phenomenon and potential therapeutic strategies targeted at ischemic cholangiopathy are being developed with potential applicability to non-heart beating donation and will be the focus of this review. | Andrew M. Cameron Ronald W. Busuttil | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，4： | 22 |
| 5 | Management and prevention of acute and chronic lateral ankle instability in athletic patient populations显示文摘Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance. | Brendan J Mc Criskin Kenneth L Cameron Justin D Orr Brian R Waterman | 2015 | World Journal of Orthopedics2015，6，2： | 20 |
| 6 | 上海市基本药物可负担性实证研究显示文摘采用世界卫生组织(World Health Organization,WHO)和国际健康行动机构(Health Action Internation-al,HAI)发展的标准调查方法[1]对上海市药品价格可负担性进行调查,选择上海市场上销售的41种药品,调查其价格水平。选择了6种常见病,按照WHO标准治疗指南,以2006年上海市人均最低工资线750元(日均25元)为标准计算上海药品治疗费用的消费者可负担性,同时比较了患者使用品牌药与等效仿制药品的费用可负担性。 | 叶露 胡善联 Margaret Ewen Alecandra Cameron Richard Laing | 2008 | 中国卫生资源2008，11，4： | 17 |
| 7 | 近200a来珠穆朗玛峰北坡远东绒布冰芯气候记录显示文摘1997年 5月中美联合珠穆朗玛峰地区绒布冰川考察期间,在远东绒布冰川海拔 6 500 m的北 支冰流粒雪盆内钻取到一支41m长冰芯.通过数年层法并根据β活化度的参照年(1954年和 1963 年),对远东绒布冰芯实施定年,冰芯底部为 1814年,冰芯年平均净积累量为 224 mm(冰当 量).根据远东绒布冰芯 (δ18O的变化,重建了珠穆朗玛峰北坡地区近 200 a气候变化,发现有 5次冷 期和5次暖期,且总趋势为变暖,这与本世纪北半球气候变暖的趋势相一致.远东绒布冰芯气候记 录同古里雅冰芯比较,两者的冷暖波动较为一致,说明青藏高原西北部和南部地区的气候变化具有 共性.但是,远东绒布冰芯中δ18O的变化在短时间尺度上与降水量变化存在某些反相关性,这种关 系并未影响到δ18O反映气温的长期变化趋势. | 康世昌 秦大河 Paul A. Mayewski Cameron P. Wake 任贾文 | 2000 | 冰川冻土2000，22，3： | 17 |
| 8 | 拥抱绿色发展新范式:中国碳中和政策框架研究显示文摘中国以及全球范围的碳中和共识与行动标志着工业革命后形成的传统发展范式逐渐落幕,一个新的绿色发展范式开始兴起。本文分析工业革命以来旧有发展范式的不可持续性,揭示绿色发展范式在发展目的、发展内容、发展方式以及发展普适性上,是对传统发展范式的一次深刻革命。在新的绿色发展范式框架下,本文重新思考经济学的基本问题如价值理论、财富的内涵和测度,以及个人和集体行为等,分析新发展范式转变对于重塑中国重要经济部门和系统的政策含义,并讨论了转型过程中体制机制、金融和技术创新等方面的重要保障,以及如何实现协调和平衡的转型。本文同时提出中国如何引领世界碳中和治理机制建设,并讨论了同世界实现绿色合作共赢的机遇和政策。 | 朱民 Nicholas Stern Joseph E.Stiglitz 刘世锦 张永生 李俊峰 Cameron Hepburn | 2023 | 世界经济2023，46，3： | 17 |
| 9 | 颅内血管神经介入治疗的适应证美国心脏协会心血管放射学和介入委员会、卒中委员会、心血管外科和麻醉委员会、外周血管病跨学科委员会以及护理质量和转归研究跨学科委员会的联合学术声明显示文摘颅内血管内介入是一种使用微侵袭血管内技术治疗脑血管病的方法。该专业领域在过去10年里取得了巨大进展,而且随着该学科得到越来越多的临床认可,这种进步的速度还在加快。 | Philip M. Meyers H. Christian Schumacher Randall T. Higashida Stanley L. Barnwell Mark A. Creager Rishi Gupta Cameron G. McDougall Dilip K. Pandey David Sacks Lawrence R. Wechsler 乔梵(译) 刘建民(译) 洪波(译) | 2009 | 国际脑血管病杂志2009，17，10： | 16 |
| 10 | Probiotics for gastrointestinal disorders: Proposed recommendations for children of the Asia-Pacific region显示文摘Recommendations for probiotics are available in several regions. This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region. Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed. Evidence-based recommendations and randomized controlled trials in the region were revised. Cultural aspects,health management issues and economic factors were also considered. Final recommendations were approved by applying the Likert scale and rated using the GRADE system. Saccharomyces boulardii CNCM I-745(Sb) and Lactobacillus rhamnosus GG(LGG) were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis. Lactobacillus reuteri could also be considered. Probiotics may be considered for prevention of(with the indicated strains): antibiotic-associated diarrhea(LGG or Sb); Clostridium difficile-induced diarrhea(Sb); nosocomial diarrhea(LGG); infantile colic(L reuteri) and as adjunct treatment of Helicobacter pylori(Sb and others). Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis. There is insufficient evidence for recommendations in other conditions. Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries. These need to be validated with local randomized-controlled trials. | Donald Cameron Quak Seng Hock Musal Kadim Neelam Mohan Eell Ryoo Bhupinder Sandhu Yuichiro Yamashiro Chen Jie Hans Hoekstra Alfredo Guarino | 2017 | World Journal of Gastroenterology2017，23，45： | 14 |
| 11 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 12 | 农民工犯罪类别的决定因素——基于监狱调查数据的实证分析显示文摘基于监狱调查数据,本文分析了农村户籍服刑人员和普通农民工之间,以及服刑人员内部在个人基本信息、性格特质和家庭背景三个维度上的差异。研究发现农民工罪犯主要参与暴力犯罪和盗窃。与农民工相比,服刑人员总体上年纪小,教育不足,认知能力和性格特征存在缺陷,兄弟姐妹多,母亲教育程度低。区分不同犯罪类型,以上特征多表现在暴力犯和盗窃犯身上;而涉毒犯和经济犯的特征为进城时间长、认知能力强和无差异的年龄及母亲教育程度。 | 张丹丹 王也 Xin Meng Lisa Cameron | 2014 | 经济学(季刊)2014，13，4： | 11 |
| 13 | DNA-informed breeding of rosaceous crops: promises, progress and prospects显示文摘Crops of the Rosaceae family provide valuable contributions to rural economies and human health and enjoyment.Sustained solutions to production challenges and market demands can be met with genetically improved new cultivars.Traditional rosaceous crop breeding is expensive and time-consuming and would benefit from improvements in efficiency and accuracy.Use of DNA information is becoming conventional in rosaceous crop breeding,contributing to many decisions and operations,but only after past decades of solved challenges and generation of sufficient resources.Successes in deployment of DNA-based knowledge and tools have arisen when the‘chasm’between genomics discoveries and practical application is bridged systematically.Key steps are establishing breeder desire for use of DNA information,adapting tools to local breeding utility,identifying efficient application schemes,accessing effective services in DNA-based diagnostics and gaining experience in integrating DNA information into breeding operations and decisions.DNA-informed germplasm characterization for revealing identity and relatedness has benefitted many programs and provides a compelling entry point to reaping benefits of genomics research.DNA-informed germplasm evaluation for predicting trait performance has enabled effective reallocation of breeding resources when applied in pioneering programs.DNA-based diagnostics is now expanding from specific loci to genome-wide considerations.Realizing the full potential of this expansion will require improved accuracy of predictions,multi-trait DNA profiling capabilities,streamlined breeding information management systems,strategies that overcome plant-based features that limit breeding progress and widespread training of current and future breeding personnel and allied scientists. | Cameron P Peace | 2017 | Horticulture Research2017，4，1： | 11 |
| 14 | 重载货车车轮热负荷问题的探讨显示文摘讨论了重载货车制动热负荷对车轮的影响,简要回顾在这方面已经取得的研究成果,并提供了计算机仿真分析的几个典型热制动工况下的应力和温度场结果,包括坡道制动工况和停车制动工况。对手制动作用于运行车轮的工况进行了分析,检验了不同闸瓦作用位置对温度场的影响,并介绍了与热负荷相关的车轮更换问题。 | Cameron Lonsdale 刘敬辉 马大炜 | 2005 | 国外铁道车辆2005，42，6： | 11 |
| 15 | The management of patients with the short bowe syndrome显示文摘The surgeon is invariably the primary specialist involvedin managing patients with short bowel syndrome. Becauseof this they will play an important role in co-ordinating themanagement of these patients. The principal aims at theinitial surgery are to preserve life, then to preserve gutlength, and maintain its continuity. In the immediatepostoperative period, there needs to be a balancebetween keeping the patient alive through the use of TPNand antisecretory agents and promoting gut adaptationwith the use of oral nutrition. lf the gut fails to adaptduring this period, then the patient may require therapywith more specific agents to promote gut adaptation suchas growth factors and glutamine. lf following this, thepatient still has a short gut syndrome, then the principaloptions remain either long term TPN, or intestinaltransplantation which remains a difficult and challengingprocedure with a high mortality and morbidity due torejection. | Cameron F.E.Platell Jane Coster Rosalie D.McCauley John C.Hall | 2002 | World Journal of Gastroenterology2002，8，1： | 11 |
| 16 | 系统综述与网状Meta分析的PRISMA扩展声明显示文摘PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展,实施和报告这一类系统综述面临较大挑战。此时,针对网状META分析的PRISMA扩展声明应运而生,旨在提高网状META分析系统综述的报告质量。PRISMA扩展声明是由专家们通过DELPHI调查、面对面讨论和共识大会而最终确立的。PRISMA扩展声明是在原始PRISMA声明的报告清单的基础上经过修改,最终确定了32个条目,每个条目均与网状META分析报告的内容直接相关。本文对网状META分析的PRISMA扩展声明进行了阐述,对报告清单各条目进行了举例说明,并详细说明了在原始PRISMA声明的基础上新增和修改各条目的理由。此外,PRISMA扩展声明强调了在网状META分析的实际操作中需要重点关注的信息。本文的目标读者包括网状META分析的作者与读者,以及期刊杂志的编辑与同行评审。 | 李志霞 杨俊 叶欣 周凌波 杨智荣 孙凤 詹思延 Brian Hutton Georgia Salanti Deborah M.Caldwell Anna Chaimani Christopher H.Schmid Chris Cameron John P.A.Ioannidis Sharon Straus Kristian Thorlund Jeroen P.Jansen Cynthia Mulrow Ferrán Catalá-López Peter C.Gozsche Kay Dickersin Isabelle Boutron Douglas G.Altman David Moher | 2016 | 中国循证心血管医学杂志2016，8，6： | 11 |
| 17 | Two new species of Japalura(Squamata:Agamidae)from the Hengduan Mountain Range,China显示文摘Until recently,the agamid species,Japalura flaviceps,was recognized to have the widest geographic distribution among members of the genus occurring in China,from eastern Tibet to Shaanxi Province.However,recent studies restricted the distribution of J.flaviceps to the Dadu River valley only in northwestern Sichuan Province,suggesting that records of J.flaviceps outside the Dadu River valley likely represent undescribed diversity.During two herpetofaunal surveys in 2013 and 2015,eight and 12 specimens of lizards of the genus Japalura were collected from the upper Nujiang(=Salween)Valley in eastern Tibet,China,and upper Lancang(=Mekong)Valley in northwestern Yunnan,China,respectively.These specimens display a unique suite of diagnostic morphological characters.Our robust comparisons of phenotype reveal that these populations can be distinguished readily from J.flaviceps and all other recognized congeners.Herein,we describe the two Japalura lineages as new species,Japalura laeviventris sp.nov.and Japalura iadina sp.nov..In addition,we provide updated conservation assessments for the new species as well as imperiled congeners according to the IUCN criteria for classification,discuss the importance of color patterns in the diagnosis and description of species in the genus Japalura,and discuss directions for future taxonomic studies of the group. | Kai WANG Ke JIANG Da-Hu ZOU Fang YAN Cameron D.SILER Jing CHE Kunming Institute of Zoology,Chinese Academy of Sciences Sam Noble Oklahoma Museum of Natural History and Department of Biology,University of Oklahoma Tibet University | 2016 | Zoological Research2016，37，1： | 9 |
| 18 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 19 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 20 | 睾丸核蛋白表达和基因重排在上呼吸道睾丸核蛋白中线癌中的应用显示文摘目的探讨睾丸核蛋白(NUT)抗体表达及基因重排在上呼吸道NUT中线癌(NMC)中的应用,以及NMC的发病情况、临床病理学特点、诊断及其鉴别诊断。方法收集北京同仁医院病理科1990年至2010年诊断的上呼吸道小圆细胞型恶性肿瘤163例,包括低分化鳞状细胞癌(31例)及未分化癌(1例)、非角化型未分化鼻咽癌(60例)、小细胞神经内分泌癌(6例)及其他非上皮性小圆细胞型恶性肿瘤(65例)。分析其临床特征及病理学特点,行EB病毒编码的小RNA探针(EBER)原位杂交检测及NUT单克隆抗体的免疫组织化学En Vision法染色。NUT抗体阳性表达的病例以荧光原位杂交(FISH)法检测NUT基因重排、以免疫组织化学染色方法标记角蛋白(AE1/AE3、CK7、CK8)、p63及神经内分泌标志物(神经元特异性烯醇化酶、突触素、嗜铬粒素A、S-100蛋白、CD56)。结果(1)3例低分化鳞状细胞癌及1例未分化癌中发现NUT抗体呈强阳性核表达,约占该组病例的12.5%(4/32),占本组上皮性恶性肿瘤的4.1%(4/98),全部病例的2.5%(4/163);其年龄范围为42~59岁;其他各组病例NUT抗体均为阴性;(2)4例NUT抗体阳性表达的病例其瘤细胞均表达角蛋白及p63,而神经内分泌标志物及EBER检测均阴性;(3)4例NUT阳性表达的病例中2例FISH检测证实有NUT基因重排,此2例患者死亡,另2例未检测到NUT基因重排,患者存活(分别为40及12个月)。结论(1)NMC是发生于上呼吸道的少见小圆细胞型恶性肿瘤,既往被归于低分化鳞状细胞癌及未分化癌中,其NUT抗体阳性表达及NUT基因重排阳性;(2)NMC好发于中线器官,特别是鼻腔鼻窦,与EB病毒感染无关,临床病程及预后有所不同;(3)NUT免疫组织化学染色及FISH检测在其诊断及鉴别诊断中发挥主要作用。 | 方微 Christopher A. French Michael J. Cameron 韩一丁 刘红刚 | 2012 | 中华病理学杂志2012，41，8： | 8 |
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