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| 1 | Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device显示文摘AIM: To evaluate the efficacy of circumferential endoscopic mucosal resection (EMR) with a tissue-anchoring device in comparison to forceps precut EMR and conventional endoscopic submucosal dissection (ESD). METHODS: The study was designed as a prospective, randomized, ex vivo study. Fresh ex vivo specimens were harvested from adult white Yorkshire pigs weighing 30-50 kg. Seventy-five standardized, artificial lesions measuring 3 cm × 3 cm were created by methy- lene blue tattoo at the greater curvature in fresh ex vivo stomachs using the EASIE-R simulator platform (Endosim LLC, Berlin, MA, United States). The three advanced endoscopists performed the three resection techniques such as circumferential EMR using the tissue-anchoring device (TA-EMR), forceps precut EMR (FP-EMR), and endoscopic submucosal dissection. The endoscopists and the type of cutting methods were determined randomly by grouped randomized selection.The resection bed was grossly inspected to determine whether the lesion was resected 'en-bloc ' (defined as no remaining mucosal tattoo remaining on specimen). The resection bed was also probed for evidence of perforation. The procedural time of circumferential resection, submucosal dissection, and injection frequency were recorded by an independent observer.RESULTS: All 75 created lesions were successfully resected by three advanced endoscopists using the three techniques. The mean ± SD size of resected specimens (long axis) were 39.5 ± 5.6 mm, 36.5 ± 7.3 mm, and 44.6 ± 5.6 mm for TA-EMR, FP-EMR, and ESD respectively. The overall mean dissection time of both the TA- EMR and FP-EMR was significant shorter than ESD (TA- EMR: 5.1 ± 3.3 min, FP-EMR: 3.5 ± 2.0 min vs ESD: 15.8 ± 9.5 min, P < 0.001, P < 0.001). The overall mean total procedure time of both the tissue-anchoring and forceps circumferential EMR was significantly shorter than ESD (TA-EMR: 17.5 ± 6.0 min, FP-EMR: 16.6 ± 6.6 min vs ESD: 28.6 ± 13.9 min, P < 0.001, P < 0.001). The en-bloc resection rate of ESD was 100% (25/25) and the en-bloc resection rate of the TA-EMR (84.0%, 21/25) was higher than for the FP-EMR (60.0%, 15/25), yet not statistically significant (P = 0.18). The perforation rate of each technique was 8.0% (2/25). CONCLUSION: TA-EMR appears to be quicker than ESD, and there was a trend towards improved en bloc resection rate with the TA-EMR when compared to the FP-EMR. | Yunho Jung Masayuki Kato Jongchan Lee Mark A Gromski Ram Chuttani Kai Matthes | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 3 |
| 2 | Mi- crooptical telescope compound eye 显示文摘 | DUPARRE J SCHREIBER P MATTHES A | | Optics Express0，13，3： | 1 |
| 3 | Coparison of beta-thrombothlobulin,flow cytometry,and platelet aggrego-metry to study platelet activation显示文摘 | Matzdorff A C Matthes K B Voss R | 1996 | Haemostasis1996，26，2： | 1 |
| 4 | The semaphorin genes en?code a family of transmembrane and secreted growth cone guidance molecules显示文摘 | Kolodkin A L Matthes D J Goodman C S | 1993 | Cell1993，75，7： | 1 |
| 5 | Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy-and 5-methyl-β-L-deoxycytidine analogues显示文摘 | MATTHES E FUNK A KRAHN I | 2007 | Antimicrob Agents Chemother2007，51，7： | 1 |
| 6 | Are performance indicators generic? The international experience of the Quality Indicator Project 显示文摘 | Kazandjian V A Matthes N Wicker K G | 2003 | Journal of Evaluation in Clinical Practice2003，，5： | 1 |
| 7 | Physical activity and its influence on the repair process of medial collateral ligaments 显示文摘 | Vailas A C Tipton C M Matthes R D | 1981 | Connect Tissue Res1981，，9： | 1 |
| 8 | Quantitative autoradiography of adenosine receptors and NBTI - sensitive adenosine transporters in the brains and spinal cords of mice deficient in the opioid receptor gene 显示文摘 | Bailey A Matthes H Kieffer B | 2002 | Brain Res2002，943，1： | 1 |
| 9 | Protein Z influences prothrornbotic phenotype of factor V leiden in humans显示文摘 | Kemkes-Matthes B Matzdorff A Matthes KJ | 2000 | Blood2000，96，： | 1 |
| 10 | The semaphorin genes encode a family of transmembrane and secreted growth cone guid- ance molecules显示文摘 | Kolodkin A L Matthes D J Goodman C S | 1993 | Cell1993，75，7： | 1 |
| 11 | N-e-fructosyllysineand N-e-carboxymethyllysine, but not lysinoalanine,are a-vailable for absorption after simulated gastrointestinal diges-tion显示文摘 | Hellwig M Matthes R Peto A | 2014 | Amino Adds2014，46，： | 1 |
| 12 | , Microoptical Telescope Compound Eye 显示文摘 | Duparr6 J Schreiber P Matthes A | 2005 | Opt Express2005，713，3： | 1 |
| 13 | Effects of hemoconcentration and sympathetic activation on serum lipid response to brief mental stress显示文摘 | ELIZABETH A B MATTEW F M KAREN A MATTHE WS | 2002 | Psycho-somatic Medicine2002，64，： | 1 |
| 14 | Lack of reward and locomotor stimulation induced by heroin in micro-opioid receptor-deficient mice 显示文摘 | Contarino A Picetti R Matthes HW Koob GF Kieffer BL Gold LH | 2002 | Eur J Pharmacol2002，446，3： | 1 |
| 15 | Amplifying the pacific climate system response to a small 11-year solar cycle forcing显示文摘 | Meehl G A Arblaster J M Matthes K | 2009 | Science2009，325，： | 1 |
| 16 | Influence of prolonged adaptation periods on starch degradation in the digestive tract of dairy cows显示文摘 | Matthe A Lebzien P Hric I Flachowsky G | 2003 | Anim Feed Sci Technol2003，103，： | 1 |
| 17 | One-pot synthesis of symmetrical and unsymmetrical bisarylethynes by a modification of the sonogashira coupling reaction显示文摘 | Matthe W M Paul A G | | 0，，19： | 1 |
| 18 | Electron spin resonance spectroscopy of serum albumin: a novel new test for cancer diagnosis and monitoring显示文摘 | Kazmierczak SC Gurachevsky A Matthes G | 2006 | Clin Chem2006，52，： | 1 |
| 19 | Disease specific al- bumin patterns defined by electron spin resonance显示文摘 | Muravsky V Gurachevsky A Matthes G | 2007 | Tumor Biol2007，28，： | 1 |
| 20 | Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations显示文摘 | Hayes A F Matthes J | 2009 | Behavior Research Methods2009，41，3： | 1 |
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