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| 1 | Mitochondrial protection by low doses of insulin-like growth factor-Ⅰin experimental cirrhosis显示文摘AIM: To characterize the mitochondrial dysfunction in experimental cirrhosis and to study whether insulin-like growth factor-Ⅰ(IGF-Ⅰ) therapy (4 wk) is able to induce beneficial effects on damaged mitochondria leading to cellular protection. METHODS: Wistar rats were divided into three groups: Control group, untreated cirrhotic rats and cirrhotic rats treated with IGF-Ⅰtreatment (2 μg/100 g bw/d). Mitochondrial function was analyzed by flow cytometry in isolated hepatic mitochondria, caspase 3 activation was assessed by Western blot and apoptosis by TUNEL in the three experimental groups. RESULTS: Untreated cirrhotic rats showed a mitochon- drial dysfunction characterized by a significant reduction of mitochondrial membrane potential (in status 4 and 3); an increase of intramitochondrial reactive oxigen species (ROS) generation and a significant reduction of ATPase activity. IGF-Ⅰtherapy normalized mitochondrial func-tion by increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radical production. Activity of the electron transport complexes Ⅰand Ⅲ was increased in both cirrhotic groups. In addition, untreated cirrhotic rats showed an increase of caspase 3 activation and apoptosis. IGF-Ⅰtherapy reduced the expression of the active peptide of caspase 3 and resulted in reduced apoptosis. | Raquel Pérez María García-Fernández Matías Díaz-Sánchez Juan E Puche Gloria Delgado Marian Conchillo Jordi Muntané Inma Castilla-Cortázar | 2008 | World Journal of Gastroenterology2008，14，17： | 11 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Emergence of novel strains of avian infectious bronchitis virus in Sweden显示文摘 | Shahid Hussain Abro Lena H.M. Renstr?m Karin Ullman Mats Isaksson Siamak Zohari Désirée S. Jansson Sándor Belák Claudia Baule | 2011 | Veterinary Microbiology (-)2011，，2： | 2 |
| 4 | Mesoscopic scale analysis of the reaction-bonded SiC process显示文摘 | ILEGBUSI O J YANG J J Mat M D | 1999 | Compos Part A Appl Sci Manuf1999，30，3： | 1 |
| 5 | Taylor-Vaisey A:Impact of formal continuing medical education-Do conferences,work shops,rounds,and other traditional continuing education activities change physician behavior or health care outcomes?显示文摘 | Davis D O'Brien MAT Fseemantle N | 1999 | Jama-Joumal of the American Medical Association1999，282，9： | 1 |
| 6 | Development and testing of a highly efficient proton exchange membrane(PEM)electrolyzer stack显示文摘 | SELAMET O F BECERIKLI F MAT M D | 2011 | International Journal of Hydrogen Energy2011，36，11： | 1 |
| 7 | Application of a hybrid model of mushy zone to macrosegregation in al loy solidification 显示文摘 | MAHMUT D MAT Olusegun J Ilegbusi | 2002 | International Journal of Heat and Mass Transfer2002，45，： | 1 |
| 8 | Water Management in a Single Cell Proton Exchange Membrane Fuel Cells with a Serpentine Flow Field 显示文摘 | MAT H N S WAN D W R KAMARUZZAMAN S | 2009 | Journal of Power Sources2009，193，1： | 1 |
| 9 | Regions of the genome that affect grain and malt quality in a North American two- row barley cross显示文摘 | Mat her D Tinker N LaBerge D et a l | 1997 | Crop Science1997，37，2： | 1 |
| 10 | Generalized evaluation in decision analysis 显示文摘 | MATS D | 2005 | European Journal of Operational Research2005，162，7： | 1 |
| 11 | Sparse recon-struction by separable approximation 显示文摘 | Wright S J Nowak R D Figueiredo MAT | 2009 | IEEE Transactionson Signal Processing2009，57，7： | 1 |
| 12 | Chronic myocardial infarction in the mouse:cardiac structural and functional changes显示文摘 | Esther L Mat J Ebo D | 1999 | Cardiovasc Res1999，41，： | 1 |
| 13 | Gradient projection for sparse reconstruction ; application to compressed sensingand other inverse problems 显示文摘 | Figueiredo MAT Nowak R D Wright S J | 2007 | Journal of Selected Topics in Signal Processing : Special Issue on Convex Optimization Meth-ods for Signal Processing2007，1，4： | 1 |
| 14 | Biosorption of cop- per( Ⅱ ) onto immobilized cells of Pycnoporus sanguineus from aqueous solution: equilibrium and kinetic studies显示文摘 | YAHAYA Y A MAT D M BHATIA S | 2009 | Journal of Hazardous Materials2009，161，1： | 1 |
| 15 | An EM algorithm for wavelet-based image restoration显示文摘 | Figueiredo MAT Nowak R D | 2003 | IEEE Trans Image Process2003，12，： | 1 |
| 16 | Stroke in young people显示文摘 | Díaz-Marín C Matías-Guiu J | 1996 | Rev Neu-rol1996，24，126： | 1 |
| 17 | Stationary vortices attached on flat roofs 显示文摘 | Tryggeson Henrik Lyberg Mats D | 2010 | Journal of Wind Engineering and Industrial Aerodynamics2010，98，1： | 1 |
| 18 | Processing of discard refrigerators in netherland显示文摘 | Mat L M Alfred J D | 1998 | Technology1998，18，2： | 1 |
| 19 | Dual-source CT coronary angiography:image quality,mean heart rate,and heart rate variability显示文摘 | Mat D Scheffel H Leschka S | | 0，，： | 1 |
| 20 | A three dimensional mathematical model for absorption in a metal hydride bed 显示文摘 | Aldas Kemal Mat M D Yuksel Kaplan | 2002 | Int J Hydrogen Energy2002，27，10： | 1 |
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