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	题名	作者	年代	出处	被引量
1	Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies.	Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila	2010	World Journal of Gastroenterology2010，16，25：	2
2	Wavelet-based histograms for selectivity estimation 显示文摘	Matias Y Vitter J S Wang M	1998	ACM SIGMOD Record1998，27，2：	1
3	Expression of tolerance for Meloidogyne graminicola in rice euhivars as affected by soil type and flooding显示文摘	Soriano I R S Prot J C Matias D M	2000	Journal of nematology2000，，32：	1
4	Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘	Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R	1996	Plant Cell1996，8，：	1
5	Wnt signaling in polycystic kidney disease显示文摘	Thomas B Matias S Gerd W	2007	J Am Soc Nephrol2007，18，：	1
6	Thermal conffort criteria and building design: Field work in Portugal 显示文摘	Manuel Correia Guedes Lul's Matias Carlos Pina Santos	2009	Renewable Energy2009，34，11：	1
7	Phytoplankton succession in intensive marine shrimp culture ponds treated with a commercial bacterial product 显示文摘	Yusoff F M Zubaidah M S Matias H B	2002	Aquac Res2002，33，4：	1
8	Microstructural and electrical properties of sintered tungsten trioxide显示文摘	Filho S A G Matias J G N Dias N L	1999	Journal of Material Science1999，34，：	1
9	A corporative memory based on the user profiles显示文摘	Matias A Manuel R S Leonid S	2004	Expert Systems with Applications2004，26，1：	1
10	Wavelet-based histograms for selectivity estimation 显示文摘	MATIAS Y VITTER J S WANG M	1998	ACM SIGMOD Record1998，27，2：	1
11	Effects of a Variable Delay in Delayed Dynamical Systems显示文摘	Madruga S Boccaletti S Matias M	2001	Int J of Bifurcation and Chaos2001，11，11：	1
12	Differential diagnosis of mesiotemporal lesions:case report ofneurosyphilis 显示文摘	Vieira Santos A Matias S Samiva P	2005	Neuroradiology2005，47，9：	1
13	Differential Diagnosis of Siotemporal Lesions: Case Report of Neurosyphilis 显示文摘	Santos VA Matias S Saraiva P	2005	Neuroradiology (S0028-3940)2005，47，9：	1
14	Angiographic evaluation and embolization of cervico-cranial tumors-juvenile paraganglioma and angiofibroma of the nasopharynx显示文摘	Matias S Vilela P Goulao A		0，，03：	1
15	显示文摘	Filho A G S Matias J G N Dias N L	1999	J Mater Sci1999，34，：	1
16	Differential Diagnosis of Siotemporal Lesions: Case Report of Neurosyphilis显示文摘	SANTOS VA MATIAS S SARAIVA P	2005	Neuroradiology(S0028-3940)2005，47，9：	1
17	Nitrogen compounds and soluble sugars in tissues of organic,hydroponic,and conventional lettuce显示文摘	Cometti N N Matias G C S Zonta E	2004	Horticultura Brasileira2004，22，4：	1
18	Diferential diagnosis of me siotemporal lesions: case report of neurosyphilis显示文摘	Vieira Santos A Matias S Saraiva P	2005	Neuroradi- ology2005，47，：	1
19	Dysregulation of pe- ripheral endocannabinoid levels in hyperglycemia and obesity: effect of high fat diets显示文摘	Matias I Petrosino S Racioppi A	2008	Mol Cell Endocrinol2008，286，121：	1
20	Antimicrobial plant extracts encapsulated into polymeric beads for potential ap- plication on the skin显示文摘	RIJO P MATIAS D FERNANDES A S	2014	Polymers2014，6，2：	1

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