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| 1 | Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4显示文摘Objective:To investigate the cytotoxic activity of endophytic fungi isolated from mangrove fungi.Methods:In the present study the DNA was isolated and the ITS region of 5.8s rRNA was amplified using specific primers ITS 1 and ITS4 and sequence was determined using automated sequencers.Blast search sequence similarity was found against the existing non redundant nucleotide sequence database thus,identified as Aspergilus flavus,Hyporcaea lixii,Aspergillus niger,Eutorium amstelodami,Irpex hydnoides and Neurospora crassa.Among the seven isolates, one fungi Irpex hydnoides was selected for further studies.The fungi were grown in sabouraud broth for five days and filtrate were separated and subjected to ethyl acetate for further studies. Results:Nearly half(49.25%) of the extracts showed activity(IC_(50) of 125 μ g/mL).These values were within the cutoff point of the National Cancer Institute criteria for cytotoxicity(IC_(50)<20 μ g/mL) in the screening of crude plant extracts.The GC MS analysis revealed that the active principals might be Tetradecane(6.26%) with the RT 8.606.Conclusions:It is clear from the present study that mangrove fungi with bioactive metabolites can be expected to provide high quality biological material for high throughout biochemical,anti cancer screening programmes.The results help us conclude that me potential of using metabolic engineering and post genomic approaches to isolate more novel bioactive compounds and to make their possible commercial application is not far off. | B Valentin Bhimba DA Agnel Defora Franco Geena Mary Jose Jibi Merin Mathew Elsa Lycias Joel | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 2 | Inhibitory kappa B kinase 2 activates airway epithelial cells to stimulate bone marrow macrophages 显示文摘 | MATHEW B PARK GY CAO H | 2007 | Am J Respir Cell Mol Biol2007，36，5： | 1 |
| 3 | A 4GHz 300mW 64b integer execution ALU with dual supply voltages in 90nm C MOS 显示文摘 | Mathew S K Anders M A Bloechel B etal | 2005 | IEEE Journal of Solid - State Circuits2005，40，1： | 1 |
| 4 | Phosphorus in Hawaiian Kikuyugrass Pastures and Potential Phosphorus Release to Water显示文摘 | Mathews B W Carpenter J R Sollenberger L E | 2005 | Journal of Environmental Quality2005，，4： | 1 |
| 5 | 查看详情显示文摘 | Leong W L Mathews N Tan B Vaidyanathan S Dotz F Mhaisalkar S | | 0，，： | 1 |
| 6 | Parametric study on the combined thermal and hydraulic performance of single phase micro pin-fin heat sinks part I: Square and circle geometries 显示文摘 | JOHN T J MATHEW B HEGAB H | 2010 | International Journal of Thermal Sciences2010，49，11： | 1 |
| 7 | Endoscopy assisted percutaneous anterior interbody fusion with subcutaneous suprafascial internal fixation: evolution of technique and surgical considerations 显示文摘 | Mathews H H Long B H | 1995 | Orthop Int ED1995，3，： | 1 |
| 8 | Autophagy suppresses tumorigenesis through elimination of p62显示文摘 | Mathew R Karp C M Beaudoin B | 2009 | Cell2009，137，6： | 1 |
| 9 | Wind and water erosion and transport in semi-arid shrubland,grassland and forest ecosystems:quantifying dominance of horizontal wind-driven transport显示文摘 | David D B Jeffrey J W Mathew P J | 2003 | Earth Surface Processes and Landforms2003，28，： | 1 |
| 10 | Single-agent arsenic trioxide in the treatment of newly diagnosed aeute myelocytic leukemia:dura-ble remissins with minimal toxicity显示文摘 | Mathews V George B Lakshmi KM | 2006 | {H}Blood2006，，： | 1 |
| 11 | Autophagy promotes tumor cell survival and restricts necrosis,inflammation,and tumorigenesis显示文摘 | Degenhardt K Mathew R Beaudoin B | | 0，，01： | 1 |
| 12 | Single-agent Arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia:long-term follow-up data显示文摘 | Mathews V George B Chendamarai E | | 0，，24： | 1 |
| 13 | The mitochondrial car- diolipin remodeling enzyme lysocardiolipin acyltransferase (LYCAT) is a novel target in pulmonary fibrosis显示文摘 | Huang L Mathew B Li H | 2014 | Am J Respir Crit Care Med2014，189，11： | 1 |
| 14 | Deter- mining embedding dimension for phase-space recon- struction using a geometrical construction显示文摘 | Kennel Mathew B Brown R Abarbanel H D I | 1992 | Phy Rev A1992，45，： | 1 |
| 15 | Application of the indicators of hydrologic alteration software in environmental flow setting 显示文摘 | Mathews R Richter B D | 2007 | Journal of American Water Resources Association2007，43，6： | 1 |
| 16 | An investigation of the high speed machining process using a variable flow stress machining theory显示文摘 | ARSECULARATNE J A KRISTYANTO B MATHEW P | 2004 | Machining Science and Technology2004，8，2： | 1 |
| 17 | Evaluation of Chemoprevention of oral cancer with spirulina fusiformis显示文摘 | Mathew B Sankaranarayanan R | 1995 | Nutr and cancer1995，24，2： | 1 |
| 18 | Triptolide simultaneously inducesreactive oxygen species, inhibits NF-kappaB activity and sensitizes5-fluorouracil in colorectal cancer cell lines 显示文摘 | Xu B Guo X Mathew S | 2010 | Cancer Lett2010，291，2： | 1 |
| 19 | Stem cell based treatments for Type I diabetes mellitus: bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells显示文摘 | Godfrey KJ Mathew B BulmanJC | 2012 | Diabet Med2012，29，1： | 1 |
| 20 | The use of procalcitonin as a marker of sepsis in children显示文摘 | Mathew B Roy DD Kumar TV | 2013 | J Clin Diagn Res2013，7，2： | 1 |
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