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| 1 | Hematological disorders and pulmonary hypertension显示文摘Pulmonary hypertension(PH),a serious disorder with a high morbidity and mortality rate,is known to occur in a number of unrelated systemic diseases.Several hematological disorders such as sickle cell disease,thalassemia and myeloproliferative diseases develop PH which worsens the prognosis.Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction.Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity,activation of proliferative and antiapoptotic pathways leading to vascular remodeling,elevated pulmonary artery pressure,right ventricular hypertrophy and premature death.Hemolysis observed in hematological disorders leads to free hemoglobin which rapidly scavenges nitric oxide(NO),limiting its bioavailability,and leading to endothelial dysfunction.In addition,hemolysis releases arginase into the circulation which converts L-arginine to ornithine,thus bypassing NO production.Furthermore,treatments for hematological disorders such as immunosuppressive therapy,splenectomy,bone marrow transplantation,and radiation have been shown to contribute to the development of PH.Recent studies have shown deregulated iron homeostasis in patients with cardiopulmonary diseases including pulmonary arterial hypertension(PAH).Several studies have reported low iron levels in patients with idiopathic PAH,and iron deficiency is an important risk factor.This article reviews PH associated with hematological disorders and its mechanism:and iron homeostasis and its relevance to PH. | Rajamma Mathew Jing Huang Joseph M Wu John T Fallon Michael H Gewitz | 2016 | World Journal of Cardiology2016，8，12： | 6 |
| 2 | 性传播疾病的性伴通知策略显示文摘 | Mathews C Coetzee N Zwarenstein M Lombard C Guttmacher S Oxman A Schmid G 刘善民 | 2005 | 生殖与避孕2005，25，6： | 5 |
| 3 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 4 | Hepatitis C virus and neurological damage显示文摘Chronic hepatitis C virus(HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and HCV replication in neurons is another factor that severely affects the nervous system. Furthermore, HCV infection causes both sensory and motor peripheral neuropathy in the mixed cryoglobulinemia as well as known as an important risk aspect for stroke. These extrahepatic manifestations are the reason behind underlying hepatic encephalopathy and chronic liver disease. The brain is an apt location for HCV replication, where the HCV virus may directly wield neurotoxicity. Other mechanisms that takes place by chronic HCV infection due the pathogenesis of neuropsychiatric disorders includes derangement of metabolic pathways of infected cells, autoimmune disorders, systemic or cerebral inflammation and alterations in neurotransmitter circuits. HCV and its pathogenic role is suggested by enhancement of psychiatric and neurological symptoms in patients attaining a sustained virologic response followed by treatment with interferon; however, further studies are required to fully assess the impact of HCV infection and its specific antiviral targets associated with neuropsychiatric disorders. | shilu mathew muhammed faheem sara m ibrahim waqas iqbal bisma rauff kaneez fatima ishtiaq qadri | 2016 | World Journal of Hepatology2016，8，12： | 3 |
| 5 | Observation of Bose - Einstein condensation in a dilute atomic vapor显示文摘 | ANDERSON M H ENSHER J R MATHEWS M R | 1995 | Science1995，269，5221： | 2 |
| 6 | Molecular targets in the treatment of anxiety显示文摘 | Kent J M Mathew S J Gorman J M | 2002 | Biol Psychiatry2002，52，10： | 2 |
| 7 | Effect of corn moisture on the properties of pet food extrudates 显示文摘 | Hoseney R C Faubion J M | 1999 | Cereal Chemistry1999，76，6： | 1 |
| 8 | Fertility preservation in young women with epithelial ovarian cancer 显示文摘 | Wright JD Shah M Mathew L | 2009 | Cancer2009，115，18： | 1 |
| 9 | A 4GHz 300mW 64b integer execution ALU with dual supply voltages in 90nm C MOS 显示文摘 | Mathew S K Anders M A Bloechel B etal | 2005 | IEEE Journal of Solid - State Circuits2005，40，1： | 1 |
| 10 | 显示文摘 | Mathews T Manoravi P Antony M P | 2000 | Solid State Ionics2000，135，： | 1 |
| 11 | Continuous-mixtures vapor-liquid equilibria computations based on true boiling point distillations 显示文摘 | HAYNES H W MATHEWS M A | 1991 | Ind Eng Chem Res1991，30，： | 1 |
| 12 | Synthesis, phase transition and thermal expansion studies on M2 MgWO6 ( M -: Ba^2+ and Sr^2+ ) double perovskites显示文摘 | Patwe S J Achary S N Mathews M D | 2005 | Journal of Alloys and Compounds2005，390，12： | 1 |
| 13 | Multiple type-B re-sponse regulators mediate cytokinin signal transduction in Arabidopsis显示文摘 | MASON M G MATHEWS D E ARGYROS D A | 2005 | Plant Cell2005，17，： | 1 |
| 14 | Uhrasound guided vacuumassisted excision in the diagnosis and treatment of clinically benign breast lesions显示文摘 | Mathew J Crawford D J Lwin M | 2007 | Ann R Coll Surg Engl2007，5，4： | 1 |
| 15 | The effect of morphology and chemical characteristics of cellulose reinforcements on the crystallinity of polylactic acid显示文摘 | MATHEW A P OKSMAN K SAIN M | | 0，，1： | 1 |
| 16 | Characterization of the interlaminar fracture toughness of a laminated carbon/epoxy composite显示文摘 | Mathews M J Swanson S R | 2007 | Compos Sci Technol2007，67，： | 1 |
| 17 | Excretion of Phosphate and Soluble Organic Phosphorous Compounds by Zooplankton 显示文摘 | POMEROY L R MATHEWS H M MIN H S | 1963 | Limnol Oceanogr1963，，8： | 1 |
| 18 | Posterior vitreous detachment following cataract surgery显示文摘 | Hilford D Hilford M Mathew A | 2009 | Eye2009，23，6： | 1 |
| 19 | Autophagy suppresses tumorigenesis through elimination of p62显示文摘 | Mathew R Karp C M Beaudoin B | 2009 | Cell2009，137，6： | 1 |
| 20 | National innovative capacity in East Asia显示文摘 | HU M Mathews J A | 2005 | Research Policy2005，34，9： | 1 |
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