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| 1 | 结缔组织病相关的间质性肺疾病的管理显示文摘肺是系统性结缔组织病(CTD)并发症的常见部位,肺部表现可以多种形式存在。间质性肺疾病(ILD)和肺高压(PH)是CTD中最常见的肺部表现。虽然普遍认为ILD发生在CTD之后,但它往往是CTD的最初表现(“肺主导”型CTD)。ILD可以存在于大多数类型的CTD中,包括类风湿关节炎、硬皮病、系统性红斑狼疮、多发性肌炎或皮肌炎、干燥综合征和混合性结缔组织病。尽管CTD相关的ILD(CTD-ILD)与其他形式的ILD有着相似的临床和病理表现,但CTD—ILD的预后和治疗却与其他的ILD(如特发性肺纤维化)有着极大的差异。PH可作为肺动脉高压的主要血管病变或与ILD相关(PH—ILD)。因此,需要详细的病史、体格检查、特定的血清学检测,偶尔还需肺活检,来诊断CTD-ILD。然而,PH的诊断需借助于非侵入性和(或)侵入性方法来评估肺血流动力学。尽管尚缺乏随机对照试验支持的ILD特异性治疗证据,但免疫抑制是ILD治疗的支柱。此外,治疗策略根据临床情况的不同而变化。例如,新诊断的CTD-ILD患者与急性加重的患者的治疗方案不同。免疫抑制剂仅在CTD-PH的特定病例中有所推荐,更常见的是使用选择性肺血管扩张剂。对于这两种疾病,应该评估和治疗诸如睡眠呼吸障碍、呼吸困难和咳嗽等并发症。疾病晚期的患者应考虑肺移植,但由于CTD和其他合并症,肺移植也并非总是可行的。故需要开展免疫抑制治疗等新型治疗方法的,临床试验,来提供最佳的治疗策略。 | Stephen C Mathai 罗萨 代华平 | 2017 | 英国医学杂志中文版2017，20，6： | 2 |
| 2 | Risk factors for endophthalmitis following cataract surgery-our experience at a tertiary eye care centre in India显示文摘AIM: To determine the risk factors for acute endophthalmitis after cataract extraction in a tertiary care centre in India.·METHODS: We performed a nested case control study within a retrospective cohort. The surgical records of all patients with clinically diagnosed endophthalmitis within one month after cataract surgery, performed between January 2006 and December 2009, were reviewed. These were compared with randomly selected age and gender-matched controls, from patients having routine cataract surgery within ±1wk of the endophthalmitis case.Univariable and multivariable analysis were performed to identify risk factors for endophthalmitis.· RESULTS: Of the total 33 856 cataract surgeries performed during this period, there were 57 cases of postoperative acute endophthalmitis that met our study criteria. Thus, the overall incidence of endophthalmitis in our cohort was 1.6 per 1000 cataract extractions performed. Mean age of cases was 55.9y(SD: 10.9y) and for controls was 55.6y(SD: 9.8y). Thirty-five cases(61.4%)and 133 controls(59.6%) were males. Median time of onset of endophthalmitis was 4d(IQR 2-9d; range: 1-30d).Thirty-nine cases(68.4%) presented within 7d and 27 cases(47.4%) were culture positive. Two hundred and twenty-three age and gender matched controls were selected. In multivariate analysis, endophthalmitis was associated with posterior capsular rupture(PCR) during surgery(OR 6.98, 95%CI: 2.22-21.98), phacoemulsification via scleral incision with a foldable intraocular lens(IOL)implantation(OR 3.02, 95%CI: 1.13-8.04) and ocular comorbidity(OR 2.32, 95%CI: 1.11-4.87).·CONCLUSION: PCR, presence of ocular co-morbidity,and phacoemulsification via scleral incision with foldable-IOL were found to be independent risk factors for acute endophthalmitis. | Rohit C.Khanna Vanita Pathak Ray Madhavi Latha Sandra D Cassard Annie Mathai Garudadri C Sekhar | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 2 |
| 3 | Post-exposure prophylaxis for blood borne viral infections in healthcare workers显示文摘 | Varghese G M Abraham O C Mathai D | 2003 | Postgrad Med J2003，79，932： | 1 |
| 4 | Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group 显示文摘 | Mathay MA Zimmerman A Esmon C | 2003 | Am J Respir Crit Care Med2003，167，7： | 1 |
| 5 | Recombinant activated factor VII (rFV 11 a) in the management of major obstetric haemorrhage: A case series and a proposed guideline for use 显示文摘 | Bomken C Mathai S Biss T | 2009 | Obstetrics and Gynecology International2009，2009，36： | 1 |
| 6 | Predictors of multi-organ dysfunction in heatstroke 显示文摘 | G M Varghese G John K Thomas O C Abraham D Mathai | 2005 | Emerg Med J2005，22，： | 1 |
| 7 | Mechanism of electrical conduction in plasma polymerized furfural thin films 显示文摘 | Joseph Mathai C Anantharaman M R Venkitachalam S | 2002 | Thin Solid Films2002，416，12： | 1 |
| 8 | Detection of heat stable mycobacterial antigen in cerebrospinal fluid by Dot Immunobinding assay显示文摘 | MATHAI A RADHAKRISHNAN VV SARADA C | | 0，，01： | 1 |
| 9 | Tricuspid annular displacement predicts survival in pulmonary hypertension显示文摘 | FORFIA P R FISHER M R MATHAI S C | 2006 | Am J Respir Crit Care Med2006，174，： | 1 |
| 10 | Nutritional value of dried fermentation biomass ,hydrolyzed porcine in- testinal mucosa products, and fish meal fed to wean- ling pigs 显示文摘 | Sulabo R C Mathai J K Usry J L | 2013 | Journal of Animal Science2013，，91： | 1 |
| 11 | Regulation of apoptosis by endoplasmic reticulum pathways显示文摘 | Breckenridge D G Germain M Mathai J P Nguyen M Shore G C | 2003 | Oncogene2003，22，53： | 1 |
| 12 | Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases : Impact of interstitial lung disease 显示文摘 | MATHAI S C HUMMERS L K CHAMPION H C | 2009 | Arthritis Rheum2009，60，2： | 1 |
| 13 | Role of nutrient elements and their deficiency symptons with reference to arecanut 显示文摘 | Yadav R B R Mathai C K Vellaichami K | 1972 | Arecanut and spices Bull1972，3，： | 1 |
| 14 | Detection of Heat Stable Mycobacterial Antigen in Cerebrospi nal fluid by Dot Immunobinding Assay显示文摘 | MATHAI A RADHAKRISHNAN VV SARADA C | 2003 | Neurol India(S0028-3886)2003，51，1： | 1 |
| 15 | Receptor models in air resources management: a summary of the APCA international specialty conference 显示文摘 | WATSON J CHOW J MATHAI C | 1989 | Journal Air Waste Management1989，39，4： | 1 |
| 16 | The pattern of rhizome yield and their accumulation of commercially important chemical constituents in turmeric (Curcuma species),during growth and development显示文摘 | Mathai C K | 1978 | Qualitas Plantarum1978，28，3： | 1 |
| 17 | Tricuspid annular displacement predicts survival in pulmonary hypertension显示文摘 | FORFIA P R FISHER M R MATHAI S C | 2006 | Am J Respir Crit Care Med2006，174，9： | 1 |
| 18 | BH3-only BIK regulates BAX,BAK de-pendent release of Ca2+ from endoplasmic reticulum stores and mitochondrial apoptosis during stress-induced cell death显示文摘 | Mathai J P Germain M Shore G C | 2005 | Biol Chem2005，280，23： | 1 |
| 19 | Post- exposure prophylaxis for blood borne viral infections in healthcare workers显示文摘 | VARGHESE G M ABRAHAM O C MATHAI D | 2003 | Postgrad Med J2003，79，： | 1 |
| 20 | Productivity of black pepper vines as influenced by the light availability during preflowering stage显示文摘 | Mathai C K Sastry K S K | 1988 | Comparative Physiology and Ecology1988，13，： | 1 |
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