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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy显示文摘瞄准:为在活体内评估一根最新发达的手持的共焦的探针在啮齿类动物的完全的胃肠道的显微镜的成像。方法:一根新奇僵硬共焦的探针(直径 7 公里) 为 fluorophore 刺激用 488 nm 单身者线激光在人为使用与类似于灵活 endomicroscopy 系统的光特征被设计。轻排放在 505 ~ 750 nm 被检测。看法的地多样地是 475 妈妈 475 妈妈。光片厚度是有 0.7 妈妈的侧面的分辨率的 7 妈妈。在不同深度(到 250 妈妈的表面) 的表面下的连续图象多样地在 1024 点在实时被产生由在轻轻的、稳定的接触把探查放到织物上的 1024 个象素(0.8 frames/s ) 。织物标本为组织病理学说的关联被取样。结果:食管,胃,小并且大肠和中央,肝,胰和胆囊是在在 n = 的高分辨率的视觉 ised 在活体内 48 个鼠标。有共焦的微型显微镜学探查的实时显微镜的成像是容易的完成。不同染色协议(荧光黄,吖啶黄,标记 FITC 的葡聚糖和 L。可食用嗯植物凝血素) 织物的每个加亮的特定的方面,和在活体内成像与常规组织学最优地相关。在活体内血流监视把功能的质量加到词法成像。结论:共焦的显微镜学是在甚至表面下的织物结构的高分辨率允许完全的官方补给的道的可视化的可行在活体内。在这研究评估的新共焦的探查设计与腹腔镜检查兼容并且显著地扩展可能的应用的地到 intra 腹的机关。它允许新在活体内染色和申请选择的立即的测试因此在病人从动物研究允许快速的转移到临床的使用。 | Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 3 | 烤烟,白肋烟和香料烟(Nicotiana tabacum)烟叶中镉浓度的调查显示文摘 | LLUGON-MOULIN N MARTIN F KRAUSS M R RAMEY P B ROSSIL 吴晓芸(译) 康婧(校) | 2006 | 中国烟草学报2006，12，6： | 3 |
| 4 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 5 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 6 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 7 | 热浸镀锌超高强钢板钒微合金化技术研究显示文摘对超高强度钢板进行热处理,模拟热浸镀锌和合金化镀锌工艺的热循环,并考察获得的力学性能和微观组织。研究用钢含有适量的碳(~0.2%)、锰(1.2%)和铬(0.4%),保证钢板在奥氏体化后在镀锌前的连续退火线上进行快速冷却时能够完全转变成马氏体。采用不同的钒含量(0~0.1%)和氮含量(0.002%~0.012%),研究这些微合金化元素对回火马氏体强度的影响。尤其与高氮相配合情况下,钒有助于抵抗回火效应,因此在镀锌后大部分原始强化贡献被保留下来,使得钢的抗拉强度超过1 000 MPa。使用铝或硅进行不同脱氧试验,发现在同一碳含量下两者具有相同的强度水平,但是Si镇静钢的弯曲性能明显优异。对退火钢板进行微观组织观察,但是钒产生有益作用的原因还未完全掌握。通过研究得出这样结论:钒微合金化对耐腐蚀超高强度钢板的开发而言是一种极具前景的途径。 | Hutchinson B Martin D Karlsson O Lindberg F Thoors H Marceau R K W Taylor A S | 2016 | 钢铁钒钛2016，37，6： | 2 |
| 8 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 9 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography显示文摘 | Stephen Schroeder Andreas F Kopp Axel Kuettner Christof Burgstahler Christian Herdeg Martin Heuschmid Andreas Baumbach Claus D Claussen Karl R Karsch Ludger Seipel | 2002 | Clinical Imaging2002，，2： | 2 |
| 10 | Detection and classification of vehicle显示文摘 | GUPTES MASOUDO MARTIN R F K | 2002 | IEEE Transactions on Intelligent Transportation2002，3，1： | 1 |
| 11 | Base-pair neutral homozygotes can be discriminated by calibrated high-resolution melting of small amplicons显示文摘 | Gundry C N Dobrowolski S F Martin Y R | 2008 | Nucleic Acids Res2008，36，： | 1 |
| 12 | Leak detection and calibration using transients and genetic algorithms显示文摘 | Vitkovsky J P Simpson A R Martin F L | 2000 | Journal Water Resource Planning and Management2000，126，4： | 1 |
| 13 | Detection and Classification of Vehicles显示文摘 | GUPTE S MASOUD 0 MARTIN R F K | 2002 | IEEE Transactions on Intelligent Transportation Systems2002，3，1： | 1 |
| 14 | Necrotizing lymphadenitis: a study of 30cases显示文摘 | Tumer R R Martin J Dorfman R F | 1983 | Am J Surg Pathol1983，7，： | 1 |
| 15 | 显示文摘 | MARTIN P D JONES G R STRINGER F WILSON I D | 2003 | Analyst2003，128，： | 1 |
| 16 | Hepatic resection in localized Caroli disease显示文摘 | Espinoza R San Martin S Court F | 2003 | Rev Med Chil2003，131，2： | 1 |
| 17 | Community attachment and attitudes toward tourism development显示文摘 | McCool S F Martin S R | 1994 | Journal of Travel Research1994，32，3： | 1 |
| 18 | Platelet glycoprotein Ⅱb/Ⅲa and size are incresed in acute myocardial infarction显示文摘 | GILES H SMITH R E MARTIN J F | | 0，，： | 1 |
| 19 | Effect of successive watermelon plantings on Fusarium oxysporum and other microorganisms in soils suppressive and conducive to Fusarium wilt of watermelon 显示文摘 | Larkin R Hopkins D Martin F | 1993 | Phytopathology1993，83，10： | 1 |
| 20 | Nontreponemal tests in the diagnosis of neurosyphilis: an evaluation of the Venereal Disease Research Laboratory (VDRL) and the Rapid Plasma Reagin (RPR) tests显示文摘 | Castro R Prieto ES da Luz Martins Pereira F | 2008 | J Clin Lab Anal2008，22，4： | 1 |
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