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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Chronic hepatitis C is a common associated with hepatic granulomas显示文摘AIM: To determine the most frequent etiologies of hepatic epithelioid granulomas, and whether there was an association with chronic hepatitis C virus (HCV). METHODS: Both a retrospective review of the pathol-ogy database of liver biopsies at our institution from 1996 through 2006 as well as data from a prospective study of hepatic fibrosis markers and liver biopsies from 2003 to 2006 were reviewed to identify cases of hepatic epithelioid granulomas. Appropriate charts, liver biopsy slides, and laboratory data were reviewed to determine all possible associations. The diagnosis of HCV was based on a positive HCV RNA. RESULTS: There were 4578 liver biopsies and 36 (0.79%) had at least one epithelioid granuloma. HCV was the most common association. Fourteen patients had HCV, and in nine, there were no concurrent conditions known to be associated with hepatic granulomas. Prior interferon therapy and crystalloid substances from illicit intravenous injections did not account for the fi nding. There were hepatic epithelioid granulomas in 3 of 241 patients (1.24%) with known chronic HCV enrolled in the prospective study of hepatic fibrosis markers. CONCLUSION: Although uncommon, hepatic granulomas may be part of the histological spectrum of chronic HCV. When epithelioid granulomas are found on the liver biopsy of someone with HCV, other clinically appropriate studies should be done, but if nothing else is found, the clinician can be comfortable with an HCV association. | Ned Snyder Juan G Martinez Shu-Yuan Xiao | 2008 | World Journal of Gastroenterology2008，14，41： | 2 |
| 3 | Facilitated sprouting in a peripheral nerve injury显示文摘 | Xu Q G Midha R Martinez J A | 2008 | Neuroscience2008，152，： | 1 |
| 4 | Analytic relation between bulk moduli and lattice constants显示文摘 | Cohen M L Martinez G | 1987 | Phys Rev B1987，35，17： | 1 |
| 5 | The impact of lung recruitment on hemodynamics during one-lung ventilation 显示文摘 | Garutti I Martinez G Cruz P | 2009 | Cardiothorac Vasc Anesth2009，23，4： | 1 |
| 6 | Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia 显示文摘 | PF REZ G R M VARGAS S R MARTINEZ M F J | 2004 | Phytother Res2004，18，5： | 1 |
| 7 | A spectral conjugate gradient method for unconstrained optimization 显示文摘 | BRINGIN E G MARTINEZ J M | 2001 | Applied Mathematics and Optimization2001，，43： | 1 |
| 8 | Theory of Acoustic Band Structure of Periodic Elastic Composites显示文摘 | Kushwaha M S Halevi P Martinez G | 1994 | Physical Review B1994，49，4： | 1 |
| 9 | Cytokines and autoimmune disease显示文摘 | Koremer G Martinez AC | 1991 | Clin Immunol Immunopathol1991，61，3： | 1 |
| 10 | Diagnostics for the developing world:microfluidic paper-based analytical devices显示文摘 | Martinez A W Phillips S T Whitesides G M | 2010 | Anal Chem2010，82，1： | 1 |
| 11 | General-purpose systems for effective construction simulation 显示文摘 | Martinez J C loannou P G | 1999 | Journal of Construction Engineering and Management (S0733-9634)1999，125，4： | 1 |
| 12 | Nanostructured Oxides in Chemistry显示文摘 | Fernandez G M Martinez A A Hanson J C | 2004 | Chem Rev2004，104，： | 1 |
| 13 | Landau level spectroscopy of ultrathin graphite layers显示文摘 | Sadowski M L Martinez G Potemski M | | 0，，26： | 1 |
| 14 | Molecular antagonism and plasticity of regulatory and inflammatory T cell programs显示文摘 | Yang XO Nurieva R Martinez G J | 2008 | Immunity2008，29，1： | 1 |
| 15 | Poly-lactic acid synthesis for application in biomedical devices-A review显示文摘 | Lasprilla A J R Martinez G A R Lunelli B H | 2012 | Biotechnology Advances2012，30，1： | 1 |
| 16 | Effect of superatmospheric and low oxygen modified atmo- spheres on shelf-life extension of fresh-cut melon显示文摘 | Oms-Oliu G Raybaudi-Massilia Martinez R M | 2008 | Food Control2008，19，： | 1 |
| 17 | Evidence for Cu Ion Formation by Dissolution and Dealloying the Al2CuMg Intermetallic Compound in Rotating Ring--dish Collection Experiments 显示文摘 | BUCHHEIT R G MARTINEZ M A MONTES L P | 2000 | J of the Electrochemical Society2000，147，： | 1 |
| 18 | Application of MRI to monitor the process of ripening and decay in citrus treated with chitosan solutions显示文摘 | Galed G Fernández-Valle M E Martinez A | 2004 | Magnetic Resonance Imaging2004，22，1： | 1 |
| 19 | Random ized clinical trial of fixation vs nonfixation of mesh in total extrapertioneal inguinal hemiop lasty显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 20 | Solid - phase Molecularly Imprinted on - line Preconcentration and Voltammetric Determination of Sulfamethazine in Milk 显示文摘 | De Prada A G V Martinez - Ruiz P Reviejo A J | 2005 | Anal Chim Acta2005，539，： | 1 |
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