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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics显示文摘AIM: To examine the effect of hepatitis C virus (HCV) structural mimics of regulatory regions of the genome on HCV replication.METHODS: HCV RNA structural mimics were constructed and tested in a HCV genotype 1b aBB7 replicon,and a Japanese fulminant hepatitis-1 (JFH-1) HCV genotype 2a infection model.All sequences were computer-predicted to adopt stem-loop structures identical to the corresponding elements in full-length viral RNA.Huh7.5 cells bearing the BB7 replicon or infected with JFH-1 virus were transfected with expression vectors generating HCV mimics and controls.Cellular HCV RNA and protein levels were quantified by real-time polymerase chain reaction and Western blotting,respectively.To evaluate possible antisense effects,complementary RNAs spanning a mimic were prepared.RESULTS: In the BB7 genotype 1b replicon system,mimics of the polymerase (NS-5B),X and BA regions inhibited replication by more than 90%,50%,and 60%,respectively.In the JFH-1 genotype 2 infection system,mimics that were only 74% and 46% identical in sequence relative to the corresponding region in JFH-1 inhibited HCV replication by 91.5% and 91.2%,respectively,as effectively as a mimic with complete identity to HCV genotype 2a.The inhibitory effects were confirmed by NS3 protein levels.Antisense RNA molecules spanning the 74% identical mimic had no significant effects.CONCLUSION: HCV RNA structural mimics can inhibit HCV RNA replication in replicon and infectious HCV systems and do so independent of close sequence identity with the target. | Robert Smolic Martina Smolic John H Andorfer Catherine H Wu Robert M Smith George Y Wu | 2010 | World Journal of Gastroenterology2010，16，17： | 2 |
| 3 | Prognostic Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide in Patients With Severe Sepsis 显示文摘 | Martina B Guenter H Siegfried L | 2005 | Circ2005，112，4： | 1 |
| 4 | Synthesis,crystal structure and magnetic properties of a ferromagnetically coupled difluoro-bridged dinuclear chromium(Ⅲ) complex with a substituted tetrahydros-alen derivative as ligand显示文摘 | Ralf S Arnd B Horst E Martina H Wolfgang H | 1996 | Inorg Chem1996，35，26： | 1 |
| 5 | Complex macromolecular architectures by reversible addition fragmentation chain transfer chemistry: Theory and practice 显示文摘 | Leonie Barner Thomas P Davis Martina H Stenzel | 2007 | Macromol Rapid Commun2007，28，5： | 1 |
| 6 | Factors influencing Comliance in Schizophrenia Patients显示文摘 | Wwolfgang F Martina H | 2003 | J Clin Psychiatry2003，64，： | 1 |
| 7 | Journal of polyer science part A 显示文摘 | Martina H S Thomas P D | 2002 | Polymer Chemisty2002，24，： | 1 |
| 8 | Symple- kin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevis oocytes 显示文摘 | ILSE H MARTINA S ISABELLE K | 2000 | Mol Biol Cell2000，13，： | 1 |
| 9 | Electric Field-Induced Aligned Multi-Wall Carbon Nanotube Networks in Epoxy Composites显示文摘 | Martina C A Sandlera J K W Windlea A H | 2005 | Polymer2005，46，： | 1 |
| 10 | Thin Solid Films显示文摘 | Bendavid A Martina P J Takikawa H | 2000 | 360:241-2492000，360，： | 1 |
| 11 | IKKαcontrols canonical TGFβ–SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cel s显示文摘 | Martina B Barbara S Ferdinand H | | 0，，24： | 1 |
| 12 | Inverse Jet Electrochemical Machining for Functional Edge Shaping of Micro Bores 显示文摘 | OSCHTZCHENA M H MARTINA A MEICHSNER G | 2013 | Procedia CIRP2013，，6： | 1 |
| 13 | Reducing the rate of preterm birth through a simple antenatal screen-and-treat programme :a retrospective cohort study显示文摘 | Kiss H Petricevic L Martina S | 2010 | Eur J Obstet Gyneco! Reprod Biol2010，153，1： | 1 |
| 14 | Development of pulmonary fibrosis through a pathway involving the tran- scription factor Fra-2/AP-I 显示文摘 | ROBERT E PETER H MARTINA R | 2008 | Proceedings of the Nation- al Academy of Sciences2008，105，10： | 1 |
| 15 | The mycosubtilin synthetase of Bacillus subtilis ATCC6633:A multifunctional hybrid between a peptide synthetase,an amino transferase,and a fatty acid synthase显示文摘 | ERWIN H D LEENDERT W H MARTINA R | 1999 | Proc Natl Acad Sci USA1999，96，13： | 1 |
| 16 | New hepatitis virus discovered显示文摘 | Martina H | 1999 | Molecular Medicine Today1999，5，11： | 1 |
| 17 | Permissive hypercapnia; role in protective lung ventilatory strategies显示文摘 | Martina N Brendan H John G | 2005 | Curt Opin Crit Care2005，11，1： | 1 |
| 18 | Extraction of copper, zinc, nickel and cobalt in acid oxidative leaching of chalcopyrite at the presence of deep-sea manganese nodules as oxidant 显示文摘 | Tomas H Martina L Andrea M | 2005 | Hydrometallurgy2005，77，： | 1 |
| 19 | Intestinal, adipose, and liver inflammation in diet-induced obese mice显示文摘 | Hong Li Christopher Lelliott Pernilla H?kansson Karolina Ploj Anna Tuneld Martina Verolin-Johansson Lambertus Benthem Bj?rn Carlsson Leonard Storlien Erik Micha?lsson | 2008 | Metabolism2008，，12： | 1 |
| 20 | Activated mammalian target of rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma显示文摘 | Beata H Harald P Martina L | 2007 | Clin Cancer Bes2007，13，16： | 1 |
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