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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Role of bronchoscopy in critically ill patients managed in intermediate care units - indications and complications: A narrative review显示文摘Flexible bronchoscopy(FB)has become a standard of care for the triad of inspection,sampling,and treatment in critical care patients.It is an invaluable tool for diagnostic and therapeutic purposes in critically ill patients in intensive care unit(ICU).Less is known about its role outside the ICU,particularly in the intermediate care unit(IMCU),a specialized environment,where an intermediate grade of intensive care and monitoring between standard care unit and ICU is provided.In the IMCU,the leading indications for a diagnostic work-up are:To visualize airway system/obstructions,perform investigations to detect respiratory infections,and identify potential sources of hemoptysis.The main procedures for therapeutic purposes are secretion aspiration,mucus plug removal to solve atelectasis(total or lobar),and blood aspiration during hemoptysis.The decision to perform FB might depend on the balance between potential benefits and risks due to frailty of critically ill patients.Serious adverse events related to FB are relatively uncommon,but they may be due to lack of expertise or appropriate precautions.Finally,nowadays,during dramatic recent coronavirus disease 2019(COVID-19)pandemic,the exact role of FB in COVID-19 patients admitted to IMCU has yet to be clearly defined.Hence,we provide a concise review on the role of FB in an IMCU setting,focusing on its indications,technical aspects and complications. | Vincenzo G Menditto Federico Mei Benedetta Fabrizzi Martina Bonifazi | 2021 | World Journal of Critical Care Medicine2021，10，6： | 3 |
| 3 | Optimization and implementation of the integer wavelet transform for image coding显示文摘 | GRANGETTO M MAGLI E MARTINA M OLMO G | 2002 | IEEE Trans2002，11，6： | 2 |
| 4 | Fea- sibility of CHP-plants with thermal stores in the German spot market 显示文摘 | STRECKIENE G MARTINAITIS V ANDERSEN A N | 2009 | Applied Energy2009，86，11： | 1 |
| 5 | Multiplierless,Folded 9/7-5/3 Wavelet VLSI Architecture显示文摘 | Martina M Masera G | | 0，，09： | 1 |
| 6 | Synesthesia: Strong and Weak显示文摘 | MARTINA G MARKS L E | 2001 | Current Directions in Psychological Science2001，10，2： | 1 |
| 7 | Wavelength demultiplexer using the spatial dispersion of multilayer thin-film structures显示文摘 | MARTINA G DAVIDA | 2003 | Photonics Technology Letters IEEE2003，15，8： | 1 |
| 8 | A VLP- based vaccine targeting domain Ⅲ of the West Nile virus E protein protects from lethal infection in mice 显示文摘 | Spohn G Jennings G T Martina B E | 2010 | Virol J2010，7，： | 1 |
| 9 | State Metric Compression Techniques for Turbo Decoder Architectures 显示文摘 | Martina M Masera G | 2011 | IEEE Circuits and Systems I: Regular Papers2011，58，5： | 1 |
| 10 | Influence of Neoadjuvant Therapy with Epirubicin and Docetaxel on the Expression of HER2/neu in Patients with Breast Cancer显示文摘 | Susanne Taucher Margaretha Rudas Robert M. Mader Michael Gnant Emanuel Sporn Peter Dubsky Sebastian Roka Thomas Bachleitner Florian Fitzal Daniela Kandioler Catharina Wenzel Günther G. Steger Martina Mittlb?ck Raimund Jakesz | 2003 | Breast Cancer Research and Treatment2003，，3： | 1 |
| 11 | Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of cbikungunya virus protects AG129 mice against lethal challenge 显示文摘 | van den Doel P Volz A Roose JM Sewbalaksing VD Pijlman GP van Middelkoop 1 Duiverman V van de Wetering E Sutter G Osterhaus AD Martina BE | 2014 | PLoS Negl Trop Dis2014，8，9： | 1 |
| 12 | Soil type is the primary determinant of the composition of the total and active bacterial communities in soils 显示文摘 | Martina S G juliet B Jules N P | 2003 | Appl Environ Microbiol2003，69，3： | 1 |
| 13 | l The relationship between alexithymia,depression,and sleep complaints显示文摘 | Gennaro L Martina M Curcio G eta | 2004 | Psychiatry Re-search2004，128，3： | 1 |
| 14 | Glass damage during dishwashing 显示文摘 | FRANCO G B MARTINA P MARCO V | 2002 | Rivista della Stazione Sperimentale del Vetro2002，32，： | 1 |
| 15 | A single institute, s experiencein retroperitoneal laparoscopic dismembered pyeloplasty :results with86 consecutive patients显示文摘 | Martina G R Verze P Giummelli P | 2011 | J Endourol2011，25，6： | 1 |
| 16 | SJWD15011600009512显示文摘 | Martina Vockerodt Lee‐Fah Yap Claire Shannon‐Lowe Helen Curley Wenbin Wei Katerina Vrzalikova Paul G Murray | 2015 | Pathol2015，，2： | 1 |
| 17 | Inverse Jet Electrochemical Machining for Functional Edge Shaping of Micro Bores 显示文摘 | OSCHTZCHENA M H MARTINA A MEICHSNER G | 2013 | Procedia CIRP2013，，6： | 1 |
| 18 | Optimization and implementation of the integer wavelet transform for image coding显示文摘 | Grangetto M Magli E Martina M Olmo G | | 0，，： | 1 |
| 19 | Destination image towards a conceptual Framework显示文摘 | Martina G Gallarza Irene Gil Saura Haydé e Caldró n Garcí a | 2001 | Annals of Tourism Research2001，29，1： | 1 |
| 20 | Value dimensions, perceived value, satisfaction and loyalty : an investigation of university students' travel behaviour显示文摘 | Martina G Gallarza Irene Gil Saura | 2006 | Tourism Management2006，27，3： | 1 |
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