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| 1 | Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber显示文摘Achieving intravital optical imaging with diffraction-limited spatial resolution of deep-brain structures represents an important step toward the goal of understanding the mammalian central nervous system1–4.Advances in wavefrontshaping methods and computational power have recently allowed for a novel approach to high-resolution imaging,utilizing deterministic light propagation through optically complex media and,of particular importance for this work,multimode optical fibers(MMFs)5–7.We report a compact and highly optimized approach for minimally invasive in vivo brain imaging applications.The volume of tissue lesion was reduced by more than 100-fold,while preserving diffraction-limited imaging performance utilizing wavefront control of light propagation through a single 50-μm-core MMF.Here,we demonstrated high-resolution fluorescence imaging of subcellular neuronal structures,dendrites and synaptic specializations,in deep-brain regions of living mice,as well as monitored stimulus-driven functional Ca2+responses.These results represent a major breakthrough in the compromise between high-resolution imaging and tissue damage,heralding new possibilities for deep-brain imaging in vivo. | Sebastian A.Vasquez-Lopez Raphaël Turcotte Vadim Koren Martin Plöschner Zahid Padamsey Martin J.Booth TomášČižmár Nigel J.Emptage | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation显示文摘Short bowel syndrome (SBS) refers to the malabsorption of nutrients, water, and essential vitamins as a result of disease or surgical removal of parts of the small intestine. The most common reasons for removing part of the small intestine are due to surgical intervention for the treatment of either Crohn's disease or necrotizing enterocolitis. Intestinal adaptation following resection may take weeks to months to be achieved, thus nutritional support requires a variety of therapeutic measures, which include parenterai nutrition. Improper nutrition management can leave the SBS patient malnourished and/or dehydrated, which can be life threatening. The development of therapeutic strategies that reduce both the complications and medical costs associated with SBS/long-term parenterai nutrition while enhancing the intestinal adaptive response would be valuable. Currently, therapeutic options available for the treatment of SBS are limited. There are many potential stimulators of intestinal adaptation including peptide hormones, growth factors, and neuronally-derived components. Glucagon-like peptide-2 (GLP-2) is one potential treatment for gastrointestinal disorders associated with insufficient mucosal function. A significant body of evidence demonstrates that GLP-2 is a trophic hormone that plays an important role in controlling intestinal adaptation. Recent data from clinical trials demonstrate that GLP-2 is safe, well-tolerated, and promotes intestinal growth in SBS patients. However, the mechanism of action and the localization of the glucagon-like peptide-2 receptor (GLP-2R) remains an enigma. This review summarizes the role of a number of mucosal-derived factors that might be involved with intestinal adaptation processes; however, this discussion primarily examines the physiology, mechanism of action, and utility of GLP-2 in the regulation of intestinal mucosal growth. | GR Martin PL Beck DL Sigalet | 2006 | World Journal of Gastroenterology2006，12，26： | 3 |
| 3 | Diabetes insipidus and adipsic hypermatremia in a patient with a craniopharyngioma显示文摘 | Macias Batista A Martinez Martin F J de Pablos Velasco PL | 1999 | An Med Interna1999，16，2： | 1 |
| 4 | Multielement analysis of tea beverages by inductively coupled plasma atomic emission spectrometry显示文摘 | Fernandez PL Pablos F Martin MJ | 2002 | Food Chem2002，76，： | 1 |
| 5 | Photodynamic treatment for lower genital tract intraepithelial neoplasia显示文摘 | Martin Hirsch PL Whitehurst C Bucklev CH | | 0，，： | 1 |
| 6 | CYP1B1 and hormone-in- duced cmcer显示文摘 | Gajjar K Martin-Hirsch PL Martin FL | 2012 | Cancer Letters2012，324，1： | 1 |
| 7 | Management of des- moid-type fibromatosis involving peripheral nerves 显示文摘 | Siqueira MG Tavares PL Martins RS | 2012 | Arq Neurop- siquiatr2012，70，7： | 1 |
| 8 | Improvement in survival after Paraquat ingestion following introduetion of a new formulation in Sri Lanka显示文摘 | Martin FW Ravindra F Ariyananda PL | 2008 | PLoS Medicine2008，5，： | 1 |
| 9 | Personality correlates of depression and health symptoms : a test of a self - regulation mod- el显示文摘 | Martin TR Flett GL Hewitt PL | 1996 | Journal of Research in Personality1996，3，： | 1 |
| 10 | Progestagens for endometrial cancer 显示文摘 | Martin -Hirsch PL Jarvis G KitchenerH | 2000 | Cochrane Database Syst Rev2000，2，： | 1 |
| 11 | CYP1 B1 and hormone-induced cancer 显示文摘 | Gajjar K Martin-Hirsch PL Martin FL | 2012 | Cancer Lett2012，324，： | 1 |
| 12 | Characterizing the contribution of stem/progenitor cells to tumorigenesis in the Pten-/-TP53-/-prostate cancer model显示文摘 | Abou WG Hynes PG Martin PL | | 0，，12： | 1 |
| 13 | Supraglottic and pharyngeal sensory abnormalities in stroke patients with dysphagia显示文摘 | Aviv JE Sacco PL | 1996 | Ann Otol Rhinol Laryngol1996，105，： | 1 |
| 14 | Results of, the cord blood transplantation study(COBLT):outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with lysosomal and peroxisomal storage diseases显示文摘 | Martin PL Carter SL Kernan NA | 2006 | Biol Blood Marrow Transplant2006，12，2： | 1 |
| 15 | CYP 1B 1 and hormone-induced cancer显示文摘 | Gajjar K Martin-Hirsch PL Martin FL | 2012 | Cancer Lett2012，324，1： | 1 |
| 16 | Evaluation of linezolid, vancomycin, gentamicin and ciprofloxacin in a rabbit model of antibiotic-lock technique for Staphylococcus aureus catheter-related infection 显示文摘 | Ferndndez-Hidalgo N Gavald J Almirante B Martin MT Onrubia PL Gomis X Pahissa A | 2010 | J Antimicrob Chemother2010，65，3： | 1 |
| 17 | Stimulator with arbitrary waveform for attctitory, ew, ked potentials显示文摘 | Martins ilR Romao M Pl hcido D | 2007 | Journal of Physics C mference Series2007，90，01： | 1 |
| 18 | Estrogen therapy arrests bone loss on elderly women显示文摘 | Quigley MER Martin PL Burnier AM | 1987 | Am J Obstet G ynecol1987，156，： | 1 |
| 19 | Study of catechinand xanthine tea profiles as geographical tracers显示文摘 | Fernández PL Pablos F Martin MJ | 2002 | Journalof Agricultural and Food Chemistry2002，50，： | 1 |
| 20 | Effects of an anti-TNF- alpha monoclonal antibody, administered throughout pregnancy and lactation, on the development of the macaque immune system 显示文摘 | MARTIN PL ONEDA S TREACY G | 2007 | Am J Reprod Immunol2007，58，2： | 1 |
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