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| 1 | Molecular and Physiological Analysis of Growth-Limiting Drought Stress in Brachypodium distachyon Leaves显示文摘干旱容忍的草 Brachypodium distachyon 是为适度的草和谷物庄稼的新兴的模型种。为了为干旱探索这种的实用性,学习,一在 vivo 可再现干旱试金被开发。弄干的自发的土壤在叶尺寸导致了 45% 减小,并且这主要由于在细胞扩大的减少,而细胞分割由干旱仍然保持大部分未受影响。调查观察的叶生长减小的分子的基础,第三片 Brachypodium 叶在三个地区被把,也就是增长,扩大,和成熟地区,并且使分析遭到了到 transcriptome,基于一个整个染色体的并列数组。这条途径允许我们加亮不同的发展的叶地区的侧面不同地回答到干旱的那 transcriptome。涉及干旱忍耐的几基因和功能的过程被识别。transcriptome 数据在增长地区建议增加的精力可获得性,与甾醇合成的一条起来规定一起,那可以影响膜流动性。这个信息可以被用来改进适度的谷物的忍耐到干旱,它无疑是今天并且在不久的将来的农业面对的主要环境挑战之一。 | Wim Verelst Edoardo Bertolini Stefanie De Bodt Klaas Vandepoele Marlies Demeulenaere Mario Enrico pè Dirk Inzé | 2013 | Molecular Plant2013，6，2： | 6 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Molecular nature of virulence in Entamoeba histolytica显示文摘 | Alfonso Olivos-García Emma Saavedra Espiridión Ramos-Martínez Mario Nequiz Ruy Pérez-Tamayo | 2009 | Infection Genetics and Evolution2009，，6： | 2 |
| 4 | Use of intercostal nerves for different target neurotization in brachial plexus reconstruction显示文摘Intercostal nerve transfer is a valuable procedure in devastating plexopathies. Intercostal nerves are a very good choice for elbow flexion or extension and shoulder abduction when the intraplexus donor nerves are not available. The best results are obtained in obstetric brachial plexus palsy patients, when direct nerve transfer is performed within six months from the injury. Unlike the adult posttraumatic patients after median and ulnar nerve neurotization with intercostal nerves, almost all obstetric brachial plexus palsy patients achieve protective sensation in the hand and some of them achieve active wrist and finger flexion. Use in combination with proper muscles, intercostal nerve transfer can yield adequate power to the paretic upper limb. Reinnervation of native muscles(i.e., latissimus dorsi) should always be sought as they can successfully be transferred later on for further functional restoration. | Marios G Lykissas Ioannis P Kostas-Agnantis Ananstasios V Korompilias Marios D Vekris Alexandros E Beris | 2013 | World Journal of Orthopedics2013，4，3： | 2 |
| 5 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 6 | Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting显示文摘 | Piatti P Di Mario C Monti LD | 2003 | Circulation2003，108，17： | 1 |
| 7 | Semicon-ductor Nanocrystals as Fluorescent Biological Labels显示文摘 | Bruchez Marcel Jr Moronne Mario Gin P | 1998 | Science1998，281，： | 1 |
| 8 | Congruences on inverse semigroups 显示文摘 | MARIO P | 1978 | JouInal Algebra1978，55，4： | 1 |
| 9 | Elderly patients on dialysis: Epidemiology of an epidemic显示文摘 | GIUSEPPE P MARIO S BARBARA P G | 1996 | Nephrol Dail Transplant1996，11，9： | 1 |
| 10 | Upgrading HeavyOil Using Slurry Processes 显示文摘 | Aiberto D B Nicoietta P Mario M | 1995 | ChemTech1995，25，11： | 1 |
| 11 | Upgrading heavy oil using slurry processes显示文摘 | ALBERTO D B NICOLETTA P MARIO M | 1995 | Chemtech1995，25，11： | 1 |
| 12 | Token bucket characterization of long-range dependent traffic显示文摘 | GREGORIO P ANURAG G MARIO G | 2002 | Computer Communication2002，25，11： | 1 |
| 13 | Treatment of aqueous effluent for fluoride removal显示文摘 | John P B Marios T | 1987 | J Water Pollut Control Fed1987，59，： | 1 |
| 14 | Removal of hazardous organic pollutants by biomass adsorption 显示文摘 | JOHN P B MARIOS T | 1987 | Journal Water Pollution Control Federation1987，59，4： | 1 |
| 15 | Methanolysis of soybean oil in the presence of tin ( IV ) complexes 显示文摘 | Davi A C Ferreira Mario R Meneghett Simoni M P Me- neghetti | 2007 | Applied Catalysis A : General2007，317，1： | 1 |
| 16 | Measuring triggering interaction complexity on active database显示文摘 | Oscar D Mario P Coral C | 2001 | Information Systems2001，26，1： | 1 |
| 17 | Cognitive function and behavior of children with adenotonsillar hypertrophy suspected of having obstructive sleep-disordered breathing 显示文摘 | PAUL M SURATT M D MARIO P | 2006 | Pediatrics2006，118，3： | 1 |
| 18 | Aerothermodynamic study of UHTC-based thermal protection systems显示文摘 | RAFFAELE S MARIO S F DIEGO P | 2005 | Aerosp Sci Technol2005，9，： | 1 |
| 19 | Intrarenal hemo- dynamic and oxidative stress in patients with obstructive sleep apnea syndrome显示文摘 | SARDO L PALANGE P DI MARIO F | 2015 | Sleep Breath2015，19，4： | 1 |
| 20 | High-resolution CT in silicosis correlation with radiographic findings and functional impairment显示文摘 | VINICIUS C S A GERMANIA A P MARIO T F | 2005 | J Comput Assist Tomogr2005，29，： | 1 |
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