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| 1 | Autoimmune liver serology:Current diagnostic and clinical challenges显示文摘Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseas-es(AiLD),namely autoimmune hepatitis types 1 and 2(AIH-1 and 2),primary biliary cirrhosis(PBC),and the sclerosing cholangitis variants in adults and children.AIH-1 is specified by anti-nuclear antibody(ANA) and smooth muscle antibody(SMA).AIH-2 is specified by antibody to liver kidney microsomal antigen type-1(anti-LKM1) and anti-liver cytosol type 1(anti-LC1).SMA,ANA and anti-LKM antibodies can be present in de-novo AIH following liver transplantation.PBC is specified by antimitochondrial antibodies(AMA) react-ing with enzymes of the 2-oxo-acid dehydrogenase complexes(chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly react-ing with nuclear pore gp210 and nuclear body sp100.Sclerosing cholangitis presents as at least two variants,first the classical primary sclerosing cholangitis(PSC) mostly affecting adult men wherein the only(and non-specific) reactivity is an atypical perinuclear antineutro-phil cytoplasmic antibody(p-ANCA),also termed peri-nuclear anti-neutrophil nuclear antibodies(p-ANNA) and second the childhood disease called autoimmune sclerosing cholangitis(ASC) with serological features resembling those of type 1 AIH.Liver diagnostic serol-ogy is a fast-expanding area of investigation as new purified and recombinant autoantigens,and automatedtechnologies such as ELISAs and bead assays,become available to complement(or even compete with) tradi-tional immunofluorescence procedures.We survey for the first time global trends in quality assurance impact-ing as it does on(1) manufacturers/purveyors of kits and reagents,(2) diagnostic service laboratories that fulfill clinicians' requirements,and(3) the end-user,the physician providing patient care,who must properly interpret test results in the overall clinical context. | Dimitrios P Bogdanos Diego Vergani Pietro Invernizzi Ian R Mackay | 2008 | World Journal of Gastroenterology2008，14，21： | 40 |
| 2 | Endoscopic ultrasonography-guided celiac plexus neurolysis in patients with unresectable pancreatic cancer: An update显示文摘Pancreatic cancer produces disabling abdominal pain,and the pain medical management for pancreatic cancer is often challenging because it mainly relies on the use of narcotics(major opioids).However,opioids often provide suboptimal pain relief,and the use of opioids can lead to patient tolerance and several side effects that considerably reduce the quality of life of pancreatic cancer patients.Endosonography-guided celiac plexus neurolysis(EUS-CPN)is an alternative for pain control in patients with nonsurgical pancreatic cancer;EUS-CPN consists of the injection of alcohol and a local anesthetic into the area of the celiac plexus to achieve chemical ablation of the nerve tissue.EUS-CPN via the transgastric approach is a safer and more accessible technique than the percutaneous approach.We have reviewed most of the studies that evaluate the efficacy of EUSCPN and that have compared the different approaches that have been performed by endosonographers.The efficacy of EUS-CPN varies from 50%to 94%in the different studies,and EUS-CPN has a pain relief duration of 4–8 wk.Several factors are involved in its efficacy,such as the onset of pain,previous use of chemotherapy,presence of metastatic disease,EUS-CPN technique,type of needle or neurolytic agent used,etc.According to this review,injection into the ganglia may be the best technique,and a good visualization of the ganglia is the best predictor for a good EUS-CPN response,although more studies are needed.However,any of the 4 different techniques could be used to perform EUS-CPN effectively with no differences in terms of complications between the techniques,but more studies are needed.The effect of EUS-CPN on pain improvement,patient survival and patient quality of life should be evaluated in well-designed randomized clinical trials.Further research also needs to be performed to clarify the best time frame in performing a EUS-CPN. | Guillermo Pérez-Aguado Diego Martinez-Acitores de la Mata Carlos Marra-López Valenciano Ignacio Fernandez-Urien Sainz | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，10： | 4 |
| 3 | Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López | 2023 | Neural Regeneration Research2023，18，9： | 3 |
| 4 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 5 | Plant protection and growth stimulation by microorganisms: biotechnological applications of Bacilli in agriculture显示文摘 | Alejandro Pérez-García Diego Romero Antonio de Vicente | 2010 | Current Opinion in Biotechnology2010，，2： | 2 |
| 6 | Immunol- ogical Response to Mycoplasma pneu- moniae(Mp)and CARDS Toxin Is Related to Severe Histological Inflammation and a TH2 Response in a Primate Model显示文摘 | Diego M Jay P Jorge M | 2012 | Chest2012，142，4： | 1 |
| 7 | Solid waste management of a chemical-looping combustion plant using Cu-based oxygen carriers显示文摘 | Labiano F G Gayan P Adanez de Diego L Forero C R | 2007 | Environment Science Technology2007，41，6： | 1 |
| 8 | Effect of support on reactivity and selectivity of Ni-based oxygen carriers for chemieal- looping combustion 显示文摘 | GayOn P Diego de L F Garcia-Labiano F | 2008 | Fuel2008，87，12： | 1 |
| 9 | A meta- analysis of bees' responses to anthropogenic disturbance显示文摘 | Winfree R Aguilar R Diego P V | 2009 | Ecology2009，90，8： | 1 |
| 10 | Radial gas mixing in a circulating fluidized bed 显示文摘 | GAYAN P DIEGO L F ADANEZ J | 1997 | Powder Technology1997，94，2： | 1 |
| 11 | Fluorescence and CD spectroscopic analysis of the α-chymotrypsin stabilization by the ionic liquid, 1-ethyl-3-methylimidazolium bis amide显示文摘 | Diego T D Lozano P Gmouh S Vaultier M Iborra J L | 2004 | Biotechnol Bioeng2004，88，： | 1 |
| 12 | Synthesis of glyeidyl esters catalyzed by lipases in ionic liquids and supercritical carbon dioxide 显示文摘 | LOZANO P DIEGO T D CARRI D | 2004 | Journal of Molecular Catalysis A : Chemical2004，214，： | 1 |
| 13 | Effect of support on reacativity and selectivity of Ni-based oxygen carriers for chemical-looping combustion显示文摘 | Gay An P Diego L F García-Labiano F | 2008 | Fuel2008，87，： | 1 |
| 14 | Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency显示文摘 | Sancho-Shimizu Vanessa de Diego Rebeca Pérez Lorenzo Lazaro Halwani Rabih Alangari Abdullah Israelsson Elisabeth Fabrega Sylvie Cardon Annabelle Maluenda Jerome Tatematsu Megumi Mahvelati Farhad Herman Melina Ciancanelli Michael Guo Yiqi AlS | 2011 | Journal of Clinical Investigation2011，，12： | 1 |
| 15 | Aerothermodynamic study of UHTC-based thermal protection systems显示文摘 | RAFFAELE S MARIO S F DIEGO P | 2005 | Aerosp Sci Technol2005，9，： | 1 |
| 16 | Chemical characterization and ecotoxicity of three soil foaming agents used in mechanized tunneling显示文摘 | Diego B Eleonora L Alice P | 2015 | Journal of Hazardous Materials2015，296，： | 1 |
| 17 | An effi- cient activity ionic liquid - enzyme system for biodiesel production 显示文摘 | DE DIEGO T MANJ N A LOZANO P | 2011 | Green Chem2011，13，2： | 1 |
| 18 | Understanding structure-stability relationships of Candida antartica Lipase B in ionic liquids 显示文摘 | DIEGO T D LOZANO P GMOUH S | 2005 | Biomacromolecules2005，6，3： | 1 |
| 19 | Stabilization of a- chymotrypsin by ionic liquids in transesterification reactions 显示文摘 | Lozano P Diego T Guegan J P | 2001 | Biotechnology and Bioengineering2001，75，5： | 1 |
| 20 | Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in In Vitro fertilization-embryo transfer patients显示文摘 | Monika W Diego G Elisabeth P | 2009 | J Assist Reprod Genet2009，26，6： | 1 |
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