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| 1 | 小型激光天文动力学空间计划概念显示文摘小型激光天文动力学空间计划是 :使用在太阳轨道上无拖曳航天器和地面站以激光干涉和脉冲测距的方法 ,精确地探讨天文动力学 ,检测相对论与时空基本定律 ,改进探测引力波的灵敏度以及更准确地测定太阳、行星和小行星的参数。 1 969年开始的月球激光 (反射 )测距 ,对地球物理、参考坐标的选定、相对论的检验均有重要的贡献。 3 0年来 ,激光技术的长足进步 ,使现在正是适合于开始进行研究空间有源 (主动 )测距和光波空间通讯的时候。激光天文动力学的兴起是必然的趋势 ,其精确度将比现在提高 3到 6个数量级 ,将是天文动力学革命性的发展。小型激光天文动力学空间计划可以起到带头作用。它的关键技术有三 ,即 :弱光锁相、极精确无拖曳航天和高衰减日冕仪。弱光锁相已有长足的进步。对高衰减日冕仪的研究 ,也有了初步的方案。LISA空间计划将于 2 0 0 6年 8月发射SMART -2 ,研究测试极精确无拖曳航天。小型激光天文动力学空间计划的关键技术已日趋成熟。在第一届国际激光天文动力学研讨会 ( 2 0 0 1 ,9.1 3 -2 3 )中介绍了各相关学科背景及前沿研究 ,讨论了激光天文动力学空间计划科学目标及相关技术 ,并召开了两次小型激光天文动力学空间计划预研究筹备会 ,建立了和欧洲的合作关系。会后着手进行此项对基础? | 倪维斗 朱进 武向平 褚桂柏 杨彬 高健 关敏 汤健仁 周翊 张中豪 黄天衣 曲钦岳 易照华 李广宇 陶金河 吴岸明 罗俊 叶贤基 周泽兵 熊耀恒 毕少兰 须重明 吴雪君 唐孟希 包芸 李芳昱 黄珹 杨福民 叶叔华 张书练 张元仲 聂玉昕 陈光 Joergen Christensen-Dalsgaard Hansjoerg Dittus Yasunori Fujii Claus Laemmerzahl Jean Francois Mangin Achim Peters Albrecht Ruediger Etienne Samain Stephan Schiller | 2002 | 云南天文台台刊2002，，3： | 3 |
| 2 | Juvenile ferric iron prevents microbiota dysbiosis and colitis in adult rodents显示文摘AIM: To assess whether juvenile chronic ferric iron ingestion limit colitis and dysbiosis at adulthood in rats and mice. METHODS: Two sets of experiments were designed. In the first set, recently weaned mice were either orally administered ferrous (Fe2+) iron salt or ferric (Fe3+) microencapsulated iron for 6 wk. The last week of experiments trinitrobenzene sulfonic acid (TNBS) colitis was induced. In the second set, juvenile rats received the microencapsulated ferric iron for 6 wk and were also submitted to TNBS colitis during the last week of experiments. In both sets of experiments, animals were sacrificed 7 d after TNBS instillation. Severity of the inflammation was assessed by scoring macroscopic lesions and quantifying colonic myeloperoxidase (MPO) activity. Alteration of the microflora profile was estimated usingquantitative polymerase chain reaction (qPCR) by measuring the evolution of total caecal microflora, Bacteroidetes, Firmicutes and enterobacteria. RESULTS: Neither ferrous nor ferric iron daily exposures at the juvenile period result in any effect in control animals at adulthood although ferrous iron repeated administration in infancy limited weight gain. Ferrous iron was unable to limit the experimental colitis (1.71 ± 0.27 MPO U/mg proteinvs 2.47 ± 0.22 MPO U/mg protein in colitic mice). In contrast, ferric iron significantly prevented the increase of MPO activity (1.64 ± 0.14 MPO U/mg protein) in TNBS-induced colitis. Moreover, this positive effect was observed at both the doses of ferric iron used (75 and 150 mg/kg per day po - 6 wk). In the study we also compared, in both rats and mice, the consequences of chronic repeated low level exposure to ferric iron (75 mg/kg per day po - 6 wk) on TNBS-induced colitis and its related dysbiosis. We confirmed that ferric iron limited the TNBS-induced increase of MPO activity in both the rodent species. Furthermore, we assessed the ferric iron incidence on TNBS-induced intestinal microbiota dysbiosis. At first, we needed to optimize the isolation and quantify DNA copy numbers using standard curves to perform by qPCR this interspecies comparison. Using this approach, we determined that total microflora was similar in control rats and mice and was mainly composed of Firmicutes and Bacteroidetes at a ratio of 10/1. Ferric juvenile administration did not modify the microflora profile in control animals. Total microflora numbers remained unchanged whichever experimental conditions studied. Following TNBS-induced colitis, the Firmicutes/Bacteroidetes ratio was altered resulting in a decrease of the Firmicutes numbers and an increase of the Bacteroidetes numbers typical of a gut inflammatory reaction. In parallel, the subdominant population, the enterobacteria was also increased. However, ferric iron supplementation for the juvenile period prevented the increase of Bacteroidetes and of enterobacteria numbers consecutive to the colitis in both the studied species at adulthood.CONCLUSION: Rats and mice juvenile chronic ferric iron ingestion prevents colitis and dysbiosis at adulthood as assessed by the first interspecies comparison. | Chourouk Ettreiki Pascale Gadonna-Widehem Irène Mangin Mose Coёffier Carine Delayre-Orthez Pauline M Anton | 2012 | World Journal of Gastroenterology2012，18，21： | 3 |
| 3 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 4 | Instantaneous Parameter Estimation in cardiovascular time-frequency analysis 显示文摘 | Monti A Medigue C Mangin L | 2002 | IEEE Transactions on Biomedical Engineering2002，49，12： | 1 |
| 5 | A pilot-scale study of struvite precipitation in a stirred tank reactor:Conditions influencing the process显示文摘 | Pastor L Mangin D Barat R | 2008 | Bioresource Technology2008，99，14： | 1 |
| 6 | Diffusion tensor imaging: concepts and applicatior显示文摘 | Le Brhan D Mangin JF Poupon C | 2001 | Magn Reson Imaging2001，13，4： | 1 |
| 7 | Diffusion tensor imaging:concepts and applications 显示文摘 | Le Bihan D Mangin J F Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 8 | Diffusion tensor imaging: concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 9 | MMCs for automotive engine applications显示文摘 | Mangin C Isaaes J A Clark J P | 1996 | JOM1996，48，2： | 1 |
| 10 | Chronobiology of labour pain perception: an observational study 显示文摘 | Aya A G Vialles N Mangin R | 2004 | Br J Anaesth2004，93，3： | 1 |
| 11 | 16s rRNA and 16s to 23s internal transcribed spacer sequence analyses reveal inter- and intraspecific bifidobacterium phylogeny显示文摘 | Leblond-Bourget N Philippe H Mangin I | 1996 | Int J Syst Bacteriol1996，46，1： | 1 |
| 12 | Diffusion tensor imaging:concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | | 0，，： | 1 |
| 13 | 'Sulcal root' generic model:a hypothesis to overcome the variability of the human cortex folding patterns显示文摘 | Régis J Mangin JF Ochiai T | | 0，，： | 1 |
| 14 | The effect of parasites on host populationdensity and extinction: experimental epidemiology with Daphnia and six microparasites显示文摘 | Ebert D Lipstich M Mangin K L | 2000 | American Natrualist2000，156，： | 1 |
| 15 | Merged satellite ocean color data products using a bio -optical model: Char- acteristics, benefits and issues显示文摘 | Maritorena S dndon O H F Mangin A | 2010 | Remote Sensing of Environment2010，114，8： | 1 |
| 16 | Pourune meilleure connaissance des systmes hydrologique dpartir des analyses corrfilatoire et spectrale 显示文摘 | Mangin A | 1984 | Journal of Hydrology1984，67，1： | 1 |
| 17 | Diffusion tensor imaging:concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | | 0，，04： | 1 |
| 18 | Vancomycin pharmaeokinetic and pharmaeodynamic models for critically ill patients with post-sternotomy mediastinitis 显示文摘 | Mangin O Urien S Mainardi JL | 2014 | Clin Parmacokinet2014，53，9： | 1 |
| 19 | Diffusion tensor imaging: concepts and applications 显示文摘 | Le Bihan D Mangin JF Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 20 | Detection of linear features in SAR images: application to road network extraetion 显示文摘 | Tupin F Maitre H Mangin J F | 1998 | IEEE Transaetions on Geoscience and Remote Sensing1998，36，2： | 1 |
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