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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | 全球MRSA负荷增加和潜在的临床提示显示文摘上世纪60年代,MRSA第一次被作为医疗机构相关感染的病原体进行报道。在美国,国家院内感染监视系统报告在2003年MRSA的感染相比1998-2002年的记录增加了12%。目前从危重患者收集分离的金黄色葡萄球菌中超过63%为MRSA。MRSA在全美流行。同时,在欧洲和亚洲MRSA的感染也逐渐受到重视,MRSA目前已经成为全球性问题。 | D E Low 张静(译) | 2008 | 中华医学信息导报2008，23，13： | 2 |
| 3 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 4 | The reflection of guided waves from circumferential notches in pipes 显示文摘 | Alleyne D N Lowe M J S Cawley P | 1998 | Trans ASME J of Appl Mech1998，65，： | 2 |
| 5 | Nutrient removal from eutrophic lake water by wetland filtration显示文摘 | Stites D L Lowe E F | 2002 | Ecological Engineering2002，19，2： | 1 |
| 6 | Distinctive image features from scale-invariant keypoints显示文摘 | Lowe D | 2004 | International Journal of Computer Vision2004，60，2： | 1 |
| 7 | Distinctive image features from scale-invariant keypoints显示文摘 | Lowe D | 2004 | International Journal of Computer Vision2004，60，2： | 1 |
| 8 | Use of endoscopy for management of acute upper gastrointestinal bleeding in the UK:results of a nationwide audit显示文摘 | Hearnshaw SA Logan RF Lowe D | 2010 | Gut2010，59，8： | 1 |
| 9 | Distinctive image features from scaIe-invariant keypoints显示文摘 | Lowe D G | 2004 | Int J Comput Vision2004，，2： | 1 |
| 10 | Distinctive image features from scale-invariant keypoints显示文摘 | Lowe D G | 2004 | International Journal of Computer Vision2004，60，2： | 1 |
| 11 | Distinctive image features from scale-invariant key points显示文摘 | Lowe D G | 2004 | lntemational Journal of Computer Vision2004，60，2： | 1 |
| 12 | The influence of sediment recycling and basement composition on evolution of mudrock chemistry in the southwestern United States显示文摘 | COX R LOW D R | 1995 | Geochimica et Cosmochimica Acta1995，59，： | 1 |
| 13 | Identification of severe acute respiratory syndrome in Canada显示文摘 | Poutanen S M Low D E Henry B | 2003 | N Engl J Med2003，348，20： | 1 |
| 14 | The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine显示文摘 | Paraskevopoulou C Fairhurst S A Lowe D J | 2006 | Mol Microbiol2006，59，3： | 1 |
| 15 | Invasive infection due to Streptococcus iniae: a new or previously unrecognized disease显示文摘 | WEINSTEIN M R LOW D E McGeer A | 1996 | Ontario CCDR1996，22，： | 1 |
| 16 | Distinctive image features from scale-invariant keypoints显示文摘 | Lowe D G | 2004 | International Journal of Computer Vision2004，60，2： | 1 |
| 17 | Infiltration and physical character istics of functionally graded alumina/ calcium- hexaluminate composites 显示文摘 | Asmi D Low I M | 2001 | Journal of Materials Processing Technology2001，118，： | 1 |
| 18 | Distinctive Image Features from Scale-Invariant Key Points显示文摘 | Lowe D G | 2004 | International Journal of Computer Vision2004，60，2： | 1 |
| 19 | Facial morphology and obstructive sleep apnea显示文摘 | Lowe A A Santamaria J D Fleetham J A | | 0，，6： | 1 |
| 20 | Efficacy and safety of antioxidant treatment with alpha-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial 显示文摘 | Ziegler D Low PA Litchy WJ | 2011 | Diabe- tes Care2011，34，9： | 1 |
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