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| 1 | Global kinematics of tectonic plates and subduction zones since the late Paleozoic Era显示文摘Detailed global plate motion models that provide a continuous description of plate boundaries through time are an effective tool for exploring processes both at and below the Earth's surface. A new generation of numerical models of mantle dynamics pre-and post-Pangea timeframes requires global kinematic descriptions with full plate reconstructions extending into the Paleozoic(410 Ma). Current plate models that cover Paleozoic times are characterised by large plate speeds and trench migration rates because they assume that lowermost mantle structures are rigid and fixed through time. When used as a surface boundary constraint in geodynamic models, these plate reconstructions do not accurately reproduce the present-day structure of the lowermost mantle. Building upon previous work, we present a global plate motion model with continuously closing plate boundaries ranging from the early Devonian at 410 Ma to present day.We analyse the model in terms of surface kinematics and predicted lower mantle structure. The magnitude of global plate speeds has been greatly reduced in our reconstruction by modifying the evolution of the synthetic Panthalassa oceanic plates, implementing a Paleozoic reference frame independent of any geodynamic assumptions, and implementing revised models for the Paleozoic evolution of North and South China and the closure of the Rheic Ocean. Paleozoic(410-250 Ma) RMS plate speeds are on average ~8 cm/yr, which is comparable to Mesozoic-Cenozoic rates of ~6 cm/yr on average.Paleozoic global median values of trench migration trend from higher speeds(~2.5 cm/yr) in the late Devonian to rates closer to 0 cm/yr at the end of the Permian(~250 Ma), and during the Mesozoic-Cenozoic(250-0 Ma) generally cluster tightly around ~1.1 cm/yr. Plate motions are best constrained over the past 130 Myr and calculations of global trench convergence rates over this period indicate median rates range between 3.2 cm/yr and 12.4 cm/yr with a present day median rate estimated at~5 cm/yr. For Paleozoic times(410-251 Ma) our model results in median convergence rates largely~5 cm/yr. Globally,~90% of subduction zones modelled in our reconstruction are determined to be in a convergent regime for the period of 120-0 Ma. Over the full span of the model, from 410 Ma to 0 Ma,~93% of subduction zones are calculated to be convergent, and at least 85% of subduction zones are converging for 97% of modelled times. Our changes improve global plate and trench kinematics since the late Paleozoic and our reconstructions of the lowermost mantle structure challenge the proposed fixity of lower mantle structures, suggesting that the eastern margin of the African LLSVP margin has moved by as much as ~1450 km since late Permian times(260 Ma). The model of the plate-mantle system we present suggests that during the Permian Period, South China was proximal to the eastern margin of the African LLSVP and not the western margin of the Pacific LLSVP as previous thought. | Alexander Young Nicolas Flament Kayla Maloney Simon Williams Kara Matthews Sabin Zahirovic R.Dietmar Müller | 2019 | Geoscience Frontiers2019，10，3： | 10 |
| 2 | Smoking in schizophrenic patients:A critique of the selfmedication hypothesis显示文摘A common remark among laypeople, and notably also among mental health workers, is that individuals with mental illnesses use drugs as self-medication to allay clinical symptoms and the side effects of drug treatments. Roots of the self-medication concept in psychiatry date back at least to the 1980 s. Observations that rates of smokers in schizophrenic patients are multiple times the rates for regular smoking in the general population, as well as those with other disorders, proved particularly tempting for a self-medication explanation. Additional evidence came from experiments with animal models exposed to nicotine and the identification of neurobiological mechanisms suggesting self-medication with smoking is a plausible idea. More recently, results from studies comparing smoking and non-smoking schizophrenic patients have led to the questioning of the self-medication hypothesis. Closer examination of the literature points to the possibility that smoking is less beneficial on schizophrenic symptomology than generally assumed while clearly increasing the risk of cancer and other smoking-related diseases responsible for early mortality. It is a good time to examine the evidence for the self-medication concept as it relates to smoking. Our approach is to focus on data addressing direct or implied predictions of the hypothesis in schizophrenic smokers. | Francesca Manzella Susan E Maloney George T Taylor | 2015 | World Journal of Psychiatry2015，5，1： | 4 |
| 3 | Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits显示文摘分支链氨基酸 transaminases (BCAT ) 在分支链氨基酸白氨酸,异白氨酸,和缬氨酸的新陈代谢有一个关键角色。这些酶催化合成的最后步和这些氨基酸的降级的起始的步。尽管在植物的分叉的链氨基酸的 biosynthetic 小径广泛地被调查了,很多基因被描绘了,他们在植物的分解代谢完全还没被理解。我们以前在西红柿描绘了分叉的链氨基酸 transaminase 基因家庭,揭示 subcellular 本地化和六基因编码的酶的运动性质。这里,我们在水果开发期间检验了酶的可能的功能。我们进一步描绘了在分叉的链氨基酸 transaminases 的表示不同的转基因的植物 1 和 3,在线 overexpressing 任何一个 BCAT1 或 BCAT3 在在 BCAT1 和 volatiles 的层次缺乏的水果评估呼吸的率。我们测试的份量上经由喂实验的先锋和同位素,在水果 volatiles 的形成的分叉的链氨基酸和他们的相应 keto 酸的重要性。我们的结果不仅第一次在水果呼吸表明分叉的链氨基酸的重要性,而且揭示那 keto 酸,而非氨基酸,是为分叉的链风味 volatiles 的可能的先锋。 | Andrej Kochevenko Wagner L. Araujo Gregory S. Maloney Denise M. Tieman Phuc Thi Do Mark G. Taylor Harry J. Klee Alisdair R. Fernie | 2012 | Molecular Plant2012，5，2： | 4 |
| 4 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 5 | Rituximab resistance显示文摘 | Andrew R. Rezvani David G. Maloney | 2011 | Best Practice & Research Clinical Haematology2011，，2： | 3 |
| 6 | 想象与多元:十七世纪中国的茶壶外贸显示文摘小小的茶树(山茶属)却对欧洲人的健康、风俗和社会习惯产生了重大影响,若考虑到西方至十七世纪才开始接触茶叶,这种影响就更加非比寻常;欧洲首次正式从亚洲进口茶叶是在一六一○年。最初茶叶在广为接受之前主要用于医药领域。 | Shirley Maloney Mueller 王倩 | 2016 | 美成在久2016，，4： | 2 |
| 7 | Preoperative CA 19-9 and the Yield of Staging Laparoscopy in Patients with Radiographically Resectable Pancreatic Adenocarcinoma显示文摘 | Shishir K. Maithel MD Stephen Maloney MD Corrine Winston MD Mithat G?nen PhD Michael I. D'Angelica MD Ronald P. DeMatteo MD William R. Jarnagin MD Murray F. Brennan MD Peter J. Allen MD | 2008 | Annals of Surgical Oncology2008，，12： | 2 |
| 8 | Selective and Cell-Active Inhibitors of the USP1/ UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells显示文摘 | Junjun Chen Thomas S. Dexheimer Yongxing Ai Qin Liang Mark A. Villamil James Inglese David J. Maloney Ajit Jadhav Anton Simeonov Zhihao Zhuang | 2011 | Chemistry & Biology2011，，11： | 2 |
| 9 | In-depth analysis of molecular alterations within normal and tumour tissue from an entire bronchial tree 显示文摘 | Sikkink SK Liloglou T Maloney P | 2003 | Int J Oncol2003，22，3： | 1 |
| 10 | Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease 显示文摘 | Sethi S Maloney J Grove L | 2006 | Am J Respir Crit Care Med2006，173，9： | 1 |
| 11 | Anaerobic treatment of pinkwater in a fluidized bed reactor containing GAC 显示文摘 | Maloney S W Adrian N R Hickey R F | 2002 | J Hazard Mater2002，92，1： | 1 |
| 12 | The spouse:a factor in recovery after acute myocardial infarction显示文摘 | Beach E K Maloney B H Plocica A R | 1992 | Heart Lung1992，21，1： | 1 |
| 13 | A multicenter trial of photorefractive keratectomy for residual myopia after previous ocular surgery显示文摘 | Maloney RK chan WK Steinert R Hersh P O' Connell M | 1995 | Ophthalmology1995，102，7： | 1 |
| 14 | Accurate computation of the radiation from simple antennas using the finite- difference time- domain method显示文摘 | Maloney J G Smith G S Scott W R JR | 1990 | IEEE Trans Antennas and Propagat1990，38，7： | 1 |
| 15 | The administration of MS contin: clinical implication of use in end stage cancer显示文摘 | Maloney CM Kesner RK Klein G | 1989 | Am J Hospice Care1989，6，： | 1 |
| 16 | Differential c-Fos expression in cholinergic,mono-aminergic,and GABAergic cell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery显示文摘 | Maloney KJ Mainville L Jones BE | 1999 | J Neurosci1999，19，8： | 1 |
| 17 | The influence of continuous passive motion on outcome in total knee arthroplasty显示文摘 | Maloney WJ Schurman DJ Hangen D | 1990 | Clin Orthop1990，256，： | 1 |
| 18 | National joint replacement registries:has the time come显示文摘 | Maloney WJ | 2001 | J Bone Joint Surg(Am)2001，83，： | 1 |
| 19 | Artisan phakic intraocular lens for myopia:short-term results of a prospective,multicenter study显示文摘 | Maloney RK Nguyen LH John ME | 2002 | Ophthalmology2002，109，： | 1 |
| 20 | Anaerobic treatment of pinkwater in a fluidized bed reactor containing GAC显示文摘 | MALONEY S W ADRIAN N R HICKEY R F | 2002 | Journal of Hazardous Materials2002，92，： | 1 |
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