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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 3 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 4 | Enzymatic hydrolysis of casein: effect of degree of hydrolysis on antigenicity and physical properties 显示文摘 | MAHMOUD M MALONE W CORDLE C | 1992 | Joumai of Food Science1992，57，5： | 1 |
| 5 | Inhibition of TNF-αprotects against hepatic ischemia-reperfusion injury in rats via NF-κB dependent pathway显示文摘 | Mahmoud MF El Shazly SM Barakat W | 2012 | Naunyn Schmiedebergs Arch Pharmacol2012，385，5： | 1 |
| 6 | lnfluence of organic selenium on hsp 70 response of heat-stressed and enteropathogenic Escherichia coli-challenged broiler chickens (Gallus gallus) 显示文摘 | Kamel Z Mahmoud Edens F W | 2005 | Comparative Biochemistry and Physiology2005，141，： | 1 |
| 7 | On a Complex Duffing System with Random Excitation显示文摘 | XU Y XU W MAHMOUD G M | 2005 | Chaos Solitons and Fractal2005，23，： | 1 |
| 8 | Enzymatic hydrolysis of casein: Effect of degree of hydrolysis on antigenicity and physical properties 显示文摘 | Mahmoud M Malone W Cordle C | 1992 | Journal of Food Science1992，57，5： | 1 |
| 9 | A change point method for linear profile data 显示文摘 | Mahmoud M A Parker P A WoodaU W H Hawkins D M | 2007 | Quality and Reliability Engineering International2007，23，2： | 1 |
| 10 | Long-term treatment issues with chromite ore processing residue(COPR) : Cr6~ reduction and heave 显示文摘 | Deok H Mahmoud W Dimitris D | 2007 | Journal of Hazardous Materials2007，143，3： | 1 |
| 11 | Phase I analysis of linear profiles with calibration applications 显示文摘 | Mahmoud M A Woodall W H | 2004 | Technometrics2004，46，4： | 1 |
| 12 | Robust quantized approach to fuzzy networked control systems显示文摘 | Mahmoud M S Saif A W A | | 0，，1： | 1 |
| 13 | Enzymatic hydrolysis of casein, effect of degree of hydrolysis on antigenicity and physical properties显示文摘 | MAHMOUD M I MALONE W COROLLE C T | 1992 | J Food Sd1992，57，5： | 1 |
| 14 | Inf1uence of selenium sources on age-related and mid heat stress-related change of blood and liver glutathione redox cycle in broiler chickens显示文摘 | EDENS F W Mahmoud K Z | 2003 | Comp Biochem Physiol Bbiochem Mol Bio12003，136，4： | 1 |
| 15 | Faster fractal image compression using quadtree recomposition显示文摘 | Jackson D J Mahmoud W William A S | 1997 | Image and Vision Computing1997，15，10： | 1 |
| 16 | Faster fractal Image Compression Using Quadtree Recomposition 显示文摘 | JACKSON D J MAHMOUD W STAPLETON W A | 1997 | Image and Vision Computing1997，15，10： | 1 |
| 17 | Comparative evaluation of the efficacy of ginger and orlistat on obesity management, pancreatic lipase and liver peroxisomal catalase enzyme in male albino rats 显示文摘 | Mahmoud R H Elnout W A | 2013 | Eut Rcv IVied Pharmacoi Sci2013，17，1： | 1 |
| 18 | Enzymatic hydrolysis of casein:effect of degree of hydrolysis on antigenicity and physical properties显示文摘 | Mahmoud M L Malone W I Cordle C T | 1992 | J Food Science1992，57，5： | 1 |
| 19 | Analysis of reinforced concrete beams strengthened with FRP laminates显示文摘 | Mahmoud T Joseph W | 2000 | Journal of structural engineering2000，36，4： | 1 |
| 20 | Community onsite treatment of cold strong sewage in a UASB-septie tank 显示文摘 | Al-Jamal W Mahmoud N | 2009 | Bioresource technology2009，100，3： | 1 |
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