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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | The efficacy of muhiple-dose methotrexate treatment for unruptured tubal ectopic pregnancy and conversion rate to surgery:a study on 294 cases 显示文摘 | Balci O Ozdemir S Mahmoud AS | 2010 | Fertil Steril2010，93，7： | 1 |
| 3 | Detection of red ripe tomatoes on stem using image processing techniques 显示文摘 | HOSNA M M REZA A MAHMOUD O | 2011 | Journal of American Scionce2011，7，7： | 1 |
| 4 | Simu- lation, Integration, and Economic Analysis of Gas-to-Liquid Processes显示文摘 | Bao Buping El-Halwagi Mahmoud N Elbashir Nimir O | 2010 | Fuel Processing Technology2010，91，： | 1 |
| 5 | Design of fuzzy logic control system incorporating human expert knowledge for combine harvester显示文摘 | Mahmoud O Majid L Hossein M Reza A | 2010 | Expert Systems with Applications2010，，37： | 1 |
| 6 | Why do African A- mericans get more colon cancer them native Africans? 显示文摘 | O'keefe SJ Chung D Mahmoud N | 2007 | J Nutr2007，137，1： | 1 |
| 7 | Immunogenicity of recombinant hepatitis B vaccine in health care worker of Boo-All hospital in Tehran, iran, 2002-2004 显示文摘 | Taghavi O Eilami Mahmoud Nabavi | 2006 | Iranian Journal of Clinical Infectious Diseases2006，1，2： | 1 |
| 8 | Percutaneous nephrolithoto- my with ultrasonography guided renal access : experience from over 300 cases显示文摘 | Mahmoud O Gunnar WN Katrin H | 2005 | BJU Int2005，96，6： | 1 |
| 9 | Optic canal in-volvement in tuberculum sellae meningiomas:influenceon approach,recurrence,and visual recovery显示文摘 | Mahmoud M Nader R Al-Mefty O | 2010 | Neu-rosurgery2010，67，3： | 1 |
| 10 | Effect of coadministra- tion of dexamethasone with intrathecal morphine on postoper- ative outcomes after cesarean delivery显示文摘 | Mahmoud AA Ayman O Khaled M | 2012 | Int J Gynecol Ob- stet2012，116，2： | 1 |
| 11 | Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats显示文摘 | Ali BH Al-Wabel N Mahmoud O | 2005 | Fundam Clin Pharmacol2005，19，4： | 1 |
| 12 | J Incl Phenom Macrocycl Chem显示文摘 | Mahmoud M Al O Mohammad B Z Davies D J | 2007 | 57: 379-3842007，57，： | 1 |
| 13 | NonDestructive Ultrasonic Eevaluation of CFRP-Concrete Specimens Subjected to Accelerated Aging Conditions显示文摘 | Mahmoud A R Ammar H H Mukdadi O M | 2010 | NDT&E International2010，43，7： | 1 |
| 14 | The efficacy of multiple-dose Methotrexate treatment for unruptured tubal ectopic pregnancy and conversion rate to surgery:a study on 294 cases显示文摘 | Balci O Ozdemir S Mahmoud AS | 2010 | Fertil Steril2010，93，7： | 1 |
| 15 | Production of hot air with quasi uniform temperature using concentrated solar radiation显示文摘 | Mahmoud A O M Mead R B Belghitn A | 1998 | Renewable Energy1998，13，4： | 1 |
| 16 | Electro-dewatering of wastewater sludge:influence of the operating conditions and their interactions effects显示文摘 | MAHMOUD A JEREMY O JEAN V | 2011 | Water Research2011，45，9： | 1 |
| 17 | Plasma circulating cell-free nuclear and mitochondrial DNA as potential biomarkers in the peripheral blood of breast cancer patients显示文摘 | MAHMOUD E H FAWZY A AHMAD O K | 2015 | Asian Pac J Cancer Prev2015，16，18： | 1 |
| 18 | The effect of the aqueous extract of Cynomorium coccineum on the epididymal sperm pattern of the rat显示文摘 | Abd el-Rahman H A el-Badry A A Mahmoud O M | 1999 | Phytorher Res1999，13，3： | 1 |
| 19 | New CMOS fully - differential transconductor and application to a fully differential gm - c filter显示文摘 | SHAKER M O MAHMOUD S A SOLIMAN A M | 2006 | ETRL Journal2006，28，： | 1 |
| 20 | Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats显示文摘 | ALI B H AL-WABEL N MAHMOUD O | 2005 | Fundam Clin Pharmac2005，19，4： | 1 |
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