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| 1 | Biotransformation and degradation of 2,4,6-trinitrotoluene by microbial metabolism and their interaction显示文摘2,4,6-trinitrotoluene(TNT) and its derivatives are nitrogen-containing aromatic compounds having chemical and thermal stability at ambient temperature and pressure. TNT has high toxicity and mutagenic activity to humans, plants and animals, thus decontamination processes are necessary. Many microorganisms are capable to bioremediate TNT such as bacteria from the genera Pseudomonas,Enterobacter, Rhodococcus, Mycobacterium, Clostridium and Desulfovibrio: fungus such as Phanerochate and Stropharia species are able to perform TNT biotransformation under aerobic and anaerobic conditions. In this work we review the state of TNT biodegradation by various routes: aerobic, anaerobic,combined, fungal, enzymatic, and bio-electrochemical. | mónica y. serrano-gonzález rashmi chandra carlos castillo-zacarias felipe robledo-padilla magdalena de j. rostro-alanis roberto parra-saldivar | 2018 | Defence Technology(防务技术)2018，14，2： | 4 |
| 2 | Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites显示文摘AIM:To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.METHODS:A total of 88 consecutive severe cirrhotic patients seen in a large city hospital liver clinic were studied and divided into two groups,those with and without ascites.Group 1 consisted of 41 cirrhotic patients with massive ascites,as demonstrated by necessity for therapeutic large-volume paracentesis.Group 2consisted of 47 cirrhotic patients without any clinically documented ascites to include either a recent abdominal computed tomography scan or ultrasound study.Serum and ascitic fluid levels of an array of inflammatory markers,including procalcitonin,were measured and compared to each other and a normal plasma panel(NPP).RESULTS:The values for inflammatory markers assayed in the serum of Groups 1 and 2,and ascitic fluid of the Group 1.The plasma levels of the inflammatory cytokines interleukin(IL)-2,IL-4,IL-6,IL-8,interferon gamma(IFNγ)and epidermal growth factor(EGF)were all significantly greater in the serum of Group 1as compared to that of the serum obtained from the Group 2 subjects(all P<0.05).There were significantly greater serum levels of IL-6,IL-8,IL-10,monocyte chemoattractant protein-1,tumor necrosis factor-α,vascular endothelial growth factor and EGF when comparing Group 2 to the NPP.There was no significant difference for IL-1A,IL-1B,IL-2,IL-4 and IFNγlevels between these two groups.Serum procalcitonin levels were increased in cirrhotics with ascites compared to cirrhotics without ascites,but serum levels were similar to ascites levels within the ascites group.Furthermore,many of these cytokines,but not procalcitonin,demonstrate an ascites-to-serum gradient.Serum procalcitonin does not demonstrate any significant difference segregated by liver etiology in the ascites group;but ascitic fluid procalcitonin is elevated significantly in car-diac cirrhosis/miscellaneous subgroup compared to the hepatitis C virus and alcoholic cirrhosis subgroups.CONCLUSION:Procalcitonin in the ascitic fluid,but not in the serum,differentiates between cirrhotic subgroup reflecting the dynamic interplay of ascites,bacterial translocation and the peri-peritoneal cytokine. | Bashar M Attar Christopher M Moore Magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel | 2014 | World Journal of Gastroenterology2014，20，9： | 4 |
| 3 | Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics显示文摘AIM:To assess differing patterns and levels of ascitic fluid cyctokine and growth factors exist between those with a high risk and low risk of spontaneous bacterial peritonitis(SBP). METHODS: A total of 57 consecutive patients with ascites requiring a large volume paracentesis were studied. Their age, gender, specific underlying disease conditions were recorded after a review of their clinical records. Each underwent a routine assessment prior to their paracentesis consisting of a complete blood count, complete metabolic profile and prothrombin time/international normalized ratio(INR) determination. The ascitic fluid was cultured and a complete cellcount and albumin determination was obtained on the fluid. In addition, blood and ascitic fluid was assessed for the levels of interleukin interleukin(IL)-1A, IL-1B, IL-2, IL-4, IL-8, IL-10, monocyte chemotactic protein(MCP)-1, tumor necrosis factor(TNF)-α, interferon(IFN)-γ, vascular endothelial growth factor(VEGF) and epidermal growth factor(EGF) utilizing the Randox Biochip platforms(Boston, MA). A serum-ascites gradient, for each cytokine and growth factor was calculated. The results are reported as mean ± SEM between disease groups with statistical analysis consisting of the student t-test(two tailed) with a P value of 0.05 defining significance. RESULTS: No clinically important demographic or biochemical differences between the 4 groups studied were evident. In contrast, marked difference in the cytokine and growth factors levels and pattern were evident between the 4 disease groups. Individuals with alcoholic cirrhosis had the highest levels of IL-1A, IL-1B, IL-4, IFNγ. Those with malignant disease had the highest levels of IL-2. Those with hepatitis C virus(HCV) associated cirrhosis had the highest value for IL-6, IL-8, IL-10, MCP-1 and VEGF. Those with cardiac disease had the highest level of TNF-α and EGF. The calculated serum- ascites gradients for the cardiac and malignant disease groups had a greater frequency of negative values signifying greater levels of IL-8, IL-10 and MCP-1 in ascites than did those with alcohol or HCV disease. CONCLUSION: These data document important differences in the cytokine and growth factor levels in plasma, ascitic fluid and the calculated plasma- ascites fluid gradients in cirrhotics requiring a large volume paracentesis. These differences may be important in determining the risk for bacterial peritonitis. | Bashar M Attar Magdalena George Nicolae Ion-Nedelcu Guilliano Ramadori David H Van Thiel | 2014 | World Journal of Hepatology2014，6，2： | 3 |
| 4 | Signal transduction pathways in liver and the influence of hepatitis C virus infection on their activities显示文摘In liver,the most intensively studied transmembrane and intracellular signal transduction pathways are the Janus kinase signal transduction pathway,the mitogen-activated protein kinases signal transduction pathway,the transforming growth factor β signal transduction pathway,the tumor necrosis factor α signal transduction pathway and the recently discovered sphingolipid signal transduction pathway.All of them are activated by many different cytokines and growth factors.They regulate specific cell mechanisms such as hepatocytes proliferation,growth,differentiation,adhesion,apoptosis,and synthesis and degradation of the extracellular matrix.The replication cycle of hepatitis C virus(HCV) is intracellular and requires signal transduction to the nucleus to regulate transcription of its genes.Moreover,HCV itself,by its structural and non-structural proteins,could influence the activity of the second signal messengers.Thus,the inhibition of the transmembrane and intracellular signal transduction pathways could be a new therapeutic target in chronic hepatitis C treatment. | Magdalena M Dabrowska Anatol Panasiuk Robert Flisiak | 2009 | World Journal of Gastroenterology2009，15，18： | 3 |
| 5 | Removal of zinc( Ⅱ ) from spent hydrochloric acid solutions from zinc hot galvanizing plants 显示文摘 | Ryszard C Ireneusz M Magdalena R | 2002 | Industrial and Engineering Chemistry Research2002，41，3： | 1 |
| 6 | Escherichia coli 0157:H7 stress and virulence gene expression on Romaine lettuce using comparative real-time PCR 显示文摘 | Christine M Carey Magdalena Kostrzynska Stacey Thompson | 2009 | Journal of Microbiological Methods2009，77，： | 1 |
| 7 | Serum cystatin C as a marker of glomerular filtration rate 显示文摘 | Magdalena M Mark JS Lesley AS | 2006 | Curr Opin Nephrol Hypertents2006，15，6： | 1 |
| 8 | Development of complete hydrolysis of pectins from apple pomace显示文摘 | AGNIESZKA W MAGDALENA M ANNA S J | 2015 | Food Chemistry2015，172，： | 1 |
| 9 | Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors显示文摘 | Pawe S Magdalena M Elzbieta MO | 2011 | Bioorg Chem2011，56，39： | 1 |
| 10 | Phage display: Concept, innovations, applications and future 显示文摘 | JYOTI P MAGDALENA M SZENWCZYK | 2010 | Biotechnol Adv2010，28，： | 1 |
| 11 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in HIV-1 infected individuals显示文摘 | Magdalena M Theodorou L Debre P | 1999 | Blood1999，93，3： | 1 |
| 12 | Androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome 显示文摘 | Agnieszka H L Magdalena M Grzegorz P | 2009 | Endocr Relat Cancer2009，16，3： | 1 |
| 13 | The new methods of determination of Mg2+,Ca2+,Na+ and K+ ions in erythrocytes by ion selective electrodes显示文摘 | Adam M Magdalena M Z | 2005 | Sensors and Actuators B:Chemical2005，108，12： | 1 |
| 14 | Liquid chromatography- multiple tandem mass spectrometry for the determination of ten azaspiraeids, including hydroxyl analogues in shellfish 显示文摘 | Lehane M Shez M Magdalena A | 2004 | J Chromatogr A2004，1024，1： | 1 |
| 15 | Quarkonia measurements with ALICE at the LHC显示文摘 | MAGDALENA M | 2009 | Nucl Phys A2009，830，： | 1 |
| 16 | Interactions between APP secretases and inflammatory mediators 显示文摘 | MAGDALENA SASTRE JOCHEN WALTER STEVE M GENTLEMAN | 2008 | Neuroinflammation2008，5，： | 1 |
| 17 | Highly selective synthesis of 1 - (silyl) -1 -(boryl) ethenes via a ruthenium-catalyzed silylative coupling reaction 显示文摘 | Magdalena J Bogdan M Cezary P Joanna C | 2004 | Tetrahedron Lett2004，45，25： | 1 |
| 18 | High-Conversion-Efficiency Organic Dye-Sensitized Solar Cells:Molecular Engineering On D-A-1-A Featured Organic Indoline Dyes显示文摘 | Wu Y Z Magdalena Marszalek Zakeeruddin Shaik M | | 0，，08： | 1 |
| 19 | Inactivation of Bacillus stearothermophilus spores during thermal pro- cessing显示文摘 | JAN I AGNIESZKA P MAGDALENA M | 2006 | Journal of Food Engineering2006，77，： | 1 |
| 20 | A color visionbased lane tracking system for autonomous driving on unmarked roads显示文摘 | Angel S M Javier R F MagdAlenA Luis etc | 2004 | Autonomous Robots2004，16，1： | 1 |
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