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| 1 | Abiotic and Biotic Stresses and Changes in the Lignin Content and Composition in Plants显示文摘Lignin is a polymer of phenylpropanoid compounds formed through a complex biosynthesis route,represented by a metabolic grid for which most of the genes involved have been sequenced in several plants,mainly in the model-plants Arabidopsis thaliana and Populus.Plants are exposed to different stresses,which may change lignin content and composition.In many cases,particularly for plant-microbe interactions,this has been suggested as defence responses of plants to the stress.Thus,understanding how a stressor modulates expression of the genes related with lignin biosynthesis may allow us to develop study-models to increase our knowledge on the metabolic control of lignin deposition in the cell wall.This review focuses on recent literature reporting on the main types of abiotic and biotic stresses that alter the biosynthesis of lignin in plants. | Jullyana Cristina Magalhaes Silva Moura Cesar Augusto Valencise Bonine Juliana de Oliveira Fernandes Viana Marcelo Carnier Dornelas Paulo Mazzafera | 2010 | Journal of Integrative Plant Biology2010，52，4： | 45 |
| 2 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 3 | 针灸和药物针灸治疗肥胖的疗效回顾显示文摘Objective:The purpose of this study is to review the impact on the usage of traditional Chinese medicine in the treatment of obesity,specifically the usage of acupuncture and phytoacupuncture.Methods:PubMed and Google Scholar databases were searched to identify randomized controlled trials,which the methodology focused on the use of acupuncture and phytoacupuncture for the treatment of obesity from the beginning of these databases to February 2018,supplementing with literature retrospective and manual searches.Results:A total of 8 trials including 566 participants met the selected criteria.In the alterations of the body mass index and waist circumference,acupuncture and phytoacupuncture seems to have a positive effect as opposed to the subjects who received superficial acupuncture or none.However,there were other parameters that showed promising results such as improvements in the levels of(1)serum total cholesterol,low-density lipoprotein and serum fasting triglyceride,(2)serum insulin and leptin,plasma ghrelin and cholecystokinin and(3)serum pro-oxidant antioxidant balance,as well as improvements in(4)skin fat thickness in the upper limbs,trunk and abdomen,(5)abdominal fat and deep subcutaneous fat tissue.The main acupoints employed in the selected studies are found along several meridians such as the stomach,spleen and conception vessel,and the plants used had the main objective of accelerating the metabolism,reducing appetite and resolving the unbalances in the genesis of obesity.Conclusion:It is suggested that acupuncture and phytoacupuncture can be useful tools for weight loss.When combined with a life-style change,they can contribute to achieve better results than just a lifestyle change by itself.Nevertheless,the need for further studies to clarify mechanisms of action and adequacy of protocols in order to obtain more homogeneous results is also present. | Rosa Vilares Santos Jorge Magalhaes Rodrigues Maria Irene Jesus | 2020 | World Journal of Acupuncture-Moxibustion2020，30，3： | 5 |
| 4 | Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis显示文摘AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and gamma glutamyl transpeptidase(γGT) in patients with liver diseases. METHODS A systematic review with meta-analysis of ramdomized and controlled clinical trials was performed,evaluating the effects of sylimarin in patients with hepatic diseases,published by January 31,2016. Clinical trials were sought on the basis of The Cochrane Central Register of Controlled Trials in the Cochrane Library,Pub Med/Medline,Scopus,Web of Science,Lilacs and Clinical Trials. The trials with adult and elderly patients of both sexes,with Liver Diseases who took oral silymarin supplementation,as extract or isolated,as well as Silymarin combined with other nutrients,were included. The trials should provide information about the intervention,such as dosages and detailing of the product used,besides the mean and standard deviation of serum levels of ALT,AST and γGT of the baseline and at the end of the intervention.RESULTS An amount of 10904 publications were identified. From those,only 17 were included in the systematic review and 6 in the meta-analysis,according to the used selection criteria. In this meta-analysis,the results indicated a reduction of 0.26 IU/m L(95%CI:-0.46-0.07,P = 0.007) at the level of ALT and 0.53 IU/m L(95%CI:-0.74-0.32,P = 0.000) at the serum levels of AST after using the silymarin,both,statistically significant,but with no clinical relevance. There was no significant change in the γGT levels. Subgroup analyzes were also performed for the biochemical markers in relation to the type of intervention,whether silymarin isolated or associated with other nutrients and the time of intervention(whether ≥ 6 mo or < 6 mo). Significant differences were not found. The evaluated studies presented a high degree of heterogeneity and low methodological quality in the carried out analysis. CONCLUSION Silymarin minimally reduced,but without clinical relevance,the serum levels of ALT and AST. It is necessary to carry out studies with more appropriate methodological designs. | Camila Ribeiro de Avelar Emile Miranda Pereira Priscila Ribas de Farias Costa Rosangela Passos de Jesus Lucivalda Pereira Magalhaes de Oliveira | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 5 | Fiber Cavity Ring Down and Gain Amplification Effect显示文摘一个做耳的纤维放大器(EDFA ) 的效果把一枚洞戒指的纤维戒指放在内在下面(CRD ) 配置被学习。当水流的功能适用,到 EDFA 的获得也被介绍,这的限制和配置被讨论的优点,和铃流的学习预定。在这种情况中,在产量信号的力量变化强烈依赖于有 EDFA 获得的洞铃流时间。 | Susana SILVA Regina MAGALHAES Rosa Ana PEREZ-HERRERA Manuel LOPEZ-AMO M. B. MARQUES O. FRAZAO | 2016 | Photonic Sensors2016，6，4： | 4 |
| 6 | Calcium isotope fractionation and its controlling factors over authigenic carbonates in the cold seeps of the northern South China Sea显示文摘In this study, we analyzed stable calcium isotope results of authigenic carbonates from two cold seep areas of the Dongsha area and the Baiyun Sag in the northern South China Sea. The stable isotopes of carbon and oxygen as well as the mineral composition of authigenic carbonates were used to investigate control calcium isotope fractionation. The δ44/40Ca ratios of the southwestern Dongsha area samples ranged from 1.21‰ to 1.52‰ and the ratio of the Baiyun Sag sample was 1.55‰ of the SRM915a isotope standard. X-ray diffraction analysis showed that the carbonate samples consisted of dolomite, calcite and aragonite, with small amounts of high-Mg calcite and siderite. The δ13C values of the carbonates of the southwestern Dongsha area varied between δ49.21‰ and δ16.86‰ of the Vienna PeeDee Belemnite (VPDB) standard and the δ18O values ranged from 2.25‰ to 3.72‰ VPDB. The δ13C value of the Baiyun Sag sample was 2.36‰ VPDB and the δ18O value was 0.44‰ VPDB. The δ13C values of the carbonates of the southwestern Dongsha area revealed there is methane seeping into this area, with a variable contribution of methane-derived carbon. The sampled carbonates covered a range of δ13C values suggesting a dominant methane carbon source for the light samples and mixtures of δ13C values for the heavier samples, with possibly an organic or seawater carbon source. The δ18O values indicated that there is enrichment in 18O, which is related to the larger oxygen isotope fractionation in dolomite compared to calcite. The results of the Baiyun Sag sample exhibited normal seawater carbon and oxygen isotopic values, indicating that this sample is not related to methane seepage but instead to precipitation from seawater. The relatively high δ44/40Ca values indicated either precipitation at comparatively high rates in pore-water regimes with high alkalinity, or precipitation from an evolved heavy fluid with high degrees of Ca consumption (Raleigh type fractionation). The dolomite samples from the Dongsha area revealed a clear correlation between the carbon and calcium isotope composition, indicating a link between the amount and/or rate of carbonate precipitation and methane contribution to the bicarbonate source. The results of the three stable isotope systems, mineralogy and petrography, show that mineral composition, the geochemical environment of authigenic carbonates and carbon source can control the calcium isotope fractionation. | WANG ShuHong YAN Wen MAGALHAES H Vitor CHEN Zhong PINHEIRO M Luis GUSSONE Nikolaus | 2012 | Chinese Science Bulletin2012，57，11： | 4 |
| 7 | Congenital heart diseases trends in S?o Paulo State,Brazil:a national live birth data bank analysis显示文摘Background Congenital heart diseases(CHD)are the most common type of birth defects,affecting millions of newborns every year;no prevalence data are available in S?o Paulo State,Brazil's most populous state.The objective is to identify trends in prevalence and risk factors for CHD in Sao Paulo State,Brazil.Methods We developed a population-based study to estimate the CHD trend of prevalence in recent years,stratified by maternal age and geographical clusters,using all cases of CHD identified by the Live Births Information System(SINASC-Sistema de Informa??o Sobre Nascidos Vivos)from January 1,2005,to December 31,2018.We calculated the trends of prevalence,the regression coefficient(β),the annual percent change(APC),and 95%confidence interval using the Prais-Winsten regression model,with the Durbin-Watson test.Results We found 10,594 cases of CHD among 8,536,101 live births(LB),a prevalence of 12.4/10,000 LB.There was no difference in the sex distribution;they are primarily Caucasian(60.2%),75.2%born at term,and 74.4%weight>2500 g,66.9%of births were by cesarean section.S?o Paulo State presented an increasing CHD trend of prevalence(APC=18.9%).The highest CHD prevalence rate was in mothers aged≥35 years(22.2/10,000 LB).There were 12,271 specific congenital heart defects among 10,594 patients(1.16 CHD/patient).Atrial septal defect has the highest number of cases(3835),with a prevalence of 4.49/10,000 LB,corresponding to 31.3%of all CHD.Conclusion CHD had an increasing prevalence trend in recent years,being highest in S?o Paulo City and≥35-year mothers. | Paola Soares Fernandes Larissa Rosario Magalhaes Tainara Rita Pezzini Edige Felipe de Sousa Santos Mauricio Giusti Calderon | 2022 | World Journal of Pediatrics2022，18，7： | 3 |
| 8 | Scanning electron microscope study of biofilm formation at different flow rates over metal surfaces using sulphate-reducing bacteria显示文摘 | Claudia M. L. M. Coutinho Fatima C. M. Magalhaes Tania C. Araujo-Jorge | 1993 | Biofouling1993，，1： | 2 |
| 9 | Giant squamous cell carcinoma of the gallbladder: A case report显示文摘BACKGROUND Gallbladder cancer is the most common malignant tumor of the biliary tract. The majority of cases are adenocarcinoma. Squamous cell carcinoma is the histological type present in 12% of all neoplasias accounting for approximately 12% of gallbladder neoplasms. It can occur in its pure form reaching 1%-3% of the tumors. Many patients are at an advanced stage when diagnosed and have bad therapeutic efficacy. CASE SUMMARY A 45-year-old male patient presented with left flank pain for 1 year and irradiated to the mesogastric region. He denied fever, vomiting, and any other intestinal changes. He reported a weight loss of 10 kg in a period of 7 mo. He denied alcoholism, smoking, drug use, or prior illness. Computed tomography of the abdomen showed in the gallbladder fossa a voluminous mesogastric heterogeneous collection that had a thick and irregular capsule with liquid and gaseous contents. A predominantly hypoattenuating rounded material with partially calcified margins measuring about 2.0 cm related to gallstone was also emphasized. No lymphadenomegalies or free fluid was observed in the abdominal cavity. Patient underwent laparotomy where a huge tumor was observed affecting the transverse colon and gallbladder. This mass was resected en bloc removing gallbladder and transverse colon together with corresponding mesocolon and regional lymphadenectomy. There were no complications in the postoperative period. Although oncological treatment was performed, the patient died 6 mo after surgery. CONCLUSION Squamous cell carcinoma represents a rare disease. Patients often present with large, bulky tumors with involvement of adjacent organs. In spite of progress in surgical techniques and adjuvant chemotherapy, the prognosis remains poor. | Marcelo AF Ribeiro Junior Murillo de Lima Favaro Stephanie Santin Cintia Magalhaes Silva Ana Paula Marconi Iamarino | 2019 | World Journal of Clinical Cases2019，7，18： | 2 |
| 10 | Cloning and expression of functional shikimate dehydrogenase from Mycobacterium tuberculosis H37Rv显示文摘 | Magalhaes M L B Pereira C P Basso L A | 2002 | Protein Expression and Purification2002，26，： | 2 |
| 11 | Guidelines for Collection of Biological Samples for Clinical and Forensic Toxicological Analysis显示文摘This article aims to review general procedures for sampling of routinely collected as well as on alternative samples that may provide additional information regarding intoxication.These approaches may be applied whenever sample collection for clinical and forensic toxicology is required and should be considered as general guidelines that must be adapted to each specific case.It is expected that this article will help toxicologists and other forensic experts to accomplish their mission,since the toxicological result is first influenced by the quality and quantity of the sample available for analysis.These guidelines were approved by the European Council of Legal Medicine. | Ricardo Jorge Dinis-Oliveira Duarte Nuno Vieira Teresa Magalhaes | 2016 | Forensic Sciences Research2016，1，1： | 2 |
| 12 | Al−Mg−Si合金在低温下的流变行为和断裂显示文摘研究AA6061合金的拉伸和断裂行为,为该合金在低温范围内的拉伸和断裂行为提供定量数据。在298 K、173 K和77 K下对铝合金进行固溶处理,然后在应变速率为0.1~0.0001 s^(−1)条件下进行拉伸试验。结果表明,77 K时Portevin−Le Chatelier(PLC)效应和动态应变时效(DSA)被抑制。相反,298 K时,观察到PLC效应的特征,即明显的锯齿状流变。77 K固溶处理后样品的拉伸性能与173 K和298 K处理的样品拉伸性能相比,强度、伸长率、韧性模量、应变硬化指数和应变速率敏感性同时提高,这与低温下动态回复速率的降低有关。与之相对应,断口形貌结果显示,77 K处理的样品韧窝尺寸减小,而韧窝覆盖的面积增加。173 K和77 K处理的样品中DSA被抑制,其实验结果与Johnson−Cook模型模拟结果吻合较好。 | Danielle Cristina Camilo MAGALHAES Andrea Madeira KLIAUGA Vitor Luiz SORDI | 2021 | Transactions of Nonferrous Metals Society of China2021，31，3： | 2 |
| 13 | Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China显示文摘Background:Leptospirosis morbidity and mortality rates in China have decreased since the 2000s.Further analyses of the spatiotemporal and demographic changes occurring in the last decade and its implication on estimates of disease burden are required to inform intervention strategies.In this study,we quantified the epidemiological shift and geographical heterogeneity in the burden of leptospirosis during 2005-2015 in China.Methods:We used reported leptospirosis case data from 1st January 2005 to 31st of December 2015 that routinely collected by the China Information System for Disease Control and Prevention(CISDCP)to analyze the epidemiological trend and estimate the burden in terms of disability-adjusted life-years(DALYs)over space,time,and demographical groups.Results:A total of 7763 cases were reported during 2005-2015.Of which,2403(31%)cases were the laboratoryconfirmed case.Since 2005,the notified incidence rate was gradually decreased(P<0.05)and it was relatively stable during 2011-2015(P>0.05).During 2005-2015,we estimated a total of 10313 DALYs were lost due to leptospirosis comprising a total of 1804 years-lived with disability(YLDs)and 8509 years-life lost(YLLs).Males had the highest burden of disease(7149 DALYs)compared to females(3164 DALYs).The highest burden estimate was attributed to younger individuals aged 10-19 years who lived in southern provinces of China.During 2005-2015,this age group contributed to approximately 3078 DALYs corresponding to 30%of the total DALYs lost in China.Yet,our analysis indicated a declining trend in burden estimates(P<0.001)since 2005 and remained relatively low during 2011-2015.Low burden estimates have been identified in the endemic regions where infections principally distributed.Most of the changes in DALY estimates were driven by changes in YLLs.Conclusions:In the last 11-years,the burden estimates of leptospirosis have shown a declining trend across the country;however,leptospirosis should not be neglected as it remains an important zoonotic disease and potentially affecting the young and productive population in economically less-developed provinces in southern of China.In addition,while in the last five years the incidence has been reported at very low-level,this might not reflect the true incidence of leptospirosis.Strengthened surveillance in the endemic regions is,hence,substantially required to capture the actual prevalence to better control leptospirosis in China. | Pandji Wibawa Dhewantara Abdullah AMamun Wen-Yi Zhang Wen-Wu Yin Fan Ding Danhuai Guo Wenbiao Hu Federico Costa Albert Icksang Ko Ricardo JSoares Magalhaes | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 14 | 从拜耳法母液中回收镓显示文摘引言 1871年,D·I·门捷列夫预言了镓的存在,他根据其周期系把它称为类铝。1875年,P·E·Lecog de Boisbaudran用光谱方法在闪锌矿中发现一种新的元素。后来,他把它分离,并研究其特征;它们与预言为类铝的物质完全相同。在化学上,镓呈酸性在pH=4和pH=9之间形成氢氧化物。从30~1900℃,金属镓呈液态。当伴生有砷或磷之类的元素时,它成为一种半导体。它的半导体性能比硅好,由于这个原因,被广泛地看作优良的微电子元件。 | Afonsode Magalhaes 许孙曲 | 1993 | 轻金属1993，，5： | 2 |
| 15 | Qigong in the treatment of children with autism spectrum disorder:A systematic review显示文摘Background: Autism spectrum disorder is a condition that affects all races, ethnic and socioeconomic groups. With a high incidenee ratio of one in every 68, it has become one of the most discussed psychiatric disorders. For this reason, the need for investigating novel treatments has been emerging. Qigong, a traditional Chinese mind-body technique, has already proven to be able to reduce symptoms of several physical and psychological illnesses. Objective: The purpose of this systematic review is to examine and categorize the current scientific evidence regarding the efficacy of Qigong on children suffering from autism spectrum disorders. Search strategy: A systematic literature search of the electronic scientific databases PubMed, Clinical Trials.gov, BioMed Central, PubMed Central and Google Scholar was performed to identify studies of Qigong in the treatment of children with autism spectrum disorder. Inclusion criteria: This review included randomized controlled trials, replication studies, retrospective studies and observational follow-up studies of Qigong on children with autism spectrum disorder. Case reports and case series were excluded. Data extraction and analysis: Two researchers independently evaluated the methodological quality of all included studies. Any discrepancies were solved by discussion until consensus was achieved. Results: Our literature search identified 157 publications, and 10 additional publications from hand search of references. After duplicate removal, 103 records remained. After the title/abstract screening, 19 publications were obtained for detailed evaluation. After detailed evaluation, 10 studies were included. Seven studies were conducted with small children with 2-6 years old employing Qigong massage, and three studies were con ducted with older children aged 7-17 years old applying both Qigong massage (one study) and Neigong (two studies). Conclusion: Studies demonstrated that Qigong has interesting and promising applicability and effect on children with autism spectrum disorder and should be tested further. Despite the need for more rigorous controlled studies, Qigong seems to be able to decrease severity of individual sensory, behavioural, and language components of autism, and improve self-control, sociability, sensory and cognitive awareness as well as healthy-physical behaviour. Besides positive effect on children and adolescents, benefits seem to extend to parents and caregivers as well. However, quality of methodology seems to be insufficient to state that Qigong is an alternative to common behavioural therapies. We suggest that, until more investigation is performed, Qigong may only be used as a complement, or when behavioural therapies are not accessible. | Jorge Magalhaes Rodrigues Mariana Mestre Larry Ibarra Fredes | 2019 | Journal of Integrative Medicine2019，17，4： | 2 |
| 16 | Activity of enzymes involved in the nitrogen metabolism in different maize genotypes 显示文摘 | Machado A T Magalhaes J R Magnavaca R | 1992 | Revista Gbrasileira de Fisiologia Vegetal1992，4，1： | 1 |
| 17 | Hyalinzing trabecular tumor of the thyroid displaying neuroendocrine differentiation显示文摘 | Magalhaes J Sobrinho-Simoes M | 2004 | Virchows Arch2004，445，1： | 1 |
| 18 | Study of physiological parameters for the selection of maize genotypes efficient in ammonium uptake 显示文摘 | MAGALHAES J R PURCINO A A C MACHADO A T | 1990 | Documentos EmpresaCapixaba de Pesquisa Agropecuaria1990，65，： | 1 |
| 19 | Molybdate conversion coatings on zinc surfaces 显示文摘 | Magalhaes A A O Margarit I C P | 2004 | Journal of Electroanalytical Chemistry2004，572，2： | 1 |
| 20 | Macro- phage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation 显示文摘 | Magalhaes ES Mourao-Sa DS Vieira-de-Abreu A | 2007 | Eur J Immunol2007，37，4： | 1 |
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