共被期刊论文引用了2次
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| 1 | 胆汁在法医毒物学中的应用研究进展显示文摘胆汁排泄是毒物及其代谢物的重要消除途径,胆汁因同时具有亲水和亲脂的双重性质而成为毒物及其结合型代谢物分布的主要器官。其因具有毒物浓度高、存在代谢物、检测时限长、受再分布影响小等特性而成为死后毒物学领域关注的生物检材。通过对近20年文献报道的回顾,综述了胆汁中毒物定性、定量分析的研究成果,提供了数百个案例中胆汁和血液毒药物定量结果信息,讨论了胆汁毒物分析的特点、价值及其问题,提出当摄毒延缓死亡或毒物半衰期短时,以及血液检材不可获得或可靠性存疑时,胆汁可作为毒药物筛查的备选检材或为血液等其他检材的定量分析提供补充及验证。 | 纪佼佼 严慧 沈敏 | 2018 | 中国司法鉴定2018，，5： | 0 |
| 2 | Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault显示文摘In recent years,benzodiazepines and benzodiazepine-like drugs are the most common substances associated with drug-facilitated sexual assaults(DFSA);however,barbiturates are also detected occasionally.Segmental hair analysis provides useful information on the historic pattern of drug use,enabling differentiation between single exposure in DFSA cases and chronic use.However,sensitive and specific methods for barbiturate analysis in hair samples are needed.Herein,we present an ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry(UHPLC-HRMS)method for qualitative and quantitative determination of seven barbiturates in hair samples.Firstly,a hair strand was decontaminated and then freeze-milled in liquid nitrogen.Next,50mg of powdered hair was extracted with methanol in an ultrasonic bath for 10 min in the presence of 10 ng phenobarbital-d5.The supernatant was dried under nitrogen gas,and the pellet was dissolved in 100 μL mobile phase.Afterwards,10 μL of the suspension was injected into the UHPLC-HRMS system.The present method involved two UHPLC conditions for determination of barbiturates(I)and identification of the structural isomers amobarbital and pentobarbital(II).This method showed satisfactory linearity in a range of 0.02–20.00 ng/mg for UHPLC conditions I and II,both with a high determination coefficient(0.9991–0.9999).The selectivity,intra-and interday precision,accuracy and matrix effect of the method were acceptable.Next,the validated method was applied to investigate an authentic DFSA case.Hair samples(black,approximate 25cm long)were collected 3 months after the assault,and the proximal segments(0–5 cm from the root;each segment was 1 cm long)were analysed.Amobarbital was detected at a concentration of | Di Wen Yan Shi Xiaoguang Zhang Bing Xie Wenqiao Liu Feng Yu Ping Xiang Bin Cong Chunling Ma | 2022 | Forensic Sciences Research2022，7，1： | 0 |
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