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| 1 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 4 | Trauma-induced alterations in macrophage function显示文摘 | Mc Carler M D Mack V E Daly T M | 1998 | Surgery1998，123，： | 2 |
| 5 | Moleeular mechanisms of Staphylococcus epidermidis biofilm formation显示文摘 | Mack D | 1999 | J Hosp Infect1999，43，： | 1 |
| 6 | The stress of organisational change:A dynamic process model显示文摘 | Nelson D L Quick J C | 1998 | Applied Psychology:An International Review1998，，2： | 1 |
| 7 | Hypoxia, HIFs, and cardiovascular development显示文摘 | Simon M C Ramircz-Bergeron D Mack F | 2003 | Cold Spring Harb Symp Quant Biol2003，67，： | 1 |
| 8 | Wedge resection versus iobectomy for stage I (T1N0M0) non-small cell lung cancer显示文摘 | Landreneau R J Sugarbaker D J Mack M J | 1997 | J Thorac Cardiovasc Surg1997，113，4： | 1 |
| 9 | Development and independent laboratory validation of a simple method for the determination of paraquat and diquat in potato, cereals and pulses显示文摘 | Kolberg D I Mack D Anastassiades M | 2012 | Anal Bioanal Chem2012，404，8： | 1 |
| 10 | The non-structural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle显示文摘 | DE DIEGO M BROCCHI E MACK AY D | 1997 | Arch Virol1997，142，10： | 1 |
| 11 | Amniotic membrane transplantation for acute chemical or thermal burns显示文摘 | Meller D Pires RTF Mack RJS | 2000 | Ophthalmology2000，107，： | 1 |
| 12 | Amniotic membr-ane transplantation for acute chemical or thermal burns显示文摘 | Meller D Pires RT Mack RJ | 2000 | Ophthalmology2000，107，： | 1 |
| 13 | Amniotic membrane transplantation for acute chemical or thermal burns 显示文摘 | Meller D pires RT Mack R J | 2000 | Ophthalmology2000，107，5： | 1 |
| 14 | 3_ parallel tabu search al- gorithm for solving the container loading problem显示文摘 | BORTFELDT A GEHRING H MACK D | 2003 | Parallel Com- puting2003，29，5： | 1 |
| 15 | Evasion of p53 and G2/M checkpoints are characteristic of Hh-driven basal cell careinoma 显示文摘 | Li Z J Mack S C Mak T H Angers S Taylor M D Hui C C | 2014 | Oncogene2014，33，： | 1 |
| 16 | Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial显示文摘 | Helen M Colhoun D John Betteridge Paul N Durrington Graham A Hitman H Andrew W Neil Shona J Livingstone Margaret J Thomason Michael I Mackness Valentine Charlton-Menys John H Fuller | 2004 | The Lancet . 2004 (9435)2004，，9435： | 1 |
| 17 | New generation perovskite thermal barrier coating materials 显示文摘 | Ma W Jarligo M O Mack D E | 2008 | Journal of Thermal Spray Technology2008，17，56： | 1 |
| 18 | Capacitive deioniza- tion of NaCI and NaNOa solutions with carbon aerogel elec- trodes显示文摘 | Farmer J C Fix D V Mack G V | 1996 | J Electrochem Soc1996，143，1： | 1 |
| 19 | Effect of prior o- ophorectomy on changes in bone mineral density and carotid artery intima- media thickness in postmenopausaI women显示文摘 | Mucowski SJ Mack WJ Shoupe D | 2014 | Fertil Steril2014，101，4： | 1 |
| 20 | Nuclear signalling by tumour-assoeiated antigen EpCAM 显示文摘 | Maetzel D Denzel S Mack B | 2009 | Nat Cell Biol2009，11，2： | 1 |
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