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	题名	作者	年代	出处	被引量
1	Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer.	Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu	2007	World Journal of Gastroenterology2007，13，34：	15
2	The effect of posture on the role of the apophysial joints in resisting intervertebral compressive forces显示文摘	Adams MA Hutton WC	1980	J Bone Joint Surg(Br)1980，62，3：	1
3	Arteriovenous fistulas for hemodialysis access in children and adolescents using the proximal radial artery inflow site 显示文摘	Jennings WC Turman MA Taubman KE	2009	Journal of Pediatric Surgery2009，44，7：	1
4	The role of conservative treatment in idiopathic granulomatous mastitis 显示文摘	Lai EC Chan WC Ma TK	2005	Breast J2005，11，：	1
5	Outc-omes from out-of-hospital cardiac arrest in metropolitan taipei:does an advanced life support service make a difference显示文摘	Ma MH Ching WC Ko PC	2007	J Resuscitation2007，74，2：	1
6	Disc space narrowing and the lumbar facet joints显示文摘	Dunlop RB Adams MA Hutton WC	1984	J Bone Joint Surg Br1984，66，5：	1
7	Cyclic strain upregulates nitric ox- ide synthase in cultured bovine aortic endothelial cells显示文摘	Awolesi MA Sessa WC Sumpio BE	1995	J Clin In- vest1995，96，3：	1
8	Adhesion of a self-etching system to dental substrate prepared byEr:YAG laser or air abrasion 显示文摘	Souza-Zaroni WC Chinelatti MA Delfino CS	2008	J Biomed Mater Res B Appl Biomater2008，86，2：	1
9	Respiration during sleep in the aged human显示文摘	Catskadon MA Dement WC	1981	J Gerontol1981，36，4：	1
10	Transplanted human fetal neural stem cells survive,migrate,anddifferentiate in ischemic rat cerebral cortex显示文摘	Kelly S Bliss TM Shah AK Sun GH Ma M Foo WC	2004	Proc Natl AcadSci U S A2004，101，11：	1
11	Global experience curves for wind farms显示文摘	JUNGINGER MA FAAIJ WC TURKENBURG	2005	EnergyPolicy2005，，33：	1
12	Investigation of a Campylobacter jejuni outbreak by serotyping and chromosomal restriction endonuclease analysis 显示文摘	Bradbury WC Pearson AD Marko MA	1984	J Clin Microbiol1984，19，3：	1
13	DNA polymerase gamma in mitochondrial DNA replication and repair 显示文摘	Graziewicz MA Longley M J Copeland WC	2006	Chem Rev2006，106，2：	1
14	Vascular closure devices in patients treated with anticoagulation and Ⅱb/Ⅲa receptor inhibi-tors during pereutaneous revascularization显示文摘	Applegate RJ Grabarczyk MA Little WC	2002	J Am Coll Cardiol2002，40，：	1
15	Effect of inflamma torycytokines of hypoxia-induced erythropoietin production显示文摘	Faquin WC Schemeider TJ Goldberg MA	1992	Blood1992，79，19：	1
16	The stage of disc degenration as revealed by discograms 显示文摘	Adams MA Dolan P Hutton WC	1986	J Bone Joint Surg Br1986，68，：	1
17	The novel receptor TRAIL-R4 induced NF-kappaB and pro tects against TRAIL mediated apoptosis, yct retains an incomplete death domain显示文摘	Degli-Esposti MA Dougall WC Smolak PJ		0，，：	1
18	Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the funetiona differentiation of dendritic cell progenitors显示文摘	Antonysamy MA Fanslow WC Fu F	1999	J Im- munol1999，162，1：	1
19	Evidence for a role of IL-17 in organ allograft rejection:IL-17 promotes the functional differentiation of dendritic cell progenitors显示文摘	Antonysamy MA Fanslow WC Fu F		0，，15：	1
20	Low-density lipoprotein subclass patterns and risk of myocardial infarction显示文摘	Breslow JL Hennekens CH Buring JE Willett WC Krauss RM	1988	JAMA1988，260，13：	1

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